Advancements in minimally invasive surgery have allowed uterine myomectomy to be performed laparoscopically with several well-established advantages. However, contention exists regarding the practicality of the laparoscopic approach for large uterine leiomyomas. As a result, many gynaecologists still prefer open surgery. Notwithstanding, several measures exist to combat the technical challenges of the procedure. These include manipulating port placement, the use of a laparoscopic tourniquet, and alternatives to laparoscopic power morcellation. Herein, we report a successful laparoscopic myomectomy performed in a nulliparous 33-year-old woman with a large symptomatic subserosal leiomyoma. In addition, we outline the steps and modifications to a standard laparoscopic myomectomy to facilitate the removal of a large uterine leiomyoma.