Conservative Surgical Treatment of Medulloepithelioma of the Ciliary Body

Cassoux, Nathalie; Charlotte, Frédéric; Sastre, Xavier; Orbach, Daniel; LeHoang, Phuc; Desjardins, Laurence

doi:10.1001/archophthalmol.2009.404

Cited by 19 publications

(17 citation statements)

References 6 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Treatment of malignant medulloepithelioma with surgical excision and brachytherapy, or brachytherapy alone, has been explored. 26, 31 The effectiveness of radiation therapy and chemotherapy for high-risk tumors with spread beyond the eye is unknown.…”

Section: Classificationmentioning

confidence: 99%

Intraocular Medulloepithelioma

Saunders¹,

Margo²

2012

Archives of Pathology &Amp; Laboratory Medicine

View full text Add to dashboard Cite

Intraocular medulloepithelioma is a congenital tumor of the ciliary epithelium that typically presents during the first decade of life. The histologic diagnosis is based on characteristic ribbons of pseudostratified neuroepithelium admixed with loose mesenchymal tissue rich in hyaluronic acid, vaguely resembling developing retina and vitreous. More than a third of medulloepitheliomas contain heteroplastic tissue, which in some cases makes up most of the tumor. Malignant medulloepitheliomas consist of a proliferation of neuroblasts, which in areas can be indistinguishable from retinoblastoma. Unlike its highly malignant counterpart in the central nervous system, intraocular medulloepithelioma has a good prognosis as long as tumor has not spread beyond the eye. Definitive diagnosis and eye-conserving therapy is possible with fine-needle aspiration biopsy. The histologic differential diagnosis of medulloepithelioma is broad, ranging from retinoblastoma and sarcoma to ciliary epithelial adenoma and adenocarcinoma.

show abstract

Section: Classificationmentioning

confidence: 99%

Intraocular Medulloepithelioma

Saunders¹,

Margo²

2012

Archives of Pathology &Amp; Laboratory Medicine

View full text Add to dashboard Cite

show abstract

“…15 In large series of 41 patients including children and adults, conservative treatment by brachytherapy was performed in only in 3 cases (9%) with an apex dose of 40 ECG. 15 In large series of 41 patients including children and adults, conservative treatment by brachytherapy was performed in only in 3 cases (9%) with an apex dose of 40 ECG.…”

Section: Discussionmentioning

confidence: 99%

“…Conservative surgical treatment gives a good result for small tumors and can be followed by a brachytherapy to control potential remaining tumor cells. 15 In large series of 41 patients including children and adults, conservative treatment by brachytherapy was performed in only in 3 cases (9%) with an apex dose of 40 ECG. 2 In a recent series using a Ruthenium-106 Plaque in children, ME was well controlled and 80% of patients notes a tumor regression at 26 months' follow-up.…”

Section: Discussionmentioning

confidence: 99%

Adult ocular medulloepithelioma diagnosed by transscleral fine needle aspiration: A case report

Mahdjoubi

Cassoux

Lévy-Gabriel

et al. 2017

Diagnostic Cytopathology

Self Cite

View full text Add to dashboard Cite

Ocular medulloepithelioma (ME) is a rare congenital tumor which occurs usually during childhood but is also reported in adults. They have seen an intraocular tumor in an 89 years-old female with a history of small cell lung carcinoma. Transscleral fine needle aspiration was performed. Aspirates were rich and composed of two distinctive populations of cells. The first consisted of epithelioid large cohesive cells with rare rosettes. Nuclei were oval and chromatin was delicate with small nucleoli. The second population consisted of smaller and dispersed cells with regular nuclei and dusty chromatin. Immunohistochemistry performed on paraffin-embedded cell block sections showed that the larger cells and rosettes were cytokeratin AE1/AE3, Synaptophysin, Chromogranin A, CD56, NSE, and EMA positive, whereas the smaller cells were always negative. Interestingly smaller cells expressed only weak nuclear positivity for TTF1, whereas larger cells were TTF1 negative. Melanocytic markers were negative in both populations. Morphological patterns and immunohistochemical staining confirmed ocular ME and allowed to exclude pulmonary metastasis or primary malignant melanoma. The patient was successfully treated by brachytherapy alone and is alive and well 10 months after treatment. Diagn. Cytopathol. 2017;45:561-564. © 2017 Wiley Periodicals, Inc.

show abstract

“…1 Other reports had similar findings. 2 Recently, reports have claimed successful treatment with resection and adjuvant brachytherapy 3 or brachytherapy alone 4 using the radioisotope Iodine-125. We evaluated our recent series of cases treated with Ruthenium-106 plaque brachytherapy in the primary management of medulloepithelioma.…”

mentioning

confidence: 99%

“…Two reports described its use as an adjuvant therapy after PLSU in three patients. 2,3 Only in one such instance was it possible to avoid subsequent enucleation. 3 Another case report described the situation where the medulloepithelioma responded to iodine-125 brachytherapy, avoiding planned PLSU.…”

mentioning

confidence: 99%