Consequences of Intrauterine Enrofloxacin Infusion on Mare Endometrium

Rodriguez, Jacobo S.; Han, Sushan; Nielsen, Samuel W.; Pearson, Lisa K.; Tibary, Ahmed

doi:10.1016/j.jevs.2011.08.003

Cited by 15 publications

(16 citation statements)

References 18 publications

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“…Zooepidemicus, the degree of endometrosis did not change during the 2-year period of the observation (Hoffmann et al 2009b). Recently it was shown that intrauterine enrofloxacin infusion in mares induced severe acute uterine mucosal necrosis, inflammation, and a significant increase in endometrial fibrosis (Rodriguez et al 2012).…”

Section: Pathogenesismentioning

confidence: 88%

Endometrosis – significance for horse reproduction, pathogenesis, diagnosis, and proposed therapeutic methods

Buczkowska¹,

Kozdrowski²,

Nowak³

et al. 2014

Polish Journal of Veterinary Sciences

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Equine endometrosis is a multifactorial disease considered to be a one of the most important causes of equine infertility, especially in older mares. This article reviews the current knowledge of equine endometrosis: pathogenesis, diagnosis, and optional treatment. Also describes the histomorphological and immunohistochemical characterization of endometrosis as well as potential etiological factors which may influence disease progression. Unfortunately, the etiology and pathogenesis of endometrosis still remains unclear, and consequently no effective treatment has been proposed so far. Therefore future studies are needed for explanation of this disease.

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Section: Pathogenesismentioning

confidence: 88%

Endometrosis – significance for horse reproduction, pathogenesis, diagnosis, and proposed therapeutic methods

Buczkowska¹,

Kozdrowski²,

Nowak³

et al. 2014

Polish Journal of Veterinary Sciences

View full text Add to dashboard Cite

show abstract

“…In a recent study, bacterial isolates from cases of endometritis have been shown to be extremely sensitive to enrofloxacin [14]. However, daily intrauterine infusion of a commercial preparation of enrofloxacin was shown to be very harmful to the uterus and produced irreversible damage to the endometrium [2].…”

Section: Discussionmentioning

confidence: 99%

“…However, in a more recent study, daily intrauterine administration of the same dose of an enrofloxacin commercial preparation (Baytril-100, Bayer HealthCare, Animal Health, Shawnee Mission, KS) during estrus resulted in a severe, acute, ulcerative, hemorrhagic endometritis [2]. Treated mares showed deterioration of the endometrial biopsy grade and development of intrauterine adhesions and fibrosis [2]. The authors speculated that the acute changes and fibrosis may be due to the caustic effect of the pH (10.4) of the enrofloxacin preparation or the excipients used.…”

Section: Introductionmentioning

confidence: 99%

“…Endometritis is considered the most common cause of infertility and early embryonic loss (<35 days) in mares [1][2][3]. Bacterial endometritis may be caused by a variety of Gram-positive and Gram-negative bacteria [3][4][5].…”

Section: Introductionmentioning

confidence: 99%

“…A study showed that a single intrauterine infusion at a dose of 2.5 mg/kg produced statistically nonsignificant histologic inflammatory changes [10]. However, in a more recent study, daily intrauterine administration of the same dose of an enrofloxacin commercial preparation (Baytril-100, Bayer HealthCare, Animal Health, Shawnee Mission, KS) during estrus resulted in a severe, acute, ulcerative, hemorrhagic endometritis [2]. Treated mares showed deterioration of the endometrial biopsy grade and development of intrauterine adhesions and fibrosis [2].…”

Section: Introductionmentioning

confidence: 99%

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