Conserved distal promoter of the agouti signaling protein (ASIP) gene controls sexual dichromatism in chickens

Oribe, Eri; Fukao, Ayaka; Yoshihara, Chihiro; Mendori, Misa; Rosal, Karen G.; Takahashi, Sumio; Tanaka, Sakae

doi:10.1016/j.ygcen.2012.04.016

Cited by 29 publications

(19 citation statements)

References 33 publications

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“…In vertebrates, the principal MCR gene expressed in the skin and implicated in melanogenesis is the melanocortin 1 receptor gene ( MC1R , (Mundy, 2005; Ducrest et al., 2008). Control over expression is achieved via the agonist α ‐melanocortin‐stimulating hormone (α ‐MSH ) and two inverse agonists agouti signaling protein ( AsIP ) and agouti‐related neuropeptide ( AgRP ) (Ducrest et al., 2008; Oribe et al., 2012). High expression of AsIP and AgRP and binding of these inverse agonists induces the production of yellow‐reddish pheomelanic pigments, whereas if the agonist binds to the MC1R , then more black eumelanic pigments are produced (Ducrest et al., 2008).…”

Section: Introductionmentioning

confidence: 99%

Age‐ and quality‐dependent DNA methylation correlate with melanin‐based coloration in a wild bird

Soulsbury

Lipponen

Wood

et al. 2018

Ecology and Evolution

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Secondary sexual trait expression can be influenced by fixed individual factors (such as genetic quality) as well as by dynamic factors (such as age and environmentally induced gene expression) that may be associated with variation in condition or quality. In particular, melanin‐based traits are known to relate to condition and there is a well‐characterized genetic pathway underpinning their expression. However, the mechanisms linking variable trait expression to genetic quality remain unclear. One plausible mechanism is that genetic quality could influence trait expression via differential methylation and differential gene expression. We therefore conducted a pilot study examining DNA methylation at a candidate gene (agouti‐related neuropeptide: AgRP) in the black grouse Lyrurus tetrix. We specifically tested whether CpG methylation covaries with age and multilocus heterozygosity (a proxy of genetic quality) and from there whether the expression of a melanin‐based ornament (ultraviolet‐blue chroma) correlates with DNA methylation. Consistent with expectations, we found clear evidence for age‐ and heterozygosity‐specific patterns of DNA methylation, with two CpG sites showing the greatest DNA methylation in highly heterozygous males at their peak age of reproduction. Furthermore, DNA methylation at three CpG sites was significantly positively correlated with ultraviolet‐blue chroma. Ours is the first study to our knowledge to document age‐ and quality‐dependent variation in DNA methylation and to show that dynamic sexual trait expression across the lifespan of an organism is associated with patterns of DNA methylation. Although we cannot demonstrate causality, our work provides empirical support for a mechanism that could potentially link key individual factors to variation in sexual trait expression in a wild vertebrate.

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Section: Introductionmentioning

confidence: 99%

Age‐ and quality‐dependent DNA methylation correlate with melanin‐based coloration in a wild bird

Soulsbury

Lipponen

Wood

et al. 2018

Ecology and Evolution

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“…An absence of mature melanocytes underlies the unpigmented white bars in the feathers of some chicken breeds [2] and it may be that the black at hatch locus ( Bh ) is involved in longitudinal stripe formation on the dorsum of quail [3]. However, these mechanisms cannot explain patterning involving phaeomelanin-eumelanin differences which are thought to rely on differential regulation of MC1R activity [2,4–6]. …”

Section: Introductionmentioning

confidence: 99%

“…The dorso-ventral and temporal-specific regulation of ASIP expression occurs via different promoters in mice [16,17,20]. In adult chicken and quail, ASIP may function in dorso-ventral patterning, within-feather patterning and sexual dichromatism [4,6,21]. Birds also have multiple alternatively spliced transcripts of ASIP , with some evidence to suggest that the distal promoter site is also ventral specific [4,21] but overall their relationship to pattern function in birds is poorly understood compared to mammals.…”

Section: Introductionmentioning

confidence: 99%

“…Previous studies on the function of ASIP and POMC in bird plumage patterns were conducted in adults and did not control well for developmental stage, potentially resulting in an under-estimation of the contribution of these ligands [4–6,21]. In this study, we examined the relative contribution of melanocyte differentiation, MC1R inhibition and MC1R stimulation to the species-typical plumage.…”

Section: Introductionmentioning

confidence: 99%

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The differential expression of MC1R regulators in dorsal and ventral quail plumages during embryogenesis: Implications for plumage pattern formation

Gluckman

Mundy

2017

PLoS ONE

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Melanin pigmentation patterns are ubiquitous in animals and function in crypsis, physical protection, thermoregulation and signalling. In vertebrates, pigmentation patterns formed over large body regions as well as within appendages (hair/feathers) may be due to the differential distribution of pigment producing cells (melanocytes) and/or regulation of the melanin synthesis pathway. We took advantage of the pigmentation patterns of Japanese quail embryos (pale ventrum and patterned feathers dorsally) to explore the role of genes and their transcripts in regulating the function of the melanocortin-1-receptor (MC1R) via 1. activation: pro-opiomelanocortin (POMC), endoproteases prohormone convertase 1 (PC1) and 2 (PC2), and 2. inhibition—agouti signaling and agouti-related protein (ASIP and AGRP, respectively). Melanocytes are present in all feather follicles at both 8 and 12 days post-fertilisation (E8/E12), so differential deposition of melanocytes is not responsible for pigmentation patterns in embryonic quail. POMC transcripts expressed were a subset of those found in chicken and POMC expression within feather follicles was strong. PC1 was not expressed in feather follicles. PC2 was strongly expressed in all feather follicles at E12. ASIP transcript expression was variable and we report four novel ASIP transcripts. ASIP is strongly expressed in ventral feather follicles, but not dorsally. AGRP expression within feather follicles was weak. These results demonstrate that the pale-bellied quail phenotype probably involves inhibition of MC1R, as found previously. However, quail may require MC1R activation for eumelanogenesis in dorsal feathers which may have important implications for an understanding of colour pattern formation in vertebrates.

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“…Plumage color is an important economic trait, which plays a crucial role in determining breed purity and phylogenesis. The coloration of hairs in mammals is mainly determined by the distribution of two types of melanin, eumelanin and pheomelanin, which produce brown to black and yellow to red colorations, respectively (Oribe et al, 2012). Of note, TYR and TYRP1 are involved in regulation and control of melanin synthesis.…”

Section: Introductionmentioning

confidence: 99%

Association of Tyrosinase (TYR) and Tyrosinase-related Protein 1 (TYRP1) with Melanic Plumage Color in Korean Quails (<italic>Coturnix coturnix</italic>)

Zhang

Pang

2013

Asian Australas. J. Anim. Sci

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TYR (Tyrosinase) and TYRP1 (Tyrosinase-related protein 1) play crucial roles in determining the coat color of birds. In this paper, we aimed to characterize the relationship of TYR and TYRP1 genes with plumage colors in Korean quails. The SNPs were searched by cDNA sequencing and PCR-SSCP in three plumage color Korean quails (maroon, white and black plumage). Two SNPs (367T→C and 1153C→T) were found in the coding region of TYRP1 gene, but had no significant association with plumage phenotype in Korean quails. The expression of TYR was higher in black plumage quails than that in maroon plumage quails. In contrast, the expression of TYRP1 was lower in black plumage quails than that in maroon plumage quails. This study suggested that the melanic plumage color in Korean quails may be associated with either increased production of TYR or decreased production of TYRP1.

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Conserved distal promoter of the agouti signaling protein (ASIP) gene controls sexual dichromatism in chickens

Cited by 29 publications

References 33 publications

Age‐ and quality‐dependent DNA methylation correlate with melanin‐based coloration in a wild bird

Age‐ and quality‐dependent DNA methylation correlate with melanin‐based coloration in a wild bird

The differential expression of MC1R regulators in dorsal and ventral quail plumages during embryogenesis: Implications for plumage pattern formation

Association of Tyrosinase (TYR) and Tyrosinase-related Protein 1 (TYRP1) with Melanic Plumage Color in Korean Quails (<italic>Coturnix coturnix</italic>)

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Conserved distal promoter of the agouti signaling protein (ASIP) gene controls sexual dichromatism in chickens

Cited by 29 publications

References 33 publications

Age‐ and quality‐dependent DNA methylation correlate with melanin‐based coloration in a wild bird

Age‐ and quality‐dependent DNA methylation correlate with melanin‐based coloration in a wild bird

The differential expression of MC1R regulators in dorsal and ventral quail plumages during embryogenesis: Implications for plumage pattern formation

Association of Tyrosinase (TYR) and Tyrosinase-related Protein 1 (TYRP1) with Melanic Plumage Color in Korean Quails (&lt;italic&gt;Coturnix coturnix&lt;/italic&gt;)

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Association of Tyrosinase (TYR) and Tyrosinase-related Protein 1 (TYRP1) with Melanic Plumage Color in Korean Quails (<italic>Coturnix coturnix</italic>)