Conservative management of mesenchymal hamartoma of the liver

Barnhart, Douglas C.; Hirschl, Ronald B.; Garver, Kimberly A.; Geiger, James D.; Harmon, Carroll M.; Coran, Arnold G.

doi:10.1016/s0022-3468(97)90574-1

Cited by 70 publications

(24 citation statements)

References 6 publications

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“…Much of the debate would stem from the uncertain natural history and progression of these tumours. Multiple reports of spontaneous regression [13][14][15][16] conflict directly with reports of recurrence, and malignancy [17][18][19]. These factors together with the often difficult and complex surgery have led to a more conservative approach in the management of these lesions, involving partial resection, cyst drainage and cyst marsupialisation [20][21][22].…”

Section: Discussionmentioning

confidence: 99%

Difficulties in the management of mesenchymal hamartomas

et al. 2008

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Section: Discussionmentioning

confidence: 99%

Difficulties in the management of mesenchymal hamartomas

et al. 2008

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“…While there is no question about the therapeutic strategy in a patient with potentially resectable UES, conservative management of MHL has in the past been advocated, since there is a potential for spontaneous regression [36]. A lesson should perhaps be learned from the parallel scenario in which cystic pleuropulmonary blastoma (PPB) may radiologically and macroscopically resemble cystic adenomatoid malformation (CCAM).…”

Section: Discussionmentioning

confidence: 99%

Undifferentiated Embryonal Sarcoma with Unusual Features Arising within Mesenchymal Hamartoma of the Liver: Report of a Case and Review of the Literature

O’Sullivan

Swanson

Knoll

et al. 2001

Pediatric and Developmental Pathology

125

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Undifferentiated embryonal sarcoma (UES) is a rare and highly malignant hepatic neoplasm, affecting almost exclusively the pediatric population. It has replaced malignant mesenchymoma, under which diagnostic term the first three cases were described. A link between embryonal sarcoma and mesenchymal hamartoma of the liver (MHL) has long been proposed, because of clinicopathologic overlaps of these entities; however, until recently, this association remained tenuous. Cases of UES arising in a background of mesenchymal hamartoma of the liver have previously been reported in two teenage girls. Discovery of a similar genetic abnormality in MHL and UES has clinched the supposed link between them. There have also been two reports of UES with prominent cystification, one associated with peripheral eosinophilia, and thereby masquerading as hydatid cyst of the liver. We report a case of UES arising in a young boy with MHL, with unusual histologic features, including large mesothelial-lined cysts and ectopic adrenal cortical tissue under Glisson's capsule.

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“…The exception to this is a single case reported by Corbally and Spitz where a UES developed 8 years after an incomplete resection of MHL [16]. MHL has the potential to involute to varying degrees spontaneously, as demonstrated by Barnhart et al and Leary et al [17,18], who described three such cases. This therefore may prompt a more conservative approach to asymptomatic lesions [15].…”

Section: Discussionmentioning

confidence: 93%