Consequential Late Effects up to 10 years Following Primary and Postoperative Radiotherapy for Prostate Cancer

Abstract

patients that signed consent forms and completed the baseline a self-addressed ability to participate in social roles and activities were included in this exploratory analysis. At the time of RT commencement, the mean score of was 16.2 [95%CI 15.675-16.725] .Chemo types (adjuvant chemo vs. no chemo, OR Z 0.935, 95% CI: 0.882-1, p Z 0.036) and chemo regimens (taxane vs. no chemo, OR Z 0.905, 95% CI: 0.84 e 0.978, p Z 0.01) were significantly associated with Ability to participate in social roles and activities at baseline, while age, menopausal status, margin, pathologic stage, and the use of anti-Her2 target therapy were not. Of 148 patients completed questionnaires after therapy, the mean score was 16.0[95%CI 15.464-16.671], which was not significant different from the baseline (p > 0.05). Conclusion: Ability to participate in social roles and activities is generally good in breast cancer patients receiving radiation therapy. Adjuvant chemotherapy with taxane seemed to be a risk factor for ability to participate in social roles and activities in patients with breast cancer, radiation therapy did not alter this QOL measure. In addition to validate these findings, future study shall investigate the effect of ability to participate in social roles and activities on long-term survival and define approaches of improvement to improve quality of life in patients with breast cancer.