Conservation and polymorphism of EBV RPMS1 gene in EBV-associated tumors and healthy individuals from endemic and non-endemic nasopharyngeal carcinoma areas in China

Wu, Shuo; Li, Wen; Li, Hong; Zhao, Zhenzhen; Yang, Yang; Xiao, Hua; Song, Yingying; Luo, Bing

doi:10.1016/j.virusres.2018.04.009

Cited by 13 publications

(28 citation statements)

References 29 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Comparison of EBV sequences from North and South China identified this SNP; the consequent Asp-to-Asn amino acid change in the RPMS1 protein was found to reduce the stability of the protein ( 10 ), although uncertainty remains about whether the RPMS1 protein is expressed in EBV-infected cells ( 11 ). A further sequence study supported this distribution of the SNP selectively in southern China ( 12 ). In our data, 95% of NPC samples from China and Hong Kong had this G155391A SNP ( Fig.…”

Section: Resultsmentioning

confidence: 54%

Sequence Variation of Epstein-Barr Virus: Viral Types, Geography, Codon Usage, and Diseases

Correia¹,

Bridges²,

Wegner

et al. 2018

J Virol

101

View full text Add to dashboard Cite

Epstein-Barr virus causes most cases of infectious mononucleosis and posttransplant lymphoproliferative disease. It contributes to several types of cancer, including Hodgkin's lymphoma, Burkitt's lymphoma, diffuse large B cell lymphoma, nasopharyngeal carcinoma, and gastric carcinoma. EBV genome variation is important because some of the diseases associated with EBV have very different incidences in different populations and geographic regions, and differences in the EBV genome might contribute to these diseases. Some specific EBV genome alterations that appear to be significant in EBV-associated cancers are already known, and current efforts to make an EBV vaccine and antiviral drugs should also take account of sequence differences in the proteins used as targets.

show abstract

Section: Resultsmentioning

confidence: 54%

Sequence Variation of Epstein-Barr Virus: Viral Types, Geography, Codon Usage, and Diseases

Correia¹,

Bridges²,

Wegner

et al. 2018

J Virol

101

View full text Add to dashboard Cite

show abstract

“…8,14,15 Of interest though, in our available data, most patients with NPC had a negative EBV result. It has been reported in numerous studies that the incidence of EBV-associated NPC appears to be related geographically 1,15,16 . The study conducted by Xu et al 1 found that the BALF2-CCT gene is a highly pathogenic EBV subtype associated with NPC and shows the strongest association with the region.…”

Section: Discussionmentioning

confidence: 99%

Clinical characteristics and survival outcomes of ascending, descending and mixed types of nasopharyngeal carcinoma in the non‐endemic areas of china: A propensity score matching analysis

et al. 2020

View full text Add to dashboard Cite

show abstract

“…Therefore, based on this close relationship, EBV DNA or antibodies can be used as an early diagnostic tool to screen for patients with NPC. In recent years, the A157154C polymorphism of the A73 gene and the RPMS1 genotype of EBV have been identified for their susceptibility to NPC (60,61). In particular, the combination of EBV-viral capsid antigen (VCA) IgA and EBV-early antigen IgA showed better sensitivity and specificity than EBV-DNA in screening NPC high-risk family individuals (62).…”

Section: Npc Biomarkers Discovered Through Genomicsmentioning

confidence: 99%

Research status and prospects of biomarkers for nasopharyngeal carcinoma in the era of high‑throughput omics (Review)

et al. 2021

View full text Add to dashboard Cite

As a malignant tumor type, nasopharyngeal carcinoma (NPC) is characterized by distinct geographical, ethnic and genetic differences; presenting a major threat to human health in many countries, especially in Southern China. At present, no accurate and effective methods are available for the early diagnosis, efficacious evaluation or prognosis prediction for NPC. As such, a large number of patients have locoregionally advanced NPC at the time of initial diagnosis. Many patients show toxic reactions to overtreatment and have risks of cancer recurrence and distant metastasis owing to insufficient treatment. To solve these clinical problems, high-throughput '-omics' technologies are being used to screen and identify specific molecular biomarkers for NPC. Because of the lack of comprehensive descriptions regarding NPC biomarkers, the present study summarized the research progress that has been made in recent years to discover NPC biomarkers, highlighting the existing problems that require exploration. In view of the lack of authoritative reports at present, study design factors that affect the screening of biomarkers are also discussed here and prospects for future research are proposed to provide references for follow-up studies of NPC biomarkers.

show abstract

Conservation and polymorphism of EBV RPMS1 gene in EBV-associated tumors and healthy individuals from endemic and non-endemic nasopharyngeal carcinoma areas in China

Cited by 13 publications

References 29 publications

Sequence Variation of Epstein-Barr Virus: Viral Types, Geography, Codon Usage, and Diseases

Sequence Variation of Epstein-Barr Virus: Viral Types, Geography, Codon Usage, and Diseases

Clinical characteristics and survival outcomes of ascending, descending and mixed types of nasopharyngeal carcinoma in the non‐endemic areas of china: A propensity score matching analysis

Research status and prospects of biomarkers for nasopharyngeal carcinoma in the era of high‑throughput omics (Review)

Contact Info

Product

Resources

About