Consequences of Preservative Uptake and Release by Contact Lenses

Morris, Carol A.; Maltseva, Inna; Rogers, Victoria A.; Ni, Jian; Khong, Kathleen; Derringer, Charles B; George, Melanie; Luk, Andrew S

doi:10.1097/icl.0000000000000480

Cited by 12 publications

(12 citation statements)

References 22 publications

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“…Contact lens materials can adsorb components from care solutions, including disinfectants, surfactants, wetting agents and other constituents designed to disinfect, clean and wet contact lenses, and release them onto the corneal surface during lens wear, potentially affecting the clinical performance of the contact lens on the eye [337][338][339]. The kinetics of uptake and release of PHMB or PQ1 from various contact lenses have been studied, initially with the pure compounds and then after soaking in MPDS containing these compounds [340]. Lenses soaked in MPDS were tested for antibacterial activity.…”

Section: Contact Lens Uptake and Release Of Care Solution Componentsmentioning

confidence: 99%

BCLA CLEAR - Contact lens wettability, cleaning, disinfection and interactions with tears

Willcox

Keir

Maseedupally

et al. 2021

Contact Lens and Anterior Eye

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Contact lens materials have undergone significant changes over the past 20 years, particularly with respect to the introduction of silicone hydrogel materials. Whilst this development addressed hypoxic issues, other important areas relating to contact lens success, notably comfort, require further research.Contact lens wettability remains a crucially important part of biocompatibility. Contact lenses can be made more wettable by incorporation of surfactants into blister packs, internal wetting agents, surface treatments or care solutions. However, there remains no clear association between contact lens wettability and comfort, making it challenging to determine the potential for these approaches to be of significant clinical benefit. Most contact lenses are used on a daily wear, reusable basis, which requires them to be disinfected when not worn. The ideal disinfecting solution would also improve comfort during wear. However, balancing these requirements with other factors, including biocompatibility, remains a challenge. Soft lens materials invariably take up and subsequently release certain components of disinfecting solutions onto the ocular surface. This may affect tear film stability and the normal ocular microbiome, and further research is needed in this area to determine whether this has any affect on comfort. Finally, contact lens materials sorb components of the tear film, and these interactions are complex and may change the biochemistry of the tear film, which in turn may affect their comfort.In conclusion, the interaction between lens materials, tear film and disinfection solution plays an important role in the biocompatibility of lenses. However, the exact role and whether this can be altered to improve biocompatibility and comfort during wear remains debatable. This report summarises the best available evidence to examine this complex relationship and the opportunities for practitioners to enhance in-eye comfort of contemporary lenses, along with providing suggestions for areas of study that may provide further information on this topic.

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Section: Contact Lens Uptake and Release Of Care Solution Componentsmentioning

confidence: 99%

BCLA CLEAR - Contact lens wettability, cleaning, disinfection and interactions with tears

Willcox

Keir

Maseedupally

et al. 2021

Contact Lens and Anterior Eye

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“…This disinfection provides an opportunity to kill any microbes, including coronavirus, that may be contaminating the lenses after wear and prior to re-wear. Contact lenses soaked in multipurpose disinfecting solutions can take up excipients and impart antibacterial activity [10,11].…”

Section: Introductionmentioning

confidence: 99%

Antiviral effect of multipurpose contact lens disinfecting solutions against coronavirus

Yasir

Vijay

Willcox

2022

Contact Lens and Anterior Eye

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To evaluate the antiviral potential of five multipurpose disinfecting solutions against coronavirus (mouse hepatitis virus, a surrogate for SARS-CoV-2 human corona virus). Methods: Test solutions (Biotrue, renu Advanced [Bausch and Lomb], ACUVUE RevitaLens [Johnson and Johnson Vision], cleadew [Ophtecs corp.] or AOSept Plus [Alcon]) were mixed with the coronavirus mouse hepatitis virus at 10 4 plaque forming units (PFU)/mL as the final concentration and incubated at room temperature for the specified disinfection time. Surviving virus from each sample was then quantified by standard plaque forming unit assay and the reduction of PFU for each disinfectant was compared to the phosphate buffer saline (PBS) treated negative control. A regimen test was also conducted using Biotrue. Results: The three multipurpose disinfecting solutions Biotrue (containing PHMB and polyquaternium-1), renu Advanced (PHMB, polyquaternium-1 and alexidine) and ACUVUE RevitaLens (polyquaternium-1 and alexidine) did not kill the coronavirus at the manufacturers recommended disinfection time in the stand alone test. After treatment, the virus's titer (3.8 ± 0.2 log 10 for Biotrue, 3.7 ± 0.1 log 10 for renu and 3.7 ± 0.2 log 10 for Revi-taLens) was similar to the negative control (3.7 ± 0.1 log 10 ; p ≥ 0.996). AOSept Plus (hydrogen peroxide) and cleadew (povidone iodine) significantly (p < 0.001) reduced the numbers of coronaviruses to below the detection limit (i.e. killed 3.7 ± 0.1 log 10 viruses compared to control). However, there was a significant reduction (p = 0.028) in numbers of coronaviruses attached to lenses when using the regimen test with Biotrue. Conclusions: This study shows that oxidative contact lens disinfecting solutions (i.e. those containing povidoneiodine or hydrogen peroxide) provide superior antiviral activity against a coronavirus surrogate of SARS-CoV-2, unless the full regimen test (rub, rinse, disinfect) is used.

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“…As mentioned before a considerable volume of aggressive ingredients is stored in the polymeric material of contact lenses after disinfection [18]. As contact lens solutions are known to have adverse effects on the patient's eye [19][20][21][22][23][24][25][26], a reduced concentration will decrease the patient's risk of epithelial damage.…”

Section: Discussionmentioning

confidence: 99%

“…Another study [17] found a 12-fold increase of P. aeruginosa uptake into the corneal epithelium of rabbits following the wear of multipurpose solution-soaked lenses. Uptake of preservatives into different types of polymeric lens materials was demonstrated [18], as well as the release of disinfectant, occurring after reinsertion of the lens to the ocular surface.…”

Section: Introductionmentioning

confidence: 99%

Enhancement of Contact Lens Disinfection by Combining Disinfectant with Visible Light Irradiation

Hoenes

Spellerberg

Heßling

2020

IJERPH

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Multiple use contact lenses have to be disinfected overnight to reduce the risk of infections. However, several studies demonstrated that not only microorganisms are affected by the disinfectants, but also ocular epithelial cells, which come into contact via residuals at reinsertion of the lens. Visible light has been demonstrated to achieve an inactivation effect on several bacterial and fungal species. Combinations with other disinfection methods often showed better results compared to separately applied methods. We therefore investigated contact lens disinfection solutions combined with 405 nm irradiation, with the intention to reduce the disinfectant concentration of ReNu Multiplus, OptiFree Express or AOSept while maintaining adequate disinfection results due to combination benefits. Pseudomonads, staphylococci and E. coli were studied with disk diffusion assay, colony forming unit (cfu) determination and growth delay. A log reduction of 4.49 was achieved for P. fluorescens in 2 h for 40% ReNu Multiplus combined with an irradiation intensity of 20 mW/cm2 at 405 nm. For AOSept the combination effect was so strong that 5% of AOSept in combination with light exhibited the same result as 100% AOSept alone. Combination of disinfectants with visible violet light is therefore considered a promising approach, as a reduction of potentially toxic ingredients can be achieved.

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Consequences of Preservative Uptake and Release by Contact Lenses

Cited by 12 publications

References 22 publications

BCLA CLEAR - Contact lens wettability, cleaning, disinfection and interactions with tears

BCLA CLEAR - Contact lens wettability, cleaning, disinfection and interactions with tears

Antiviral effect of multipurpose contact lens disinfecting solutions against coronavirus

Enhancement of Contact Lens Disinfection by Combining Disinfectant with Visible Light Irradiation

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