Consequences of subchronic exposure to ethanolic extract from fruits and leaves of Schinus molle var. areira L. in mice

Bras, Cristina; Domínguez, Sergio; Codón, Stella Maris; Minetti, Alejandra; Ferrero, Adriana Alicia

doi:10.1016/j.jep.2010.08.035

Cited by 13 publications

(8 citation statements)

References 30 publications

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“…areira was detected. This result agreed with those obtained in the FOB performed after subchronic oral exposure of this extract in mice (Bras et al, 2010). On the other hand, the hexanic extract from leaves of Schinus molle var.…”

Section: Discussionsupporting

confidence: 91%

“…doi:10.1016/j.jep.2011.08.036 ethanolic extract from leaves exhibited a diuretic and a stimulant effect after oral subchronic treatment. In addition, a tendency to decrease blood glucose in males was observed in this assay (Bras et al, 2010).…”

Section: Introductionmentioning

confidence: 55%

“…areira reflected by the increased number of rearings performed during the first 5 min of observation in the session carried out on Day 14. This same parameter was also altered after the subchronic oral exposure to this extract in mice (Bras et al, 2010), whereas, after subacute oral exposure to the ethanol extract from fruits, a hyperactive behavior in the OF was also observed (Ferrero et al, 2007a). All this evidence suggests that the different extracts of Schinus molle var.…”

Section: Discussionmentioning

confidence: 72%

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Evaluation of the acute dermal exposure of the ethanolic and hexanic extracts from leaves of Schinus molle var. areira L. in rats

Bras

Gumilar

Gandini

et al. 2011

Journal of Ethnopharmacology

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Section: Discussionsupporting

confidence: 91%

Section: Introductionmentioning

confidence: 55%

Section: Discussionmentioning

confidence: 72%

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Evaluation of the acute dermal exposure of the ethanolic and hexanic extracts from leaves of Schinus molle var. areira L. in rats

Bras

Gumilar

Gandini

et al. 2011

Journal of Ethnopharmacology

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“…molle L. (Anacardiaceae) is a species found in tropical and subtropical regions of the world, and is commonly known as aroeira-parsley, pepper spray, and anacauite, among others. Its fruits and leaves are used in traditional medicine because they have several properties related to their high contents of terpenic and phenolic compounds produced by the secondary metabolism of the plant (Hosni et al, 2011;Bras et al, 2010). Research has shown several biological activities for the essential oil and extracts of the leaves and fruits of S. molle.…”

Section: Introductionmentioning

confidence: 99%

Effect of leaf and fruit extracts of <em>Schinus molle</em> on oxidative stability of some vegetables oils under accelerated oxidation

et al. 2020

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The most highly recommended oils for the diet are those which are rich in unsaturated fatty acids. However, the presence of these components in the oils is related to oxidation, which can be determined by the induction period. Further safety and the prolongation of the storage period for such oils can be achieved by the addition of efficient antioxidants, which today are preferably from natural sources. In order to contribute to the related research, the main objective of this study was to evaluate the efficacy of Schinus molle extracts compared to synthetic antioxidants (BHT) in delaying the oxidation of some vegetable oils. The results of the present study showed that the fruit and leaf extracts of Schinus molle presented activities and potential for being used as antioxidants in vegetable oils based on the tested methods (DPPH and ABTS). The extracts were also characterized as containing phenolic compounds by the Folin Ciocalteau method and by high performance liquid chromatography (HPLC). The action of the extracts as natural antioxidants was proven in the vegetal oils of chia (Salvia hispanica) and peanut (Arachis hypogaea) by the Rancimat method. It was observed that the oils increased their resistance to oxidation when incorporated with the extracts of Schinus molle, and the extract from the leaves increased the induction period of peanut oil by more than three hours (from 19.5 to 22.9 hours) with an extract concentration of 2.5%. The fruit extract was more efficient in delaying the oxidation of chia oil, prolonging its induction period by more than one hour with a concentration of 2.5% (from 3.1 to 4.3 hours). According to the results, the extracts of Schinus molle have favorable properties for possible use as an additive which inhibits the oxidation process of the tested vegetables oils.

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“…Estudios experimentales reportan actividad antiviral, antitumoral, analgésica y antiinflamatoria. Se han identificado diversos componentes activos como los flavonoides, triterpenoides tetracíclicos, esteroles y saponinas (11) .…”

Section: Introductionunclassified

Toxicidad oral aguda de los extractos etanólicos de Eucalyptus globulus, Morinda citrifolia, Peperomia glauca, Schinus molle y Zea mays en ratones BALB/c 53

Chilón-Cornejo¹,

Arroyo-Acevedo²,

Barrera³

et al. 2018

Rev. per. med. integr.

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Objetivo. Evaluar la toxicidad aguda de los extractos etanólicos del Eucalyptus globulus Labill. (eucalipto), Morinda citrifolia L. (noni), Peperomia glauca (pino) (congona), Schinus molle L. (molle) y Zea mays L. (Maíz morado) en ratones Balb/c 53. Materiales y métodos. Se utilizaron 60 ratones machos divididos en seis grupos (eucalipto, noni, congona, molle, maíz morado y control). Los grupos tratados recibieron por vía oral una dosis única de 2000 mg/kg de los extractos etanólicos, y el grupo control recibió polisorbato 2 mL/kg al 3%. Se evaluó ganancia de peso, valores hematológicos (hematocrito, eritrocitos, hemograma, leucocitos, plaquetas), bioquímica sérica (úrea, creatinina, ALT, proteínas totales, albumina, globulinas), histopatología hepática y renal. Resultados. Se observó signos de inquietud, excitación y aparente fotosensibilidad en el grupo eucalipto, por una hora. Se encontró leucopenia en grupos congona, molle, eucalipto y maíz morado; trombocitopenia en grupos eucalipto y molle, y elevación del ALT en los grupos congona y eucalipto, en comparación con los valores del grupo control. La ganancia de peso, los demás valores hematológicos, así como la bioquímica renal y hepática en los otros grupos no fueron significativos. Conclusiones. En las condiciones experimentales no se observó signos de toxicidad ni mortalidad en el ensayo; la DL50 de los extractos etanólicos estaría sobre los 2000 mg/kg.

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Consequences of subchronic exposure to ethanolic extract from fruits and leaves of Schinus molle var. areira L. in mice

Cited by 13 publications

References 30 publications

Evaluation of the acute dermal exposure of the ethanolic and hexanic extracts from leaves of Schinus molle var. areira L. in rats

Evaluation of the acute dermal exposure of the ethanolic and hexanic extracts from leaves of Schinus molle var. areira L. in rats

Effect of leaf and fruit extracts of <em>Schinus molle</em> on oxidative stability of some vegetables oils under accelerated oxidation

Toxicidad oral aguda de los extractos etanólicos de Eucalyptus globulus, Morinda citrifolia, Peperomia glauca, Schinus molle y Zea mays en ratones BALB/c 53

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