Conserved subcortical processing in visuo-vestibular gaze control

Wibble, Tobias; Pansell, Tony; Grillner, Sten; Pérez‐Fernández, Juan

doi:10.1038/s41467-022-32379-w

Cited by 30 publications

(36 citation statements)

References 65 publications

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“…Instead, we find that vestibular projection neurons synapse on to extraocular motor neurons (Figure 6) well before those motor neurons synapse on to muscles 114 . Comparative approaches [115][116][117] could resolve the question of whether the temporal differences we observe are zebrafish-specific. Together, our work rejects the current model for vestibulo-ocular reflex ontogeny.…”

Section: Circuit Assembly: First-come First Served or Firstborn First...mentioning

confidence: 99%

Neuronal birthdate reveals topography in a vestibular brainstem circuit for gaze stabilization

Goldblatt

Huang

Greaney

et al. 2022

Preprint

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Across the nervous system, neurons with similar attributes are topographically organized. This topography reflects developmental pressures. Oddly, vestibular (balance) nuclei are thought to be disorganized. By measuring activity in birthdated neurons, we revealed a functional map within the central vestibular projection nucleus that stabilizes gaze in the larval zebrafish. We first discovered that both somatic position and stimulus selectivity follow projection neuron birthdate. Next, with electron microscopy and loss-of-function assays, we found that patterns of peripheral innervation to projection neurons were similarly organized by birthdate. Lastly, birthdate revealed spatial patterns of axonal arborization and synapse formation to projection neuron outputs. Collectively, we find that development reveals previously hidden organization to the input, processing, and output layers of a highly-conserved vertebrate sensorimotor circuit. The spatial and temporal attributes we uncover constrain the developmental mechanisms that may specify the fate, function, and organization of vestibulo-ocular reflex neurons. More broadly, our data suggest that, like invertebrates, temporal mechanisms may assemble vertebrate sensorimotor architecture.

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Section: Circuit Assembly: First-come First Served or Firstborn First...mentioning

confidence: 99%

Neuronal birthdate reveals topography in a vestibular brainstem circuit for gaze stabilization

Goldblatt

Huang

Greaney

et al. 2022

Preprint

View full text Add to dashboard Cite

show abstract

“… 83 , 113 Instead, we find that vestibular projection neurons synapse on to extraocular motor neurons ( Figure 6 ) well before those motor neurons synapse on to muscles. 114 Comparative approaches 115 – 117 could resolve the question of whether the temporal differences we observe are zebrafish specific. Together, our work rejects the current model for vestibulo-ocular reflex ontogeny.…”

Section: Discussionmentioning

confidence: 99%

Neuronal birthdate reveals topography in a vestibular brainstem circuit for gaze stabilization

Goldblatt¹,

Huang²,

Greaney³

et al. 2023

Current Biology

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“…Another visually-driven behavior often compared to insect optomotor response is optokinetic nystagmus (OKN) (Hardcastle and Krapp, 2016). OKN is a syn-directional eye movement triggered by optic flow, which is found across vertebrates from jawless fish (Wibble et al, 2022) to humans (Dodge, 1903;Dodge and Fox, 1928), as well as in arthropods (Fenk et al, 2022) and cephalopods (Messenger, 1970). Similar to rotational vection, it has been found that vertical stationary patterns can strongly suppress OKN in humans (Murasugi et al, 1989(Murasugi et al, , 1986.…”

Section: Geometrical Negative Evidence Against Self Rotation In Diffe...mentioning

confidence: 99%

Neural mechanisms to incorporate visual counterevidence in self motion estimation

Tanaka

Zhou

Agrochão

et al. 2023

Preprint

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SummaryIn selecting a behavior, animals should weigh sensory evidence both for and against their beliefs about the world. For instance, animals use optic flow to estimate and control their own rotation. However, existing models of flow detection can confuse the movement of external objects with genuine self motion. Here, we show that stationary patterns on the retina, which constitute negative evidence against self rotation, are used by the fruit flyDrosophilato suppress inappropriate stabilizing rotational behavior. In parallelin silicoexperiments, we show that artificial neural networks trained to distinguish self and world motion incorporate similar negative evidence. We used neural measurements and genetic manipulations to identify components of the circuitry for stationary pattern detection, which is parallel to the fly’s motion- and optic flow-detectors. Our results exemplify how the compact brain of the fly incorporates negative evidence to improve heading stability, exploiting geometrical constraints of the visual world.

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Conserved subcortical processing in visuo-vestibular gaze control

Cited by 30 publications

References 65 publications

Neuronal birthdate reveals topography in a vestibular brainstem circuit for gaze stabilization

Neuronal birthdate reveals topography in a vestibular brainstem circuit for gaze stabilization

Neuronal birthdate reveals topography in a vestibular brainstem circuit for gaze stabilization

Neural mechanisms to incorporate visual counterevidence in self motion estimation

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