Consequences of Venezuela's massive migration crisis on imported malaria in Colombia, 2016–2018

Rodríguez‐Morales, Alfonso J.; Suárez, José Antonio; Rísquez, Alejandro; Villamil-Gómez, Wilmer E.; Paniz‐Mondolfi, Alberto

doi:10.1016/j.tmaid.2019.02.004

Cited by 31 publications

(16 citation statements)

References 5 publications

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“…However, in Colombia, the migration trend from Venezuela to Colombia has increased the number of imported cases of malaria, particularly in the last 3 years. 3 Malaria is typically transmitted to humans by the bite of infected Anopheles mosquitoes. 4 Less commonly, malaria may also be acquired by blood transfusions, by sharing contaminated needles and syringes, via mother-to-child transmission, or after solid organ transplantation (SOT).…”

Section: Backg Rou N Dmentioning

confidence: 99%

Transmission of malaria from donors to solid organ transplant recipients: A case report and literature review

Rosso

Rojas

Gil

et al. 2021

Transplant Infectious Dis

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Malaria is a febrile and potentially fatal infection. It is typically transmitted to humans through the bite of Anopheles mosquitoes and less frequently can be contracted through blood transfusions, sharing contaminated needles and syringes, mother-tochild transmission, or after solid organ transplantation. Posttransplant malaria has rarely been reported in the literature, even in endemic areas. We report the cases of three solid organ recipients in which Plasmodium vivax infection was documented during postsurgical evaluation 30 days after transplant surgery.

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Section: Backg Rou N Dmentioning

confidence: 99%

Transmission of malaria from donors to solid organ transplant recipients: A case report and literature review

Rosso

Rojas

Gil

et al. 2021

Transplant Infectious Dis

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“…Due to the socio-economic and humanitarian conditions in Venezuela, since 2014 migration has increased with an estimated two million people moving to neighboring nations such as Colombia, Ecuador, Chile, Brazil, Argentina, and Perú (28), countries where, in recent years, an increase in malaria cases has been reported. In 2017 and 2018, Colombia registered 2,048 new P. vivax malaria cases imported from Venezuela (29).…”

Section: Circuitsmentioning

confidence: 99%

Characterization of an outbreak of malaria in a non-endemic zone on the coastal region of Ecuador

2021

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Introduction: Malaria is a vector-borne disease widely distributed in the Amazon region and the coastal area of northern Ecuador. Its epidemiology involves related factors such as human settlements, vector reproduction sites, mobility, productive activity, and the response capacity of health systems, among others.Objective: To describe malaria transmission by Plasmodium vivax in a non-endemic area of Ecuador by analyzing the epidemiological and entomological factors involved.Materials and methods: We conducted the epidemiological study of the cases reported in the Salinas canton and the characterization of vector breeding sites through captures of larvae and adult mosquitoes by human capture of resting mosquitoes.Results: We detected 21 cases of malaria with local transmission related to the presence of initial cases in Venezuelan migrant patients and identified Anopheles albimanus as the predominant vector in natural breeding sites such as estuaries, wells, and water channels.Conclusions: We detected an outbreak of malaria triggered by imported cases from Venezuela. Climatic, social, environmental, and ecological conditions have favored the development of the vector maintaining the transmission cycle. Strategies to control imported malaria should be multiple including early case detection and control of productive breeding sites to avoid local transmission.

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“…Malaria epidemiology in Colombia is associated with a multitude of ecological, evolutionary and social factors, including human migration due to deforestation, illegal crops, gold mining [18][19][20][21][22], and the mass emigration of people fleeing the humanitarian crisis in Venezuela [23][24][25][26]. Understanding the interplay between e.g.…”

Section: Plos Geneticsmentioning

confidence: 99%

Identity-by-descent with uncertainty characterises connectivity of Plasmodium falciparum populations on the Colombian-Pacific coast

et al. 2020

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Characterising connectivity between geographically separated biological populations is a common goal in many fields. Recent approaches to understanding connectivity between malaria parasite populations, with implications for disease control efforts, have used estimates of relatedness based on identity-by-descent (IBD). However, uncertainty around estimated relatedness has not been accounted for. IBD-based relatedness estimates with uncertainty were computed for pairs of monoclonal Plasmodium falciparum samples collected from five cities on the Colombian-Pacific coast where long-term clonal propagation of P. falciparum is frequent. The cities include two official ports, Buenaventura and Tumaco, that are separated geographically but connected by frequent marine traffic. Fractions of highly-related sample pairs (whose classification using a threshold accounts for uncertainty) were greater within cities versus between. However, based on both highly-related fractions and on a threshold-free approach (Wasserstein distances between parasite populations) connectivity between Buenaventura and Tumaco was disproportionally high. Buenaventura-Tumaco connectivity was consistent with transmission events involving parasites from five clonal components (groups of statistically indistinguishable parasites identified under a graph theoretic framework). To conclude, P. falciparum population connectivity on the Colombian-Pacific coast abides by accessibility not isolation-by-distance, potentially implicating marine traffic in malaria transmission with opportunities for targeted intervention. Further investigations are required to test this hypothesis. For the first time in malaria epidemiology (and to our knowledge in ecological and epidemiological studies more generally), we account for uncertainty around estimated relatedness (an important consideration for studies that plan to use genotype versus whole genome sequence data to estimate IBD-based relatedness); we also use threshold-free methods to compare parasite populations and identify clonal components. Threshold-free methods are especially important in analyses of malaria parasites and other recombining organisms with mixed mating systems where thresholds do not have clear interpretation (e.g. due to clonal propagation) and thus undermine the cross-comparison of studies.

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Consequences of Venezuela's massive migration crisis on imported malaria in Colombia, 2016–2018

Cited by 31 publications

References 5 publications

Transmission of malaria from donors to solid organ transplant recipients: A case report and literature review

Transmission of malaria from donors to solid organ transplant recipients: A case report and literature review

Characterization of an outbreak of malaria in a non-endemic zone on the coastal region of Ecuador

Identity-by-descent with uncertainty characterises connectivity of Plasmodium falciparum populations on the Colombian-Pacific coast

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