Consequences of Using Escharotic Agents as Primary Treatment for Nonmelanoma Skin Cancer

McDaniel, Shana; Goldman, Glenn D.

doi:10.1001/archderm.138.12.1593

Cited by 54 publications

(60 citation statements)

References 6 publications

(5 reference statements)

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“…The other applications of zinc chloride include protein precipitation and insulin preparation [10,11]. Literature reported that zinc chloride has been used in the treatment of cancer as a destructive agent [12] and in the pluripotency maintenance of mouse embryonic stem cell through the regulation of STAT3 signaling pathway [13]. It can be used for the palliative treatment of canine and malignant skin wounds [14].…”

Section: Introductionmentioning

confidence: 99%

Study of the Energy of Consciousness Healing Treatment on Physical, Structural, Thermal, and Behavioral Properties of Zinc Chloride

Trivedi¹

2017

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Abstract:Zinc chloride is an important pharmaceutical/nutraceutical mineral for the prevention and treatment of several diseases. The objective of the current study was to investigate the impact of The Trivedi Effect ® -Energy of Consciousness Healing Treatment (Biofield Energy Treatment) on physical, structural, thermal, and behavioral properties of zinc chloride using PXRD, PSD, FT-IR, UV-vis, and DSC analysis. Zinc chloride was divided into two parts -one part was control, while another part was treated with The Trivedi Effect ® remotely by seven renowned Biofield Energy Healers and defined as The Trivedi Effect ® treated sample. A significant alteration of the crystallite size and relative intensities of the PXRD peaks were observed in The Trivedi Effect ® treated sample with respect to the control sample. A sharp peak at 2θ equal to 51.45°, which was observed in the control sample was disappeared in the treated sample. The average crystallite size of the treated sample was decreased by 2.13% compared with the control sample. The size of the particles at d 10 , d 50 , and d 90 was decreased by 3.36%, 7.97%, and 11.51%, respectively in the treated sample compared with the control sample. The surface area of the treated sample was significantly increased by 5.69% compared with the control sample. The FT-IR spectroscopic analysis revealed that Zn-Cl stretching in the control was 646 cm -1 , whereas it was significantly shifted downward to 505 cm -1 in the treated sample. The UV-vis analysis exhibited that wavelength of the maximum absorbance (λ max ) of both the control and treated samples was at 196.4 nm. The DSC analysis exhibited that the melting and decomposition temperature were increased by 0.93% and 0.56%, respectively in the treated zinc chloride compared to the control sample. The enthalpy of fusion of the treated sample (338.27 J/g) was increased significantly by 33.84% compared with the control sample (252.75 J/g). The enthalpy of decomposition of the treated sample was increased by 3.78% compared with the control sample. The current study anticipated that The Trivedi Effect ® -Energy of Consciousness Healing Treatment might lead to produce a new polymorphic form of zinc chloride, which would be more soluble, bioavailable, and thermally stable compared with the untreated compound. The treated sample could be more stable during manufacturing, delivery or storage conditions than the untreated sample. Hence, the treated zinc chloride would be very useful to design better nutraceutical/pharmaceutical formulations that might offer better therapeutic response against inflammatory diseases, immunological disorders, aging, stress, cancer, etc.

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Section: Introductionmentioning

confidence: 99%

Study of the Energy of Consciousness Healing Treatment on Physical, Structural, Thermal, and Behavioral Properties of Zinc Chloride

Trivedi¹

2017

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“…The criticism of such treatments in medical literature generally addresses cases where individual patients refused the medical standard of care treatment in favor of self-prescribed, unsupervised treatment with an escharotic concoction purchased by the patient through the Internet. 8,9 This report provides evidence for the efficacy of escharotic treatment for CIN II, III in a case of recurrent, highgrade neoplasia following conventional cervical conization. The strength of this case emphasizes the need for clinical research to explore the long-term effectiveness and potential risks of escharotic treatment for cervical dysplasia.…”

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confidence: 72%

An Alternative Treatment for Cervical Intraepithelial Neoplasia II, III

2009

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Background. This report describes a case of a woman with progressive and recurrent cervical dysplasia 4 years after cervical conization for severe dysplasia. Patient and methods. A 20-year-old female was referred for colposcopy and biopsy following results of moderate to severe atypia of cervical cells on her Papanicolaou (Pap) test. Her colposcopy was satisfactory and her biopsy revealed cervical intraepithelial neoplasia (CIN) II, III. She refused the conventional recommendation of loop electrosurgical excision procedure (LEEP) and, as an alternative, elected to receive escharotic treatment at a frequency of 2 treatments per week for 5 weeks. In addition to the escharotic treatment she followed an oral vitamin and botanical protocol. She was followed for 5 years. Results. The patient's 4-month and 10-month follow-up Pap smears revealed negative cervical cytology for intraepithelial lesion or malignancy. Her 10-month colposcopy was satisfactory and no lesions were noted on the colposcopic exam. Liquid based Pap results continued to remain normal for 5 years after the initiation of treatment. Discussion. Escharotic treatment of high-grade cervical neoplasias with satisfactory colposcopy holds promise as an effective and low-risk alternative therapy to LEEP and other excisional procedures.

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“…Each ingredient already has been proven for its potential activity on skin health as evidenced through use in various medicines as well as cosmeceuticals. Zinc is an essential cofactor of various metalloenzymes and it protects the skin from UV irradiation and has been used as a destructive agent for the management of cancer [7,8]. Sodium selenate enhances the repair system of DNA segments and reduces the risk of new cancer development [9,10].…”

Section: Shirley Theresa Holmlundn Et Al: Skin Nourishing Effects Ofmentioning

confidence: 99%

Skin Nourishing Effects of Biofield Energy Healing Treatment Based Herbomineral Formulation

Holmlund¹,

Trivedi²,

Branton³

et al. 2017

EJPM

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Abstract:The aim of the present study was undertaken to evaluate the effects of a Consciousness Energy Healing (The Trivedi Effect ® ) Treatment based test formulation on skin health. The test formulation and DMEM were separated into two parts. One part of each received the Consciousness Energy Healing Treatment by Shirley Theresa Holmlund and were termed as the Biofield Energy Treated samples, while the other parts were considered as the untreated test samples. MTT assay showed more than 70% cells were viable in all the tested concentrations in three cell lines and that the test formulation was safe and nontoxic. The percent cell proliferation using BrdU assay was significantly increased by 343.57%, 100.29%, and 132.6% in the UT-DMEM + BT-Test formulation, BT-DMEM + UT-Test formulation, and BT-DMEM + BT-Test formulation groups, respectively at 8.75 µg/mL compared to the UT-DMEM + UT-Test formulation group. The collagen synthesis was significantly increased by 5.94% and 10.84% in the UT-DMEM + BT-Test formulation and BT-DMEM + BT-Test formulation groups, respectively at 0.625 µg/mL with respect to the untreated group. Elastin level was significantly (p≤0.001) increased by 15.95%, 58.31%, and 47.18% at 2.5 µg/mL in the UT-DMEM + BT-Test formulation, BT-DMEM + UT-Test formulation, and BT-DMEM + BT-Test formulation groups, respectively compared to the untreated group. The level of hyaluronic acid was significantly increased by 15.13% and 68.56% in the BT-DMEM + UT-Test formulation and BT-DMEM + BT-Test formulation groups, respectively at 0.625 µg/mL compared to the untreated group. The level of melanin was significantly reduced by 17.06%, 6.94%, and 13.07% in the UT-DMEM + BT-Test formulation, BT-DMEM + UT-Test formulation, and BT-DMEM + BT-Test formulation groups, respectively at 0.063 µg/mL compared to untreated group. The effect of skin protection upon exposure with UV-B rays displayed some alteration of the percent cell viability in all the tested groups. The wound healing activity by scratch assay exhibited significant wound closure and cell migration in the test formulation and DMEM in HFF-1 cells compared to the untreated group. Altogether, the data suggests that the Consciousness Energy Healing Treated DMEM and test formulation exhibited better skin protective responses compared to the untreated DMEM and test formulation group with respect to the skin health parameters. Therefore, the Biofield Energy Treated test formulation could be developed as a potential cosmetic product against various skin problems viz.

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Consequences of Using Escharotic Agents as Primary Treatment for Nonmelanoma Skin Cancer

Cited by 54 publications

References 6 publications

Study of the Energy of Consciousness Healing Treatment on Physical, Structural, Thermal, and Behavioral Properties of Zinc Chloride

Study of the Energy of Consciousness Healing Treatment on Physical, Structural, Thermal, and Behavioral Properties of Zinc Chloride

An Alternative Treatment for Cervical Intraepithelial Neoplasia II, III

Skin Nourishing Effects of Biofield Energy Healing Treatment Based Herbomineral Formulation

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