Conservative Surgical Treatment of Low-Grade Urothelial Carcinoma in the Renal Allograft Recipient: A Case Report

Mokos, Ivica; Pasini, Josip; Štern-Padovan, Ranka; Mrsić, Sanja; Ries, Sunčica

doi:10.1016/j.transproceed.2006.02.085

Cited by 14 publications

(13 citation statements)

References 7 publications

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“…Cytopathological and genetic findings confirmed that the tumor arose from recipient urothelium and was not transferred by the donor. After 1-year followup, the patient maintained a normal renal function and was free of tumor recurrence [14]. …”

Section: Discussionmentioning

confidence: 99%

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Transitional Cell Carcinoma of the Kidney Graft: An Extremely Uncommon Presentation of Tumor in Renal Transplant Recipients

Hevia

Gómez

Álvarez

et al. 2013

Case Reports in Transplantation

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Purpose. Transitional cell carcinoma (TCC) affecting the graft after renal transplantation is a very infrequent way of presentation of this tumor. Our aim is to present our single institution experience with 2 cases, as well as to perform a review of the literature about this tumor after the transplant. Materials and Methods. TCC of the graft developed in 2 of 1365 patients from 1977 to 2010, both cases in women. Data were analyzed for incidence, clinical presentation, treatment, and outcomes. Results. Both cases occurred in 2 mid-age women and resulted to be high grade and locally advanced TCCs, representing an incidence of 0,14% (2/1365). Clinical presentation was urinary obstruction for the first case and incidental ultrasound finding for the second. Preoperative staging was made with CT, cytology, pyelography, ureterorenoscopy, and biopsy. Treatment performed was nephroureterectomy of the graft with bladder cuff and regional lymphadenectomy. Pathological examination showed in both cases a locally advanced and high grade urothelial carcinoma of the pelvis allograft. After 24 and 14 months of followup, both patients are disease free. Conclusions. TCC of the kidney graft is an infrequent tumor that has only been reported in a few cases in the literature. It usually appears at a lower age, more often locally advanced, and with poor differentiation. A multidisciplinary approach to treatment should be required in these cases.

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Section: Discussionmentioning

confidence: 99%

“…Other locations reported in some articles are the urethra and the renal allograft, but much more infrequently. Actually, as commented previously, only a few cases of urothelial cancer in the allograft have been reported in the literature [6, 9, 14, 19, 20]. …”

Section: Discussionmentioning

confidence: 99%

Transitional Cell Carcinoma of the Kidney Graft: An Extremely Uncommon Presentation of Tumor in Renal Transplant Recipients

Hevia

Gómez

Álvarez

et al. 2013

Case Reports in Transplantation

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“…Cytogenetic observation showed that the tumor originated from the recipient. [19] The mutagenic effect of environmental toxins lasts for decades [20] and the antireflux technique during the implantation procedure may not be a sufficient barrier against seeding of malignant cells.…”

Section: Discussionmentioning

confidence: 99%

Urothelial Cancer in Patients with Endemic Balkan Nephropathy (EN) after Renal Transplantation

et al. 2007

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“…There was no lymph node metastasis. To clarify whether the carcinoma cells originated from the donor or the recipient, we performed dual-color fluorescent in situ hybridization (FISH) using a CEP X and CEP Y probe cocktail (Vysis, Abbott Molecular, IL, USA) (8,9). Single separate orange (chromosome X) and green (chromosome Y) signals were identified in the nuclei of carcinoma cells from the renal pelvis tumors of the allograft kidney and bladder tumors of the native bladder.…”

Section: Case Reportmentioning

confidence: 99%

Concurrent Urothelial Carcinoma in the Renal Pelvis of an Allograft Kidney and Native Recipient Bladder: Evidence of Donor Origin

Takaoka

Miyazaki

Kimura

et al. 2014

Japanese Journal of Clinical Oncology

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A 44-year-old woman was admitted to the hospital for asymptomatic gross hematuria. At the age of 28, she underwent transplantation of a kidney from her father for end-stage renal disease secondary to rapidly progressive glomerulonephritis. She resumed peritoneal dialysis when the allograft kidney stopped functioning at the age of 42. Dialysis was continued for the next 2 years, when the hematuria occurred and she was readmitted. Radiologic evaluation and transurethral resection of the bladder tumor revealed a tumor of the renal pelvis of the allograft kidney (cT3N0M0) and multiple bladder tumors (cT1N0M0). Total cystectomy and allograft nephroureterectomy were performed. Histopathological examinations revealed high grade urothelial carcinoma in the renal pelvis of the allograft kidney (pT3) and native bladder (pT1). Fluorescence in situ hybridization of both specimens demonstrated that the renal pelvic tumors and bladder cancer possessed XY karyotypes. These results indicated that the urothelial carcinoma developed de novo in the renal pelvis of the allograft kidney and was implanted into the recipient's native bladder.

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Conservative Surgical Treatment of Low-Grade Urothelial Carcinoma in the Renal Allograft Recipient: A Case Report

Cited by 14 publications

References 7 publications

Transitional Cell Carcinoma of the Kidney Graft: An Extremely Uncommon Presentation of Tumor in Renal Transplant Recipients

Transitional Cell Carcinoma of the Kidney Graft: An Extremely Uncommon Presentation of Tumor in Renal Transplant Recipients

Urothelial Cancer in Patients with Endemic Balkan Nephropathy (EN) after Renal Transplantation

Concurrent Urothelial Carcinoma in the Renal Pelvis of an Allograft Kidney and Native Recipient Bladder: Evidence of Donor Origin

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