Conservative therapy of breast cancer in Queensland

Burke, M Barbara; Allison, R.; Tripcony, Lee

doi:10.1016/0360-3016(94)e0210-b

Cited by 52 publications

(24 citation statements)

References 23 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Young age, along with EIC, was previously reported as a predictor of finding residual carcinoma at the time of reexcision in this patient population [10]. Even in patients with no residual tumor at re-excision, however, EIC was a significant predictor of local recurrence in the current series, in contrast to several series that have shown that EIC does not appear to be prognostic independent of margin status [18][19][20][21]. This may be a spurious observation, considering the small number of patients in this series with documented EIC and negative re-excision findings.…”

Section: Discussioncontrasting

confidence: 55%

The Role of a Boost Radiation Dose in Patients with Negative Re-Excision Findings

Horst¹

2011

TOBCANJ

View full text Add to dashboard Cite

Abstract:The aim of this study is to evaluate whether patients who have no residual tumor at the time of a re-excision lumpectomy benefit from the addition of a radiation boost dose. The records of 535 patients treated with breastconserving therapy (BCT) for Stage I-II breast cancer were reviewed. The actuarial risk of local recurrence (LR) was determined for the 262 patients in this cohort who underwent re-excision lumpectomy. There was no significant difference in the 10-year freedom from local recurrence (FFLR) for patients with negative re-excisions (96%) compared to patients with residual tumor that was adequately excised (92%). Patients with residual tumor at or close to the final margins, however, had a significantly lower FFLR (80%; p=.01). The FFLR for patients with negative re-excisions was 97% for patients not receiving a boost (n=94) and 95% for patients who received a boost (n=74) (p=ns). For patients <50, FFLR was 96% with a boost and 87% without a boost (p=ns). Extensive intraductal component was the only significant predictor of LR among patients with negative re-excisions (p=.02). The presence of residual disease in the re-excision specimen did not predict for LR as long as the final margins were negative. Among patients with negative re-excisions, the boost did not significantly improve local control. There was a trend for better outcomes, however, in younger patients treated with a boost even in the setting of a negative re-excision. Due to the limitations of the retrospective nature of this study, it will be important to address this question in a prospective fashion before making any definitive conclusions or changes in current clinical practice.

show abstract

Section: Discussioncontrasting

confidence: 55%

The Role of a Boost Radiation Dose in Patients with Negative Re-Excision Findings

Horst¹

2011

TOBCANJ

View full text Add to dashboard Cite

show abstract

“…There were a few studies (Braun et al 2005;Kanemori and Prygrocki 2005;Lee et al 1997) about the breast conservative treatment on eastern women, but not suYcient, especially in China. The size of Chinese female breasts is always smaller, and the age at diagnosis of the patients in China is always younger than that in western countries (Burke et al 1995;Nattinger et al 1996;Chuba and Simon 1997). Some surgeons doubted that the BCT was appropriate for Chinese women whose clinical characteristics are diVerent from that of western women.…”

Section: Discussionmentioning

confidence: 99%

“…Because of the ethnic diVerences, the size of the Chinese female breasts is always smaller than that of the western females and the age of the breast cancer patients in China is always younger than western women and a considerable proportion of 60% breast cancer patients in China are premenopausal (Burke et al 1995;Jacobson et al 1995;Nattinger et al 1996;Lam et al 2005;Braun et al 2005;Huang et al 2001). The biological behavior of the breast cancer in eastern might be rather diVerent than that in western.…”

Section: Introductionmentioning

confidence: 99%

Breast conservative therapy in east part of China: a retrospective cohort study

Jiang

Wang

et al. 2006

J Cancer Res Clin Oncol

View full text Add to dashboard Cite

show abstract

“…22-4), and insistence on good, histologically negative margins eliminated the observed increase in recurrence of cancer within the treated breast. [173][174][175][176][177] As a result, surgeons and radiation oncologists no longer dissuade young patients from breast conservation but pay careful attention to the histology and uniformly recommend re-excision of the biopsy site. 161 The re-excision is done to establish optimal margins and to be sure all EIC, if present, has been excised.…”

Section: How Does Age Affect the Decision-making Process?mentioning

confidence: 99%

Multimodality Treatment of Breast Cancer

Niederhuber¹

2005

Breast Cancer

View full text Add to dashboard Cite

Conservative therapy of breast cancer in Queensland

Cited by 52 publications

References 23 publications

The Role of a Boost Radiation Dose in Patients with Negative Re-Excision Findings

The Role of a Boost Radiation Dose in Patients with Negative Re-Excision Findings

Breast conservative therapy in east part of China: a retrospective cohort study

Multimodality Treatment of Breast Cancer

Contact Info

Product

Resources

About