Conserved signaling pathways genetically associated with longevity across the species

Khan, Abdul Haseeb; Zou, Zhiwen; Yang, Xiaowen; Chen, Shenghan; Tian, Xiao-Li

doi:10.1016/j.bbadis.2018.09.001

Cited by 30 publications

(15 citation statements)

References 147 publications

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“…The cellular energy sensor AMPK is activated under a high AMP-to-ATP ratio (i.e., low energy availability) and also in response to the upstream tumor suppressor Lkb1. AMPK has many downstream targets, including TSC2, which is activated by AMPK to inhibit TOR signaling (Lin and Hardie 2018;Khan et al 2019). Not surprisingly, these highly conserved pathways mediate diverse responses of GSC lineages to dietary inputs (Laws and Drummond-Barbosa 2017).…”

Section: Diet and Diet-dependent Signalingmentioning

confidence: 99%

Local and Physiological Control of Germline Stem Cell Lineages in Drosophila melanogaster

Drummond‐Barbosa

2019

Genetics

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The long-term survival of any multicellular species depends on the success of its germline in producing high-quality gametes and maximizing survival of the offspring. Studies in Drosophila melanogaster have led our growing understanding of how germline stem cell (GSC) lineages maintain their function and adjust their behavior according to varying environmental and/or physiological conditions. This review compares and contrasts the local regulation of GSCs by their specialized microenvironments, or niches; discusses how diet and diet-dependent factors, mating, and microorganisms modulate GSCs and their developing progeny; and briefly describes the tie between physiology and development during the larval phase of the germline cycle. Finally, it concludes with broad comparisons with other organisms and some future directions for further investigation.

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Section: Diet and Diet-dependent Signalingmentioning

confidence: 99%

Local and Physiological Control of Germline Stem Cell Lineages in Drosophila melanogaster

Drummond‐Barbosa

2019

Genetics

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“…Identification of further longevity genes will depend on understanding their GxE interactions, as proposed by Hook et al (2018), and also discussed for Alzheimer's disease (Finch and Kulminski 2019). Many longevity genes are shared broadly across short-and long-lived animals (Longo and Finch 2003;Hook et al 2018;Khan et al 2019). Curiously, chimpanzee genomes have not been considered for genes that might contribute to the human-evolved postreproductive phase of life span that is unique among hominids (Table 4).…”

Section: Longevity Genes and Gxementioning

confidence: 99%

The Exposome in Human Evolution: From Dust to Diesel

Trumble¹,

Finch²

2019

The Quarterly Review of Biology

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Global exposures to air pollution and cigarette smoke are novel in human evolutionary history and are associated with about 16 million premature deaths per year. We investigate the history of the human exposome for relationships between novel environmental toxins and genetic changes during human evolution in six phases. Phase I: With increased walking on savannas, early human ancestors inhaled crustal dust, fecal aerosols, and spores; carrion scavenging introduced new infectious pathogens. Phase II: Domestic fire exposed early Homo to novel toxins from smoke and cooking. Phases III and IV: Neolithic to preindustrial Homo sapiens incurred infectious pathogens from domestic animals and dense communities with limited sanitation. Phase V: Industrialization introduced novel toxins from fossil fuels, industrial chemicals, and tobacco at the same time infectious pathogens were diminishing. Thereby, pathogen-driven causes of mortality were replaced by chronic diseases driven by sterile inflammogens, exogenous and endogenous. Phase VI: Considers future health during global warming with increased air pollution and infections. We hypothesize that adaptation to some ancient toxins persists in genetic variations associated with inflammation and longevity.

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“…To date there has been much speculation as to how and why we age and die based on descriptive biology. All such attempts are founded on the gene-centric view of biology (58), driven by the Darwinian view that evolution is due to random mutation and Natural Selection. However, that perspective is becoming more and more questionable (59), yet there has been nothing to supplant it in order to fulfill Dobzhansky's "Nothing in biology makes sense except in the light of evolution" (60), behooving us to solve the riddle, or suffer the consequences for all eternity (with apologies for the hyperbole).…”

Section: Discussionmentioning

confidence: 99%

Cell-cell communication predicts aging, senescence and death: an integrated, predictive evolutionary approach

Torday

2019

Biomedical Reviews

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None of the extant theories of aging have proven to be effective in advancing our knowledge of senescence or mortality. In contrast to the gene-centric focus on evolution, the mechanism of cell-cell interactions as the driving force for evolution as the logic of biology is proposed. Since the distribution of bioenergy over the course of the life cycle is skewed towards the reproductive phase, bioenergy flags in the post-reproductive stage of life, causing failure of cell-cell signaling, loss of homeostatic control, senescence and death. In the interim, the phenotype acts as the 'agent' for epigenetic inheritance, obtaining 'marks' that inform the organism of changes in the environment. Such marks are inherited by the offspring, providing it with foreknowledge of the environment to come. The organism appears to 'return' to the unicellular state over the course of the life cycle, but in reality meiosis is the mechanism of epigenetic inheritance, the adult phenotype being the means for transmitting the epigenetic marks obtained from the environment back to the organism.

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Conserved signaling pathways genetically associated with longevity across the species

Cited by 30 publications

References 147 publications

Local and Physiological Control of Germline Stem Cell Lineages in Drosophila melanogaster

Local and Physiological Control of Germline Stem Cell Lineages in Drosophila melanogaster

The Exposome in Human Evolution: From Dust to Diesel

Cell-cell communication predicts aging, senescence and death: an integrated, predictive evolutionary approach

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