Mitral valve prolapse is a benign condition. Mitral regurgitation is only
complicated in patients with severe mitral valve prolapse. Women with mitral
valve prolapse in the absence of other cardiovascular disorders tolerate
pregnancy well and do not develop remarkable cardiac complications.
Nevertheless, serious complications of mitral valve prolapse, including
arrhythmia, infective endocarditis and cerebral ischemic events, can be present
in pregnancy. Debates remain with regard to the use of prophylactic antibiotics
and β-blockers in the pregnant women with mitral valve prolapse. The
prognosis of the pregnant patients might be closely related to the pathological
and (or) functional changes of the mitral valve. Non-myxomatous mitral valve
prolapse poses no or little obstetric risks in terms of pregnancy, labor and
neonatal complications; whereas myxomatous mitral valve prolapse is a major
etiology of valvular heart disease in women of childbearing age. In the pregnant
patients with mitral valve prolapse progressing into major complications,
surgical interventions are considered. Medicinal treatment of such patients with
β-blockers should be a concern for the fetal safety.