Consequences of Induction of Foreign Compound-Metabolizing Enzymes in Insects

Yu, Simon J.

doi:10.1007/978-1-4613-1865-1_4

Cited by 43 publications

(29 citation statements)

References 77 publications

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“…PhenobarbitaI was also found to stimulate microsomal juvenile hormone oxidase activity in house flies (Yu and Terriere, 1978). Since allelochemicals were shown to stimulate various microsomal monooxygenase activities in insects (Yu, 1986), it is likely that certain allelochemicals also enhance the juvenile hormone oxidase activity in insects. If so, the physiological effects of allelochemicals on insect development will be difficult to predict because these compounds may interfere with normal metabolism of both ecdysone and juvenile hormone.…”

Section: Discussionmentioning

confidence: 98%

Allelochemical stimulation of ecdysone 20‐monooxygenase in fall armyworm larvae

1995

Arch Insect Biochem Physiol

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The influence of dietary allelochemical on ecdysone 20-monooxygenase activity was studied in the fall armyworm, Spodoptera frugiperda (J.E. Smith). Feeding the indoles (indole-3-carbinol, indole-3-acetonitrile), flavonoids (flavone, P-naphthoflavone), rnonoterpenes (menthol, rnenthone, peppermint oil), and a coumarin (xanthotoxin) to the larvae stimulated midgut microsomal ecdysone 20-monooxygenase activity from 28 to 200% as compared with the controls. P-Naphthoflavone was the most potent inducer among those tested. Phenobarbital, a well-known cytochrome P450 inducer, also caused a 2-fold increase in the microsomal ecdysone 20-monooxygenase activity. Ecdysone 20-rnonooxygenase activity was 2.7-fold higher in the microsomal fraction than in the mitochondria1 fraction isolated from larval midguts. Microsomal ecdysone 20-rnonooxygenase activity was highest in the fat body, followed by the midgut and Malpighian tubules. Tissue localization and enzyme inducibility were different between ecdysone 20-monooxygenase and xenobiotic-metabolizing cytochrome P450 monooxygenases, including aldrin epoxidase, biphenyl hydroxylase, methoxyresorufin 0-demethylase, 7-ethoxycoumarin 0-deethylase, pchloro-N-methylaniline N-demethylase, and phorate sulfoxidase in fall armyworm larvae. 0 1995 Why-Liss, Inc.

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Section: Discussionmentioning

confidence: 98%

Allelochemical stimulation of ecdysone 20‐monooxygenase in fall armyworm larvae

1995

Arch Insect Biochem Physiol

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“…Many insects are known to increase their ability to detoxify xenobiotics after a period of feeding on them, due to production of higher levels of detoxification enzymes (e.g., Yu, 1986;Lindroth, 1991). Induction of relatively high levels of such enzymes can occur within one or two days (e.g., Wadleigh & Yu, 1988).…”

Section: A Multiplicity Of Mechanismsmentioning

confidence: 99%

Induced food preferences in caterpillars: the need to identify mechanisms

Bernays

Weiss

1996

Entomologia Exp Applicata

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This review discusses the ambiguity of results obtained from dual-choice feeding tests, especially in relation to the study of effects of experience. Induced preference experiments done this way can be caused by up to nine potential changes in caterpillar behavior. In addition different physiological mechanisms that could lead to the process of induced preference are discussed. These include habituation to deterrents, the increased ability to process xenobiotics, the acquisition of specific positive responses, sensitization, and associative learning. These different processes might relate to function in different ways so that distinguishing them is important to progress in understanding the phenomenon. Suggestions for experimental designs that provide details on processes involved are indicated.

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“…To date, at least 27 species of insects and mites have been shown to have inducible detoxification systems, including Lepidoptera, Diptera, Orthoptera, Heteroptera, Coleoptera, and Acarina. Among the allelochemicals tested, monoterpenes (e.g., a-pinene), indoles (e.g., indole-3-carbinol), flavonoids (e.g., flavone), coumarins (e.g., xanthotoxin), and glucosinolates (e.g., sinigrin) were all inducers of these detoxifying enzymes in the fall armyworm, suggesting that induction involves a common regulatory mechanism [2].…”

Section: Introductionmentioning

confidence: 99%

Induction of detoxification enzymes in phytophagous insects: Role of insecticide synergists, larval age, and species

Yu¹,

Hsu²

1993

Arch Insect Biochem Physiol

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Five insecticide synergists, all of which were either methylenedioxyphenyl compounds or analogs, were compared as to their effect on cytochrome P450 monooxygenase induction caused by an allelochemical in fall armyworm larvae. Feeding the synergists (piperonyl butoxide, safrole, isosafrole, MCK 264, and myristicin) individually to the larvae caused decreases in the microsomal aldrin epoxidase activities ranging from 38% to 74% when compared with controls. Feeding indole-3-carbinol resulted in a 4-fold increase in the rnicrosomal epoxidase activity. However, cotreatment of any of the synergists and the inducer completely eliminated the induction. Sixth instar larvae were more inducible than second instar larvae with respect to microsomal epoxidase and glutathione transferase in the fall armyworm. Enzyme inducibility varied widely among the seven phytophagous Lepidoptera examined. When indole-3-carbinol was used as an inducer of microsomal epoxidase, the extent of inducibility of the enzyme was fall armyworm > velvetbean caterpillar > corn earworm > beet armyworm > tobacco budworm > cabbage looper > diamondback moth. When indole-3-acetonitrile was used as an inducer, the inducibility of glutathione transferase was fall armyworm > beet armyworm > corn earworm > cabbage looper > velvetbean caterpillar > tobacco budworm > diamondback moth. lnducibilityoffive microsomal oxidase systems also varied considerably in the corn earworm, indicating the multiplicity of cytochrome P450 in this species. Microsomal epoxidase and glutathione transferase were induced by cruciferous host plants such as cabbage and their allelochemicals in diamondback moth larvae. o 1993 WiIey-Liss, Inr

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Consequences of Induction of Foreign Compound-Metabolizing Enzymes in Insects

Cited by 43 publications

References 77 publications

Allelochemical stimulation of ecdysone 20‐monooxygenase in fall armyworm larvae

Allelochemical stimulation of ecdysone 20‐monooxygenase in fall armyworm larvae

Induced food preferences in caterpillars: the need to identify mechanisms

Induction of detoxification enzymes in phytophagous insects: Role of insecticide synergists, larval age, and species

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