Conservation laryngeal surgery for selected pyriform sinus cancer.

Plouin‐Gaudon, Isabelle; Lengelé, Benoît; Desuter, Gauthier; Rombaux, Philippe; Ledeghen, S.; Grégoire, Vincent; Hamoir, Marc

doi:10.1016/j.ejso.2004.08.011

Cited by 35 publications

(21 citation statements)

References 29 publications

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“…Several authors have reported results of laryngeal preservation surgery for selected patients [14–17]. Though these reports also include node-positive disease, and it would be difficult to compare the long-term efficacy and local control rate with our result, they seemed to obtain comparable local control rates.…”

Section: Discussionmentioning

confidence: 47%

Radiotherapy for Stage I or II hypopharyngeal carcinoma

Nishimura

Sasaki

Yoshida

et al. 2012

Journal of Radiation Research

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Hypopharyngeal squamous cell carcinoma (HPSCC) is usually diagnosed at an advanced stage, and early-stage HPSCC is relatively rare. Because of the rarity of early-stage HPSCC, few reports have been published on the efficacy of radiotherapy (RT) in its treatment. We retrospectively reviewed the clinical records of 45 consecutive patients with Stage I and II HPSCC from May 1991 to June 2010. Patient characteristics were as follows: median age, 66 years (range, 44–90 years); male/female, 39/6; and T1/T2, 27/18. The irradiation dose ranged from 60 to 72 Gy (median: 70 Gy). Of the 45 patients, 21 underwent concurrent chemotherapy. With a median follow-up period of 62 months, the 5-year overall survival rate was 81%. Local failure occurred in 5 patients, and the 5-year local control rate was 83%. All local recurrences were successfully salvaged by surgery. The 5-year functional larynx preservation rate was 92%. Acute toxicity was manageable. Grade 3 laryngeal edema and Grade 3 hypothyroidism occurred in 1 patient each. No other late adverse events of Grade 3 or greater were observed. Based on these results, RT seemed to be an effective treatment modality for early HPSCC, with favorable organ preservation and acceptable adverse events. Early detection and accurate management of local recurrence and second malignancy was deemed to be critical.

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Section: Discussionmentioning

confidence: 47%

Radiotherapy for Stage I or II hypopharyngeal carcinoma

Nishimura

Sasaki

Yoshida

et al. 2012

Journal of Radiation Research

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“…Conservation surgery is rarely considered suitable for hypopharyngeal carcinoma, for oncological reasons and for patient-associated factors, such as, an inadequate pulmonary reserve or a postoperative swallowing disorder. Nevertheless, Plouin-Gaudon et al [7] reported 5-year overall and disease-specific survival rates of 50 and 65%, respectively, and successful laryngeal function preservation with local control in 80% of patients with selected pyriform sinus cancer. Pharyngolaryngeal reconstruction remains a surgical challenge.…”

Section: Discussionmentioning

confidence: 95%

Fasciocutaneous free flap reconstruction for squamous cell carcinoma of the hypopharynx

Joo

Sun

Cho

et al. 2010

Eur Arch Otorhinolaryngol

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The purpose of this study was to examine functional and surgical outcomes after fasciocutaneous free flap reconstruction of the hypopharynx. A retrospective review of the records of 48 consecutive patients that underwent hypopharyngectomy and reconstruction using fasciocutaneous free flaps between 1996 and 2009 was performed. Flap donor sites included the radial forearm (n = 42), anterolateral thigh (n = 5), and lateral thigh (n = 1). There was no perioperative mortality, and the free flap survival rate was 95.8%. Five (10.4%) patients developed a postoperative pharyngocutaneous fistula. In three (6.3%) patients a stricture developed during the postoperative period. Forty-four (92%) patients were decannulated and maintained their voice. Forty-four (92%) patients were able to take oral nutrition, although 4 (8%) needed additional PEG-tube feeding. Five-year overall and disease-specific survival rates were 56 and 61%, respectively. Functional reconstruction of extensive laryngohypopharyngeal defects can be achieved using fasciocutaneous free flaps with favorable functional and surgical results.

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“…More extensive pyriform lesions are resectable, sparing the larynx, provided that reconstruction was achieved using free flaps . We report the long‐term results of 2 surgical techniques performed in a selected series of patients with pyriform sinus carcinoma with, as main objective, locoregional control and functional laryngeal preservation.…”

Section: Discussionmentioning

confidence: 99%