Conservative treatment with ketoacid and amino acid supplemented low-protein diets in chronic renal failure

Abstract

Twenty-six patients with advanced renal failure (glomerular filtration rate less than 6 ml/min) were treated with a mixed quality low protein diet and ketoacid analogues. An improvement in nitrogen balance, serum transferrin and phosphate, and base excess was observed after 2 weeks of treatment. In a longer term study, the result of 20 patients treated with ketoacids for up to 14 months were compared to a group 40 patients who received a low-protein diet with essential amino acids. Patients responded similarly to the two diets; however, the group receiving ketoacids had a significantly lower glomerular filtration rate. There was improvement in calcium and phosphate metabolism with ketoacid treatment. The patients were able to tolerate treatment with both the ketoacids and vitamin D.

Suppression of Parathyroid Hormone by Therapy with a Mixture of Keto Analogues/Amino Acids in Hemodialysis Patients

“…These findings seem to be supported by the fact that a number of uremic symptoms may be improved by para thyroidectomy [1, 4,5]. Our previous studies showed a decline of elevated PTH levels in patients treated with a low-protein diet and substitution of a mixture of essential amino acids or their a-keto analogues (K A) [7,8], respec tively. These observations were in agreement with the results of Barsotti et al [3].…”

Randomized controlled clinical trial of ketoanalogues supplementation in dogs with chronic kidney disease

“…Besides the cost-effectiveness issue, to the authors' knowledge, until this date, no other study in literature was designed to investigate the effect of ketoanalogues in dogs with chronic kidney disease. Although one case report described the effectiveness of ketoanalogues when associated with a low protein diet (Veado et al 2002), all the literature is focused in humans (Frohling et al 1980, Jones et al 1983, Mitch et al 1984, Tóth et al 2012, Teplan et al 2000, Prakash et al 2004, Thilly 2013.…”

Influence of Aminosteril on Serum Parathyroid Hormone Levels in Hemodialysis Patients

“…Attempts to control these abnormalities include dietary phosphorus restriction, prescription of calcium carbonate to reduce phosphate absorption from the gut, and treatment with calcitriol [2]. In addition, previous studies showed a decline of elevated PTH levels in patients treated with a low-protein diet and substitution of mixture of essential amino acids or their ·-keto analogues (KA) [3,4], respectively. These observations were in agreement with the results of chronic hemodialysis patients who received a high-protein diet during a 3 months' administration of KA [5].…”