1994
DOI: 10.1002/eji.1830240912
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Conserved distribution of λ subtypes from rearranged gene segments to immunoglobulin synthesis in the mouse B cell repertoire

Abstract: The immunoglobulin lambda light chain system displays a limited diversity in inbred mice. Indeed, the lambda locus is organized in two recombination units: V lambda 2-V lambda x-J lambda 2-C lambda 2-psi J lambda 4-psi C lambda 4, which can produce either lambda 2(V2) or lambda 2(Vx) chains; and V lambda 1-J lambda 3-C lambda 3-J lambda 1-C lambda 1, which can produce either lambda 1 or lambda 3 chains. Each of these units is associated with an enhancer, E lambda 2-4 or E lambda 1-3, at the 3' side. The expres… Show more

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Cited by 14 publications
(9 citation statements)
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“…These data are in agreement with other reports and our previous observations in normal mice (reviewed in [5,6,81). …”
Section: H Cellular Distribution Among Spleen B Cellssupporting
confidence: 94%
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“…These data are in agreement with other reports and our previous observations in normal mice (reviewed in [5,6,81). …”
Section: H Cellular Distribution Among Spleen B Cellssupporting
confidence: 94%
“…As we observed 12 V2J2 productive joints for 5 V1J3 (see Fig. 1) we can estimate that there are 18 YO of h2(V2) cells and 8 Yo of h3 cells since these joints are co-amplified with the same efficiency [6]. Furthermore, we show that the profiles of productive junctions are globally conserved among the bone marrow pre-B cells and the mature spleen.…”
Section: A Speculative View About the Establishment Of The Emergent Hsupporting
confidence: 68%
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“…Because these “open” ESCs could potentially undergo re-integration, rather than cut-and-run, we were keen to assess the level of unligated signal ends in vivo . To this end, we examined the Igλ locus where 60%–70% of recombination occurs between Vλ1 and JCλ1 (Boudinot et al., 1994), and thus the Vλ1Jλ1 ESC is generated in the majority of Igλ-positive cells. Using LM-PCR, we find that unligated Vλ1Jλ1 signal ends are detectable, but only weakly (Figure 5C).…”
Section: Resultsmentioning
confidence: 99%
“…In H3-and M54-Tg mice, we can consider that the potential diversity of B cell receptor is limited to four combinations, i.e. p-transgeneencoded chain with one type of h subtype (the h junctional diversity is extremely restricted [32]). In the hypothesis of a negative selection, three out of four combinations should display autoreactivity against unknown self-antigens in both p-transgenic mice.…”
Section: Positive Versus Negative Selectionmentioning
confidence: 99%