Consequences of sarcopenia among nursing home residents at long-term follow-up

Henwood, Timothy; Hassan, Bothaina Hussein; Swinton, Paul; Senior, Hugh; Keogh, Justin W L

doi:10.1016/j.gerinurse.2017.02.003

Cited by 34 publications

(51 citation statements)

References 30 publications

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“…A total of 52 838 individuals (48.8% females) with a mean age of the study populations ranging from 65.0 to 86.7 years were included, and sample sizes ranged from 58 to 6,658 individuals. Study populations included community‐dwelling individuals (22 studies), hospitalized patients (3 studies), outpatients (4 studies), and nursing home residents (3 studies) . Four studies included a combined group of hospitalized patients with fractures and community‐dwelling individuals without fractures .…”

Section: Resultsmentioning

confidence: 99%

“…Four studies included a combined group of hospitalized patients with fractures and community‐dwelling individuals without fractures . Two studies reported retrospective data, 20 studies were cross‐sectional, 13 studies were prospective, and 1 study was a randomized controlled trial examining the effect of nutritional supplementation on bone mineral density and risk of falls . Most of the studies were performed in Europe (12 studies), and Asia (12 studies), followed by Australia (5 studies), South America (4 studies), and North America (3 studies) .…”

Section: Resultsmentioning

confidence: 99%

“…Twenty‐two studies investigated the association of sarcopenia and falls, of which 10 studies (45%) reported higher risks of falls among sarcopenic individuals compared with non‐sarcopenic individuals . Non‐significant associations between sarcopenia and falls were found in the remaining 12 studies …”

Section: Resultsmentioning

confidence: 99%

“…. Other definitions are based on both low muscle mass and low muscle strength/physical performance: European Working Group on Sarcopenia in Older People (EWGSOP), Asian Working Group for Sarcopenia (AWGS), Foundation for the National Institutes of Health (FNIH), International Working Group on Sarcopenia (IWGS), Society for Sarcopenia, Cachexia, and Wasting Disorders (SCWD), and ESPEN Special Interest Group on ‘cachexia‐anorexia in chronic wasting diseases’ and ‘nutrition in geriatrics’ . In cases where studies applied multiple sarcopenia definitions, results based on the EWGSOP definition were prioritized over the Baumgartner definition and other definitions …”

Section: Methodsmentioning

confidence: 99%

See 3 more Smart Citations

Sarcopenia and its association with falls and fractures in older adults: A systematic review and meta‐analysis

Yeung

Reijnierse

Pham

et al. 2019

J cachexia sarcopenia muscle

616

463

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Sarcopenia is a potentially modifiable risk factor for falls and fractures in older adults, but the strength of the association between sarcopenia, falls, and fractures is unclear. This study aims to systematically assess the literature and perform a meta‐analysis of the association between sarcopenia with falls and fractures among older adults. A literature search was performed using MEDLINE, EMBASE, Cochrane, and CINAHL from inception to May 2018. Inclusion criteria were the following: published in English, mean/median age ≥ 65 years, sarcopenia diagnosis (based on definitions used by the original studies' authors), falls and/or fractures outcomes, and any study population. Pooled analyses were conducted of the associations of sarcopenia with falls and fractures, expressed in odds ratios (OR) and 95% confidence intervals (CIs). Subgroup analyses were performed by study design, population, sex, sarcopenia definition, continent, and study quality. Heterogeneity was assessed using the I 2 statistics. The search identified 2771 studies. Thirty‐six studies (52 838 individuals, 48.8% females, and mean age of the study populations ranging from 65.0 to 86.7 years) were included in the systematic review. Four studies reported on both falls and fractures. Ten out of 22 studies reported a significantly higher risk of falls in sarcopenic compared with non‐sarcopenic individuals; 11 out of 19 studies showed a significant positive association with fractures. Thirty‐three studies (45 926 individuals) were included in the meta‐analysis. Sarcopenic individuals had a significant higher risk of falls (cross‐sectional studies: OR 1.60; 95% CI 1.37–1.86, P < 0.001, I 2 = 34%; prospective studies: OR 1.89; 95% CI 1.33–2.68, P < 0.001, I 2 = 37%) and fractures (cross‐sectional studies: OR 1.84; 95% CI 1.30–2.62, P = 0.001, I 2 = 91%; prospective studies: OR 1.71; 95% CI 1.44–2.03, P = 0.011, I 2 = 0%) compared with non‐sarcopenic individuals. This was independent of study design, population, sex, sarcopenia definition, continent, and study quality. The positive association between sarcopenia with falls and fractures in older adults strengthens the need to invest in sarcopenia prevention and interventions to evaluate its effect on falls and fractures.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

See 2 more Smart Citations

Sarcopenia and its association with falls and fractures in older adults: A systematic review and meta‐analysis

Yeung

Reijnierse

Pham

et al. 2019

J cachexia sarcopenia muscle

616

463

View full text Add to dashboard Cite

show abstract

“…One important and valuable study, which included 5934 community‐dwelling men written by Cawthon et al ., found that sarcopenia is a risk factor for recurrent falls among older adults dwelling in the community (OR: 2.34; 95% CI: 1.33–4.13) while they did not found that sarcopenia individual is a risk factor that can increase the rate of hip fractures compared with non‐sarcopenia older people (HR: 1.17; 95% CI: 0.71–1.93). Although Yeung showed that there were three studies among nursing home residents in this systematic review and meta‐analysis, the data of the Henwood et al . study (OR: 0.74; 95% CI: 0.34–1.63) were not included in the pooled result.…”

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confidence: 95%

Comment on: “Sarcopenia and its association with falls and fractures in older adults: A systematic review and meta‐analysis” by Yeung et al.

Zhang

Cheng

Dou

et al. 2020

J cachexia sarcopenia muscle

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The authors reply: Letter on: “ Sarcopenia and its association with falls and fracturesin older adults: A systematic review andmeta‐analysis” by Zhang et al.

Yeung

Heymans

Maier

2020

J cachexia sarcopenia muscle

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Thank you for the comments to our recent article "Sarcopenia and its association with falls and fractures in older adults: A systematic review and meta-analysis". 1 Firstly, as mentioned in our article, studies were excluded from the meta-analysis if an odds ratio (OR) could not be calculated because of insufficient data, or confidence intervals were not presented. Therefore, we were not able to include the studies of Cawthon, 2 Schaap, 3 and Henwood, 4 as hazard ratios 2,3 or risk ratios 4 were reported. These measures are not interchangeable with ORs 5,6 but can be converted if information about the baseline risk is available. 7 We agree that the above-mentioned studies are valuable; therefore, we contacted the authors to obtain the data needed to compute ORs. Two authors of the three studies responded, which allowed us to include those studies in the meta-analysis. 2,3 Both were prospective studies examining the association between sarcopenia with falls and fractures. ORs reported in our original article 1 did not change significantly after inclusion Figure 1 Forest plot of odds ratio for falls in sarcopenic individuals vs. non-sarcopenic individuals

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Consequences of sarcopenia among nursing home residents at long-term follow-up

Cited by 34 publications

References 30 publications

Sarcopenia and its association with falls and fractures in older adults: A systematic review and meta‐analysis

Sarcopenia and its association with falls and fractures in older adults: A systematic review and meta‐analysis

Comment on: “Sarcopenia and its association with falls and fractures in older adults: A systematic review and meta‐analysis” by Yeung et al.

The authors reply: Letter on: “ Sarcopenia and its association with falls and fracturesin older adults: A systematic review andmeta‐analysis” by Zhang et al.

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