Conservative excisional laser conization for early invasive cervical cancer

Outcome of Conservatively Treated Microinvasive Squamous Cell Carcinoma of the Uterine Cervix During a 10-Year Follow-up

“…5,14,15 Our results showed a strong association between LVSI and disease persistence ( Table 6), implicating that the difficulties and inaccuracies encountered in the histological assessment of this variable in the routine diagnosis do not obscure its true clinical significance. Interestingly, we also found a 0% prevalence of LVSI among lesions less than 1 mm deep, and a greater prevalence (50.9%) observed for cases with 3.1 to 5.0 mm invasion.…”

Do FIGO Stage IA and Small (≤2 cm) IB1 Cervical Adenocarcinomas Have a Good Prognosis and Warrant Less Radical Surgery?

“…Stage IA1 cervical squamous cell carcinomas are routinely treated by local excision, and in some institutions, IA2 and even small IB1 squamous carcinomas are managed in this manner if fertility preservation is an issue. 5 In such cases, more than one local excision may be necessary to ensure that the margins are clear of invasive and preinvasive disease. However, there is much less consensus regarding the optimal management and safety of undertaking less radical surgery for small cervical adenocarcinomas.…”

“…4 The management of cervical cancer continues to evolve with new approaches and a tendency to less radical surgery, especially for International Federation of Gynecology and Obstetrics (FIGO) stage IA and even, in some institutions, small IB1 squamous carcinomas. 5 Less is known about the optimal management of small cervical adenocarcinomas. There is a tendency to more radical surgery because there is a widespread belief that adenocarcinomas behave more aggressively than squamous carcinomas and that skip lesions and extension high up the endocervical canal are common.…”

Diagnostic and therapeutic cold knife conization for cervical intraepithelial neoplasia

“…The cure rate was 98.9%, while the failure rate was only 1.1%. Rates of residual or recurrent disease after incomplete removal of CINIII with different excisional techniques have been reported as 5%-22% [14,[16][17][18] . Positive margins do not equate to residual disease, and regular followup colposcopy and cytological examination should be performed to identify the small number of women with residual CIN after therapy [14,18] .…”

“…Within 3-5 years of follow-up, the other 2 patients who only underwent conization did not have recurrence. Lü et al [29] demonstrated that microinvasive cancer was found unexpectedly in up to 11.8% of specimens through conization, and Ueda et al [17,30] reported the excellent therapeutic effects of laser conization with vaporization of the base for micro-invasive cancer. This means that conization for patients with early invasive cancer is likely to be a curative method.…”