Conserved transcriptional activity and ligand responsiveness of avian PPARs: Potential role in regulating lipid metabolism in mirgratory birds

Hamilton, Angelica; Ly, Jennifer; Robinson, Jasmine R.; Corder, Keely R.; DeMoranville, Kristen J.; Schaeffer, Paul J.; Huss, Janice M.

doi:10.1016/j.ygcen.2018.08.009

Cited by 11 publications

(3 citation statements)

References 54 publications

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“…Generally, these studies found that dietary PUFAs have little to no influence on lipid oxidative capacity and that seasonal changes and/or exercise may have larger impacts on muscle physiology ( Carter et al, 2021 ; Dick and Guglielmo, 2019 ; Price et al, 2022 ). Although EPA and DHA are potent ligands for PPAR, other fatty acids found in our diets can also be ligands, such as 18:3 n-3 and 18:2 n-6 ( Hamilton et al, 2018 ; Mochizuki et al, 2006 ). Furthermore, increasing the availability of potent ligands does not necessarily increase the abundance of PPAR mRNA ( Dick and Guglielmo, 2019 ; Nagahuedi et al, 2009 ), but can do so in isolated shorebird muscle in vitro ( Young et al, 2021 ).…”

Section: Discussionmentioning

confidence: 99%

Experimental evidence that EPA and DHA are dietary requirements in a migratory shorebird, but they do not affect muscle oxidative capacity

Dick,

Hobson,

Guglielmo

2024

Journal of Experimental Biology

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Dietary n-3 long chain polyunsaturated fatty acids (LCPUFA) are hypothesized to be natural doping agents in migratory shorebirds, enabling prolonged flight by increasing membrane fluidity and oxidative capacity of the flight muscles. Animals can obtain n-3 LCPUFA from the diet or by conversion of dietary α-linolenic acid, 18:3 n-3. However, capacity to meet n-3 LCPUFA requirements from 18:3 n-3 varies among species. Direct tests of muscle oxidative enhancement and fatty acid conversion capacity are lacking in marine shorebirds that evolved eating diets rich in n-3 LCPUFA. We tested whether the presence and type of dietary fatty acids influence the fatty acid composition and flight muscle oxidative capacity in western sandpipers (Calidris mauri). Sandpipers were fed diets low in n-3 PUFA, high in 18:3 n-3, or high in n-3 LCPUFA. Dietary fatty acid composition was reflected in multiple tissues, and low intake of n-3 LCPUFA decreased abundance of these fatty acids in all tissues, even with a high intake of 18:3 n-3. This suggests that 18:3 n-3 cannot replace n-3 LCPUFA, and dietary n-3 LCPUFA are required for sandpipers. Flight muscle indicators of enzymatic oxidative capacity and regulators of lipid metabolism did not change. However, the n-3 LCPUFA diet was associated with increased FAT/CD36 mRNA expression, potentially benefitting fatty acid transport during flight. Our study suggests that flight muscle lipid oxidation is not strongly influenced by n-3 PUFA intake. The type of dietary n-3 PUFA strongly influences the abundance of n-3 LCPUFA in the body and could still impact whole-animal performance.

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Section: Discussionmentioning

confidence: 99%

Experimental evidence that EPA and DHA are dietary requirements in a migratory shorebird, but they do not affect muscle oxidative capacity

Dick,

Hobson,

Guglielmo

2024

Journal of Experimental Biology

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“…These results also suggest that consuming fruits with low fat content but sufficient antioxidants, such as Winterberry (Ilex verticillata; , while on stopover may still allow birds to increase non-enzymatic antioxidant capacity, but in different ways. However, further research is needed on the absorption (Beaulieu and Schaefer, 2013;, possible microbial contribution (Laparra and Sanz, 2010;Saag et al, 2011), and the integration of dietary antioxidants into other physiological systems (Aboonabi and Singh, 2015;Hamilton et al, 2018;DeMoranville, 2020) in migratory birds for an adequate understanding of how dietary antioxidants improve antioxidant capacity.…”

Section: Non-enzymatic Antioxidant Capacitymentioning

confidence: 99%

“…What remains to be determined is how variation in fruit species and availability across stopover sites may alter these decisions, how decisions at one stopover location may carryover to decisions at the next (Legagneux et al, 2012;McKinnon et al, 2015;. Also unknown is (1) exactly how absorption of dietary antioxidants and fats from fruits are affected by the physiological state of the organism (e.g., gut microbiome; Trevelline et al, 2019) or by other macro-andmicronutrients in the fruits and (2) how antioxidants consumed at a stopover site are integrated into other physiological systems (e.g., peroxisome proliferator-activated receptors, glucocorticoid production Hamilton et al, 2018;Casagrande et al, 2020). The results from our experiment can help inform future studies that examine whether the behavioral responses of these four species at one stopover site do in fact influence the overall pace and survival of birds during migration.…”

Section: Hypothesis 2: Oxidative Damage Decreases With Rest and Refue...mentioning

confidence: 99%

Fat Stores and Antioxidant Capacity Affect Stopover Decisions in Three of Four Species of Migratory Passerines With Different Migration Strategies: An Experimental Approach

Cooper-Mullin

McWilliams

2022

Front. Ecol. Evol.

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During migratory stopovers, birds must make decisions about when and where to travel and these decisions are likely contingent on their fuel stores, food availability, and antioxidant capacity as well as seasonal changes in key environmental factors. We conducted a field experiment on an offshore stopover site (Block Island, Rhode Island, United States: 41°130N, 71°330W) during autumn migration to test the hypothesis that birds with greater fuel stores and non-enzymatic antioxidant capacity have shorter stopovers than lean birds with low antioxidant capacity, and to determine the extent to which this depends on migration strategy. We used a 2 × 2 factorial field experiment (two levels each of available food and dietary polyphenols) with four species of songbirds kept in captivity for 3–5 days to produce experimental groups with different fuel stores and antioxidant capacity. We attached digital VHF transmitters to assess stopover duration and departure direction using automated telemetry. Non-enzymatic antioxidant capacity increased during refueling for Red-eyed Vireos (Vireo olivaceus) and Blackpoll Warblers (Setophaga striata) fed ad lib diets, and for ad lib fed Hermit Thrushes (Catharus guttatus) supplemented with polyphenols, but not for Yellow-rumped Warblers (Setophaga coronata coronata). Glutathione peroxidase (GPx) decreased during captivity and was influenced by dietary treatment only in Red-eyed Vireos. Oxidative damage decreased during captivity for all species except Yellow-rumped Warblers. Stopover duration was shorter for Vireos and Blackpolls fed ad lib as compared to those fed maintenance. Ad lib fed Hermit Thrushes supplemented with polyphenols had shorter stopovers than those fed ad lib, as did thrushes fed at maintenance and supplemented with polyphenols compared with those fed at maintenance alone. There was no influence of condition on stopover duration for Yellow-rumped Warblers. Departure direction was not strongly related to condition, and birds primarily reoriented north when departing Block Island. Thus, fat stores and oxidative status interacted to influence the time passerines spent on stopover, and condition-dependent departure decisions were related to a bird’s migration strategy. Therefore, seasonal variation in macro- and micro-nutrient resources available for refueling at stopover sites can affect body condition and antioxidant capacity and in turn influence the timing and success of migration.

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Age Dynamics of the Biochemical Blood Indices in Smena-9 Broilers

Koshcheeva

2021

Fundamental and Applied Scientific Research in the Development of Agriculture in the Far East (AFE-2021)

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Conserved transcriptional activity and ligand responsiveness of avian PPARs: Potential role in regulating lipid metabolism in mirgratory birds

Cited by 11 publications

References 54 publications

Experimental evidence that EPA and DHA are dietary requirements in a migratory shorebird, but they do not affect muscle oxidative capacity

Experimental evidence that EPA and DHA are dietary requirements in a migratory shorebird, but they do not affect muscle oxidative capacity

Fat Stores and Antioxidant Capacity Affect Stopover Decisions in Three of Four Species of Migratory Passerines With Different Migration Strategies: An Experimental Approach

Age Dynamics of the Biochemical Blood Indices in Smena-9 Broilers

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