Consequences of major bleeding in hospitalized patients with non-ST segment elevation acute coronary syndromes receiving injectable anticoagulants

Happe, Laura E.; Rao, Sunil V.; Horblyuk, Ruslan; Franklin, Meg; Lunacsek, Orsolya; Menditto, Laura

doi:10.1185/03007990802649133

Cited by 18 publications

(10 citation statements)

References 22 publications

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“…This study also confirms not only that bleeding is associ-219 ated with a doubling of hospital stay, which is consistent with 220 published studies, but also that patients who experienced 221 major bleeding were at significantly increased risk of re-222 admission to hospital [1,24,26,27]. Indicating that in addition …”

supporting

confidence: 91%

“…Bleeding is a common complication of PCI that not only has 22 an immediate impact on the well-being of the patient and the 23 need for additional resources in hospital, but also contributes 24 to poor long-term outcomes including increased risk of death 25 [1][2][3][4][5][6][7][8]. The risk of bleeding is likely to depend on the indi- 26 vidual risk profile of the patient being treated, the Among patients who did not experience an OHCA, females 132 were at higher risk of bleeding than males.…”

mentioning

confidence: 99%

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Incidence, Predictors and Outcomes of Major Bleeding in Patients Following Percutaneous Coronary Interventions in Australia

Wlodarczyk¹,

Ajani

Kemp³

et al. 2016

Heart, Lung and Circulation

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supporting

confidence: 91%

mentioning

confidence: 99%

Incidence, Predictors and Outcomes of Major Bleeding in Patients Following Percutaneous Coronary Interventions in Australia

Wlodarczyk¹,

Ajani

Kemp³

et al. 2016

Heart, Lung and Circulation

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“…Although heparin abrogates catheter thrombosis, its use in conjunction with potent antiplatelet drugs can lead to serious bleeding complications [3]. This is problematic because there is mounting evidence that bleeding in ACS patients is associated with adverse outcomes, including increased mortality [4][5][6][7]. To reduce the risk of bleeding, attention has focused on anticoagulants that are safer than heparin in the ACS setting.…”

Section: Introductionmentioning

confidence: 99%

Corn trypsin inhibitor coating attenuates the prothrombotic properties of catheters in vitro and in vivo

et al. 2012

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“…Severe bleeding was defined as the presence of selected bleeding conditions during the index hospitalization (Table E3; available as electronic supplementary material). 32 In the case of heparin-induced thrombocytopenia (HIT), it was defined as a positive PF4/ heparin ELISA test. We also used the Canadian Classification of Diagnostic, Therapeutic, and Surgical Procedures before 2006 and the Canadian Classification of Health Interventions after 2006 to consider the following interventions associated with thrombocytopenia if they were performed or started prior to the onset of thrombocytopenia: hemodialysis, extracorporeal circulation, coronary bypass grafting, intra-aortic balloon pump placement, splenectomy, and blood transfusion (Table E2; available as electronic supplementary material).…”

Section: Data Collectionmentioning

confidence: 99%

Thrombocytopenia in the critically ill: prevalence, incidence, risk factors, and clinical outcomes

Williamson

Lesur

Tétrault

et al. 2013

Can J Anesth/J Can Anesth

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Purpose The aim of this cohort study was to describe the prevalence, incidence, and risk factors for thrombocytopenia in the intensive care unit (ICU) and to evaluate the impact of thrombocytopenia on mortality with further comparisons amongst major diagnostic categories. Methods Patients admitted to the ICU from 1997-2011 for cardiac, medical, surgical, and trauma conditions were included. The presence of a platelet count\ 100 9 10 9 ÁL -1 on admission day or its appearance during ICU stay were considered as prevalent and incident thrombocytopenia, respectively. Risk factors for thrombocytopenia and the influence of thrombocytopenia on mortality were also analyzed. Results This study included 20,696 patients. Prevalent and incident thrombocytopenia occurred in 13.3% and 7.8% of patients, respectively, with associated mortality rates of 14.3% and 24.7%, respectively, compared with 10.2% in the group with normal platelet count (P \ 0.001). After adjustments, thrombocytopenia remained associated with an increased risk of mortality (odds ratio 1.25; 95% confidence interval 1.20 to 1.31; P \ 0.001). The greatest impact of thrombocytopenia on mortality was observed in the cancer, respiratory, digestive, genitourinary, and infectious diagnostic categories. Independent risk factors included age, female sex, admission platelet counts and hemoglobin, mechanical ventilation, days of hospitalization prior to ICU admission, liver cirrhosis, hypersplenism, coronary bypass grafting, intra-aortic balloon pump placement, acute hepatitis, septic shock, and pulmonary embolism or deep vein thrombosis. Conclusions Thrombocytopenia in the ICU is associated with an independent risk of mortality that varies greatly depending on diagnostic admission category.Electronic supplementary material The online version of this article

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Consequences of major bleeding in hospitalized patients with non-ST segment elevation acute coronary syndromes receiving injectable anticoagulants

Cited by 18 publications

References 22 publications

Incidence, Predictors and Outcomes of Major Bleeding in Patients Following Percutaneous Coronary Interventions in Australia

Incidence, Predictors and Outcomes of Major Bleeding in Patients Following Percutaneous Coronary Interventions in Australia

Corn trypsin inhibitor coating attenuates the prothrombotic properties of catheters in vitro and in vivo

Thrombocytopenia in the critically ill: prevalence, incidence, risk factors, and clinical outcomes

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