Consequences of low plasma histidine in chronic kidney disease patients: associations with inflammation, oxidative stress, and mortality

Watanabe, Makoto; Suliman, Mohamed E.; Qureshi, Abdul Rashid; García–López, Elvia; Bárány, Peter; Heimbürger, Olof; Stenvinkel, Peter; Lindholm, Bengt

doi:10.1093/ajcn/87.6.1860

Cited by 234 publications

(156 citation statements)

References 38 publications

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“…These supportive effects are thought to be associated with improved bacterial flora, low antigenicity, and improved nutritional status [20,21]. Meanwhile, some reports have suggested that amino acids such as glutamine, glycine, and histamine have an anti-inflammatory effect on animal experimental and human chronic inflammatory disease [22][23][24][25][26]. Therefore, the abundant amino acids within ED might directly alleviate pancreatic inflammation and lead to pain relief.…”

Section: Discussionmentioning

confidence: 99%

Medical Management of Chronic Pancreatitis: What Can Physicians Do?

Lee¹

2017

Korean J Pancreas Biliary Tract

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Background & Aims. Chronic pancreatitis (CP) is often associated with abdominal pain, which impairs quality of life. The aim of this prospective study was to clarify whether the use of a low-fat elemental diet (ED) is beneficial for managing pain in patients with CP. Methods. Seventeen CP patients with pain despite fat-restricted dietary and conventional medical treatments were enrolled in this prospective study. These patients received low-fat ED therapy in addition to restricting fat intake for 8 weeks. The change of pain severity was examined by interviewing the patient and status of analgesic use. Results. Mean serum levels of amylase and lipase at 8 weeks after the beginning of low-fat ED therapy decreased compared to those before the therapy. At 8 weeks, pain alleviation after low-fat ED therapy was reported in 15 out of 17 patients (88%). Of these 15 patients, 10 patients reported complete pain disappearance. One of 3 patients with severe or moderate pain requiring analgesic was relieved of analgesic use after low-fat ED therapy. Conclusion. Low-fat ED therapy is useful as means of pain control in CP. The therapy is recommended in outpatients with CP who present with pain despite conventional dietary and medical treatments.

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Section: Discussionmentioning

confidence: 99%

Medical Management of Chronic Pancreatitis: What Can Physicians Do?

Lee¹

2017

Korean J Pancreas Biliary Tract

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“…The reduction of histidine, phenylalanine, and tyrosine, may reduce neurotransmitter levels such as histamine and dopamine and contribute to endocrine disorders [27]. The etiology of type II ketosis is partly or completely attributed to a deficiency in insulin, a lack of insulin receptors, or poor insulin receptor sensitivity, which may result in poor glucose utilization, high blood glucose levels, and disorders in lipid and amino acid metabolism [28]. Type II ketosis, which usually occurs in cows during the dry period, is similar to noninsulin-dependent diabetes (type II diabetes).…”

Section: Discussionmentioning

confidence: 99%

1H NMR-based Plasma Metabolic Profiling of Dairy Cows with Type I and Type II Ketosis

Li¹

2015

Pharm Anal Acta

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This study identified differences in plasma metabolites among three groups of dairy cows: type I ketotic (K1), type II ketotic (K2), and healthy control cows (C). 50 cows with two or three parities were selected at 7-28 days postpartum. Cows were classified as type I ketotic (K1, 20 cows), type II ketotic (K2, 20 cows), or healthy control cows (C, 10 cows). Plasma metabolomic profiles were analyzed by 1H-nuclear magnetic resonance technology ( 1 H NMR). The data were processed by principal component analysis and orthogonal partial least-squares discriminant analysis (OPLS-DA). Results-The results revealed that OPLS-DA was more effective at distinguishing amongst the three groups. Additionally, there were seven different metabolites between K2 and C, 19 different metabolites between K1 and C, and 24 different metabolites between K1 and K2. Therefore, the combination of 1 H-NMR and multivariate statistical analyses can effectively distinguish the differential metabolites among the K1, K2, and C groups, thereby providing important information on the pathogenesis, early diagnosis, and prevention of type I and type II ketosis in dairy cows. H NMR-based AbstractThis study identified differences in plasma metabolites among three groups of dairy cows: type I ketotic (K1), type II ketotic (K2), and healthy control cows (C). 50 cows with two or three parities were selected at 7-28 days postpartum. Cows were classified as type I ketotic (K1, 20 cows), type II ketotic (K2, 20 cows), or healthy control cows (C, 10 cows). Plasma metabolomic profiles were analyzed by 1H-nuclear magnetic resonance technology ( 1 H NMR). The data were processed by principal component analysis and orthogonal partial least-squares discriminant analysis (OPLS-DA). Results-The results revealed that OPLS-DA was more effective at distinguishing amongst the three groups. Additionally, there were seven different metabolites between K2 and C, 19 different metabolites between K1 and C, and 24 different metabolites between K1 and K2. Therefore, the combination of 1 H-NMR and multivariate statistical analyses can effectively distinguish the differential metabolites among the K1, K2, and C groups, thereby providing important information on the pathogenesis, early diagnosis, and prevention of type I and type II ketosis in dairy cows.

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“…[7][8][9] Finally, proteinenergy wasting (malnutrition or cachexia) is a strong independent predictor of an adverse outcome. 10 As excess protein intake in chronic kidney disease (CKD) leads to the accumulation of waste nitrogen, total intake of AAs must be carefully regulated. In theory, diets containing low levels of NEAA and supplemented with nitrogen-free EAA analogs (keto acids) would be ideal and may serve to improve the metabolic profile as well as to decrease oxidative stress 10 and/or muscle catabolism, 11 thus improve outcome.…”

Section: Introductionmentioning

confidence: 99%

“…10 As excess protein intake in chronic kidney disease (CKD) leads to the accumulation of waste nitrogen, total intake of AAs must be carefully regulated. In theory, diets containing low levels of NEAA and supplemented with nitrogen-free EAA analogs (keto acids) would be ideal and may serve to improve the metabolic profile as well as to decrease oxidative stress 10 and/or muscle catabolism, 11 thus improve outcome. 10 In addition, keto acids are of therapeutic value in uremia by supplying EAA for protein synthesis at the expense of endogenous nonessential nitrogen, thus release the kidney burden.…”

Section: Introductionmentioning

confidence: 99%

“…In theory, diets containing low levels of NEAA and supplemented with nitrogen-free EAA analogs (keto acids) would be ideal and may serve to improve the metabolic profile as well as to decrease oxidative stress 10 and/or muscle catabolism, 11 thus improve outcome. 10 In addition, keto acids are of therapeutic value in uremia by supplying EAA for protein synthesis at the expense of endogenous nonessential nitrogen, thus release the kidney burden. 12 It is now unknown whether dietary intervention, which is low in protein and supplemented with keto acids, would do favor for AA metabolism in PD patients.…”

Section: Introductionmentioning

confidence: 99%

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Improved plasma amino acids pattern following 12 months of supplemented low-protein diet in peritoneal dialysis patients

et al. 2010

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Background: Decreased plasma essential amino acid (EAA) levels, increased nonessential amino acid (NEAA) levels, and low EAA to NEAA ratio (E/NEAA) are common in peritoneal dialysis (PD) patients and may impact uremic complications. In the present study, we investigate the impact of keto acids-supplemented lowprotein (sLP) diet on plasma amino acids (AAs) patterns in stable PD patients. Methods: This is a supplemental analysis of a previously published prospective and randomized trial. Thirty-nine PD patients selected from the original population were divided to receive either low (LP: 0.6-0.8 g/kg ideal body weight [IBW]/d, n = 13), keto acids-supplemented low-(sLP: 0.6-0.8 g/kg IBW/d + 0.12 g/kg IBW/d of keto acids, n = 12), or high-(HP: 1.0-1.2 g/kg IBW/d, n = 14) protein diets and followed for 1 year. Plasma AA patterns were assessed at baseline and 12 months using high-performance liquid chromatography. Results: Whereas there were no significant differences between the three groups at baseline, following 12 months, the E/NEAA had increased significantly in group sLP (0.58 ± 0.16 to 0.83 ± 0.20, p < 0.05), but was not different in either LP (0.62 ± 0.20 to 0.72 ± 0.13, p = ns) or HP (0.66 ± 0.14 to 0.74 ± 0.12, p = ns) group. This change in E/NEAA in group sLP was due to a significant decrease in NEAA concomitantly with maintained EAA levels, whereas in the other two groups, neither EAA nor NEAA changed significantly. Conclusions: A low-protein diet supplemented with keto acids significantly improved the pattern of plasma AA in prevalent PD patients.

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Consequences of low plasma histidine in chronic kidney disease patients: associations with inflammation, oxidative stress, and mortality

Abstract: Low plasma concentrations of histidine are associated with protein-energy wasting, inflammation, oxidative stress, and greater mortality in CKD patients.

Cited by 234 publications

References 38 publications

Medical Management of Chronic Pancreatitis: What Can Physicians Do?

Medical Management of Chronic Pancreatitis: What Can Physicians Do?

1H NMR-based Plasma Metabolic Profiling of Dairy Cows with Type I and Type II Ketosis

Improved plasma amino acids pattern following 12 months of supplemented low-protein diet in peritoneal dialysis patients

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