Consequences of Screening in Lung Cancer: Development and Dimensionality of a Questionnaire

Brodersen, John; Thorsen, Hanne; Kreiner, Svend

doi:10.1111/j.1524-4733.2010.00697.x

Cited by 55 publications

(120 citation statements)

References 50 publications

(74 reference statements)

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“…28 Part II was developed in particular to measure the long-term consequences of false-positive cancer screening results. 17,22,23 Our fi ndings from this part imply that the degree of change in inner calmness and existential values within the fi rst half-year after fi nal diagnosis were just as great for women with breast cancer as for women receiving false-positive fi ndings. Furthermore, the changes in existential values within 3 years were still greater for those having false positives compared with those with normal fi ndings.…”

Section: Fa L Se-p Osi T Iv E M a M M O Gr A Phy S Cr Eeningmentioning

confidence: 78%

“…Therefore, part II of the COS-BC requires a laterally reversed scoring system: a response to "the same as before" becomes a value of "no change;" a response to "less" or "more" becomes a value of "minor change;" and a response to "much less" or "much more" becomes a value of "major change." 17,22,23 The 4 sum-scores of part II refl ect the degree of changes in the 4 long-term psychosocial outcomes, respectively. A high score in part II denotes that the individual is highly psychosocially affected, irrespective of this experience being positive or negative.…”

Section: Fa L Se-p Osi T Iv E M a M M O Gr A Phy S Cr Eeningmentioning

confidence: 99%

“…A high score in part II denotes that the individual is highly psychosocially affected, irrespective of this experience being positive or negative. 22,23 The items in the 10 scales of the COS-BC have been found invariant in relation to time by testing the items for differential item functioning. 24 Such testing ensures that repeated measurement in a longitudinal survey would be invariant, so that any change over time would be an actual change and not due to differential item functioning.…”

Section: Fa L Se-p Osi T Iv E M a M M O Gr A Phy S Cr Eeningmentioning

confidence: 99%

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Long-Term Psychosocial Consequences of False-Positive Screening Mammography

Brodersen

Siersma

2013

The Annals of Family Medicine

281

225

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PURPOSE Cancer screening programs have the potential of intended benefi cial effects, but they also inevitably have unintended harmful effects. In the case of screening mammography, the most frequent harm is a false-positive result. Prior efforts to measure their psychosocial consequences have been limited by shortterm follow-up, the use of generic survey instruments, and the lack of a relevant benchmark-women with breast cancer. METHODSIn this cohort study with a 3-year follow-up, we recruited 454 women with abnormal fi ndings in screening mammography over a 1-year period. For each woman with an abnormal fi nding on a screening mammogram (false and true positives), we recruited another 2 women with normal screening results who were screened the same day at the same clinic. These participants were asked to complete the Consequences of Screening in Breast Cancer-a validated questionnaire encompassing 12 psychosocial outcomes-at baseline, 1, 6, 18, and 36 months.RESULTS Six months after fi nal diagnosis, women with false-positive fi ndings reported changes in existential values and inner calmness as great as those reported by women with a diagnosis of breast cancer (Δ = 1.15; P = .015; and Δ = 0.13; P = .423, respectively). Three years after being declared free of cancer, women with false-positive results consistently reported greater negative psychosocial consequences compared with women who had normal fi ndings in all 12 psychosocial outcomes (Δ >0 for 12 of 12 outcomes; P <.01 for 4 of 12 outcomes).CONCLUSION False-positive fi ndings on screening mammography causes longterm psychosocial harm: 3 years after a false-positive fi nding, women experience psychosocial consequences that range between those experienced by women with a normal mammogram and those with a diagnosis of breast cancer.

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Section: Fa L Se-p Osi T Iv E M a M M O Gr A Phy S Cr Eeningmentioning

confidence: 78%

Section: Fa L Se-p Osi T Iv E M a M M O Gr A Phy S Cr Eeningmentioning

confidence: 99%

Section: Fa L Se-p Osi T Iv E M a M M O Gr A Phy S Cr Eeningmentioning

confidence: 99%

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Long-Term Psychosocial Consequences of False-Positive Screening Mammography

Brodersen

Siersma

2013

The Annals of Family Medicine

281

225

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“…Comments from participants in DLCST revealed, that many of them think of the study as an ordinary screening programme rather than a medical trial [16]. Therefore, the identification of participation bias in screening programmes is important due to eventual conclusions regarding universal validity of the results from trials.…”

Section: Introductionmentioning

confidence: 98%

Participation bias in a randomised trial of screening for lung cancer

et al. 2011

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“…The strongest designs that can provide the most useful information about psychological harms use conditionspecific measures that are responsive to the more subtle reactions that can result from screening. 8,9 They also use longitudinal designs to assess these burdens over crucial time points in the screening cascade. Cross-sectional studies or those that use only insensitive, general measures (such as the SF-36) are potentially less useful for studying screening harms.…”

Section: Introductionmentioning

confidence: 99%

The Psychological Harms of Screening: the Evidence We Have Versus the Evidence We Need

et al. 2014

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BACKGROUND: Systematic reviews for the US Preventive Services Task Force have found less high-quality evidence on psychological than physical harms of screening. To understand the extent of evidence on psychological harms, we developed an evidence map that quantifies the distribution of evidence on psychological harms for five adult screening services. We also note gaps in the literature and make recommendations for future research. METHODS: We systematically searched PubMed, PsycInfo, and CINAHL from 2002 to 2012 for studies of any research design that assessed the burden or frequency of psychological harm associated with screening for: prostate and lung cancers, osteoporosis, abdominal aortic aneurysm (AAA) and carotid artery stenosis (CAS). We also searched for studies that estimated rates of overdiagnosis (a marker for unnecessary labeling). We included studies published in English and used dual independent review to determine study inclusion and to abstract information on design, types of measures, and outcomes assessed. RESULTS: Sixty-eight studies assessing psychological harms met our criteria; 62 % concerned prostate cancer and 16 % concerned lung cancer. Evidence was scant for the other three screening services. Overall, only about one-third of the studies used both longitudinal designs and condition-specific measures (ranging from 0 % for AAA and CAS to 78 % for lung cancer), which can provide the best evidence on harms. An additional 20 studies that met our criteria estimated rates of overdiagnosis in lung or prostate cancer. No studies estimated overdiagnosis for the non-cancer screening services. DISCUSSION: Evidence on psychological harms varied markedly across screening services in number and potential usefulness. We found important evidence gaps for all five screening services. The evidence that we have on psychological harms is inadequate in number of studies and in research design and measures. Future research should focus more clearly on the evidence that we need for decision making about screening.

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Consequences of Screening in Lung Cancer: Development and Dimensionality of a Questionnaire

Cited by 55 publications

References 50 publications

Long-Term Psychosocial Consequences of False-Positive Screening Mammography

Long-Term Psychosocial Consequences of False-Positive Screening Mammography

Participation bias in a randomised trial of screening for lung cancer

The Psychological Harms of Screening: the Evidence We Have Versus the Evidence We Need

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