Conservation of Salmonella Infection Mechanisms in Plants and Animals

Schikora, Adam; Virlogeux-Payant, Isabelle; Bueso, Eduardo; García, Ana Victoria Torres; Nilau, Theodora; Charrier, Amélie; Pelletier, Sandra; Menanteau, Pierrette; Baccarini, Manuela; Velge, Philippe; Hirt, Heribert

doi:10.1371/journal.pone.0024112

Cited by 108 publications

(171 citation statements)

References 51 publications

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“…have been previously reported in 16S rRNA surveys of root nodules of wild legumes 32,33 . There is mounting evidence that human-pathogenic enteric bacteria such as Salmonella can colonize plant tissues, and use similar mechanisms for infection of animal and plant hosts 34,35 . Our findings (and additional examples discussed in Supplementary Note) serve to further underscore the impact of broadening the phylogenomic R e s o u R c e representation of public databases, in this case, in adding to complementary cultivation-independent efforts to explore the breadth of microbial diversity and ecology.…”

Section: Improved Taxonomic Assignment Of Metagenomic Sequencesmentioning

confidence: 99%

1,003 reference genomes of bacterial and archaeal isolates expand coverage of the tree of life

et al. 2017

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We present 1,003 reference genomes that were sequenced as part of the Genomic Encyclopedia of Bacteria and Archaea (GEBA) initiative, selected to maximize sequence coverage of phylogenetic space. These genomes double the number of existing type strains and expand their overall phylogenetic diversity by 25%. Comparative analyses with previously available finished and draft genomes reveal a 10.5% increase in novel protein families as a function of phylogenetic diversity. The GEBA genomes recruit 25 million previously unassigned metagenomic proteins from 4,650 samples, improving their phylogenetic and functional interpretation. We identify numerous biosynthetic clusters and experimentally validate a divergent phenazine cluster with potential new chemical structure and antimicrobial activity. This Resource is the largest single release of reference genomes to date. Bacterial and archaeal isolate sequence space is still far from saturated, and future endeavors in this direction will continue to be a valuable resource for scientific discovery.

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Section: Improved Taxonomic Assignment Of Metagenomic Sequencesmentioning

confidence: 99%

1,003 reference genomes of bacterial and archaeal isolates expand coverage of the tree of life

et al. 2017

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“…These mutants also induced more apparent symptoms in Arabidopsis plants, suggesting that, in this case, T3SSs are necessary to prevent the hypersensitive response. In fact, transcriptomic analysis indicated that 649 host genes are induced specifically by the T3SS1 mutant, and many of these genes encode proteins related to responses against pathogens [170]. Consistent with this idea, wild-type bacteria, but not a T3SS1 mutant, were able to suppress the oxidative burst and the increase in extracellular pH after inoculation of a tobacco cell culture [171].…”

Section: Salmonella In Plantsmentioning

confidence: 80%

“…Interestingly, components of Salmonella T3SS1 also appear to be recognized by plants, since mutants lacking this system (spaS or sipB mutants) exhibit increased colonization of alfalfa roots and wheat seedlings [169]. These results contrast with the reduced proliferation observed for mutants prgH and ssaV, lacking T3SS1 and T3SS2, respectively, in Arabidopsis thaliana [170]. These mutants also induced more apparent symptoms in Arabidopsis plants, suggesting that, in this case, T3SSs are necessary to prevent the hypersensitive response.…”

Section: Salmonella In Plantsmentioning

confidence: 99%

Impact ofSalmonella entericaType III Secretion System Effectors on the Eukaryotic Host Cell

Ramos‐Morales

2012

ISRN Cell Biology

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Type III secretion systems are molecular machines used by many Gram-negative bacterial pathogens to inject proteins, known as effectors, directly into eukaryotic host cells. These proteins manipulate host signal transduction pathways and cellular processes to the pathogen's advantage. Salmonella enterica possesses two virulence-related type III secretion systems that deliver more than forty effectors. This paper reviews our current knowledge about the functions, biochemical activities, host targets, and impact on host cells of these effectors. First, the concerted action of effectors at the cellular level in relevant aspects of the interaction between Salmonella and its hosts is analyzed. Then, particular issues that will drive research in the field in the near future are discussed. Finally, detailed information about each individual effector is provided.

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“…Even though some studies demonstrated that Salmonella involves its virulence genes in the interactions with plants, and that under some conditions it can elicit disease-like signs in plants (Schikora et al, 2011), it is not commonly considered a phytopathogen (Barak and Schroeder, 2012). Therefore, for the purpose of this article, we broadly define "susceptibility" of tomatoes as being conducive to proliferation of Salmonella following an infection into a shallow wound in the fruit epidermis.…”

Section: Resultsmentioning

confidence: 99%

Effects of nitrogen and potassium fertilization on the susceptibility of tomatoes to post-harvest proliferation of Salmonella enterica

Marvasi¹,

George²,

Giurcanu³

et al. 2014

Food Microbiology

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a b s t r a c tFresh fruits and vegetables are increasingly recognized as vehicles of salmonellosis. Pre-and post-harvest environmental conditions, and physiological, and genetic factors are thought to contribute to the ability of human pathogens to persist in the production environment, attach to, colonize and proliferate in and on raw produce. How field production conditions affect the post-harvest food safety outcomes is not entirely understood. This study tested how varying nitrogen and potassium fertilization levels affected the "susceptibility" of tomatoes to Salmonella infections following the harvest of fruits. Two tomato varieties grown over three seasons under high, medium, and low levels of nitrogen and potassium fertilization in two locations were inoculated with seven strains of Salmonella. Even though the main effects of nitrogen and potassium fertilization on the susceptibility of tomatoes to infections with Salmonella enterica were not statistically significant overall, differences in nitrogen concentrations in plant tissues correlated with the susceptibility of partially ripe tomatoes (cv. Solar Fire) to Salmonella. Tomato maturity and the season in which tomatoes were produced had the strongest effect on the ability of Salmonella to multiply in tomatoes. Tomato phenolics, accumulation of which is known to correlate with rates of the N fertilization, did not inhibit growth of Salmonella in vitro.

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Conservation of Salmonella Infection Mechanisms in Plants and Animals

Cited by 108 publications

References 51 publications

1,003 reference genomes of bacterial and archaeal isolates expand coverage of the tree of life

1,003 reference genomes of bacterial and archaeal isolates expand coverage of the tree of life

Impact ofSalmonella entericaType III Secretion System Effectors on the Eukaryotic Host Cell

Effects of nitrogen and potassium fertilization on the susceptibility of tomatoes to post-harvest proliferation of Salmonella enterica

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