Consequences of frequent nocturnal gastro‐oesophageal reflux disease among employed adults: symptom severity, quality of life and work productivity

Dubois, Robert W.; Aguilar, Daniel; Fass, Ronnie; Orr, William C.; Elfant, Adam B.; Dean, Bonnie B.; Harper, Anne; Yu, Hsing Ting; Melmed, Gil Y.; Lynn, Richard B.; Singh, Abhijeet; Tedeschi, Michèle

doi:10.1111/j.1365-2036.2006.03189.x

Cited by 85 publications

(104 citation statements)

References 19 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…In addition, sleep difficulty was reported to be associated with increased health care utilization, impairment of daily activity, and loss of work productivity. Similar results have been published elsewhere [23]. Evidence suggests that reducing nocturnal GERD could provide a significant improvement in sleep, health care costs, and quality of life [24].…”

Section: Introduction Backgroundsupporting

confidence: 76%

Effect on Acid Reflux Symptoms Occurring during Sleep of an Oral Adhering Disc Containing only Food Ingredients

Burgess¹,

Kärcher²

2017

J Gastrointest Dig Syst

View full text Add to dashboard Cite

The aim of this double-blinded, randomized, controlled study was to determine if OraCoat XyliMelts, an over the counter, dissolvable, adhering disc used to reduce excessive day time or night time dry mouth by increasing salivation, would also reduce reflux and heartburn symptoms occurring during sleep among subjects suffering from both GERD and xerostomia. Subjects submitted 14 days of baseline data by answering questions and were then randomized into one of two groups: one receiving a dry mouth gel (control) and a second receiving a disc (product of interest). Neither the identities of the two products nor the manufacturers of the products was revealed to subjects. Answers to the same set of questions were then collected for an additional 14 days as the supplied products were used. The accumulated data were evaluated for pre-post treatment changes within and between groups. Variables included reported heartburn, reflux, reflux taste, hoarseness, dry mouth, and antacid use. The results showed a significant decrease in the severity of the above symptoms of GERD with both disc and gel use, although improvement was greatest for those using the discs. Comparison between the gel and disc groups for most symptoms did not reveal significant differences. For heartburn, subjects using the discs perceived significantly less pain than subjects using the gel. We conclude that the use of certain products intended to reduce dry mouth during sleep, including OraCoat XyliMelts, may be an effective adjunctive remedy for reducing reflux and heartburn symptoms in patients with GERD and xerostomia.

show abstract

Section: Introduction Backgroundsupporting

confidence: 76%

Effect on Acid Reflux Symptoms Occurring during Sleep of an Oral Adhering Disc Containing only Food Ingredients

Burgess¹,

Kärcher²

2017

J Gastrointest Dig Syst

View full text Add to dashboard Cite

show abstract

“…Furthermore, this treatment was more eff ective in reducing the number of work hours missed due to GERD-related sleep disturbances. Th ese results are not unexpected when one considers the connection between repeated lack of sleep during the night and daytime sleepiness ( 9 ), as well as reduced HRQoL and work productivity ( 11 negative impact of nocturnal GERD on HRQoL and work productivity is well recognized ( 7,8,10 ). A recent survey of over 600 GERD patients on various PPI therapies found that the majority of patients continued to experience heartburn, with 83 % experiencing nocturnal symptoms and almost a quarter of these patients reporting severe or very severe nocturnal symptoms ( 32 ).…”

Section: Esophagusmentioning

confidence: 95%

“…Among those reporting GERD symptoms, up to 89 % report nocturnal symptoms ( 1,4 -6 ), resulting in impairment in health-related quality of life (HRQoL) and signifi cantly worse sleep quality ( 7,8 ). Because continued sleep disruption leads to increased daytime sleepiness ( 9 ), nocturnal heartburn can reduce productivity while patients are present at work, as well as reduce function when performing normal daily activities ( 7,8,10,11 ). Th e continued presence of nocturnal heartburn despite routine medical treatment is strongly associated with decreases in HRQoL ( 12 ).…”

mentioning

confidence: 99%

The Effect of Dexlansoprazole MR on Nocturnal Heartburn and GERD-Related Sleep Disturbances in Patients With Symptomatic GERD

Fass

Johnson

Orr

et al. 2011

American Journal of Gastroenterology

View full text Add to dashboard Cite

Approximately 14 -20 % of US adults experience gastroesophageal refl ux disease (GERD) weekly ( 1,2 ), which translates to more than 60 million adults ( 3 ). Among those reporting GERD symptoms, up to 89 % report nocturnal symptoms ( 1,4 -6 ), resulting in impairment in health-related quality of life (HRQoL) and signifi cantly worse sleep quality ( 7,8 ). Because continued sleep disruption leads to increased daytime sleepiness ( 9 ), nocturnal heartburn can reduce productivity while patients are present at work, as well as reduce function when performing normal daily activities ( 7,8,10,11 ). Th e continued presence of nocturnal heartburn despite routine medical treatment is strongly associated with decreases in HRQoL ( 12 ). In addition, the majority of GERD patients participating in a Gallup survey were not completely satisfi ed with their over-the-counter or prescription medication due to persistent nocturnal symptoms ( 6 ).Th e aims of this study were to assess, in patients with symptomatic GERD, the effi cacy and safety of dexlansoprazole MR 30 mg Nocturnal heartburn and related sleep disturbances are common among patients with gastroesophageal refl ux disease (GERD). This study evaluated the effi cacy of dexlansoprazole MR 30 mg in relieving nocturnal heartburn and GERD-related sleep disturbances, improving work productivity, and decreasing nocturnal symptom severity in patients with symptomatic GERD. METHODS:Patients ( N = 305) with frequent, moderate-to-very severe nocturnal heartburn and associated sleep disturbances were randomized 1:1 in a double-blind fashion to receive dexlansoprazole MR or placebo once daily for 4 weeks. The primary end point was the percentage of nights without heartburn. Secondary end points were the percentage of patients with relief of nocturnal heartburn and of GERD-related sleep disturbances over the last 7 days of treatment. At baseline and week 4 / fi nal visit, patients completed questionnaires that assessed sleep quality, work productivity, and the severity and impact of nocturnal GERD symptoms. RESULTS:Dexlansoprazole MR 30 mg ( n = 152) was superior to placebo ( n = 153) in median percentage of nights without heartburn (73.1 vs. 35.7 % , respectively; P < 0.001). Dexlansoprazole MR was signifi cantly better than placebo in percentage of patients with relief of nocturnal heartburn and GERD-related sleep disturbances (47.5 vs. 19.6 % , 69.7 vs. 47.9 % , respectively; P < 0.001), and led to signifi cantly greater improvements in sleep quality and work productivity and decreased nocturnal symptom severity. Adverse events were similar across treatment groups.CONCLUSIONS: In patients with symptomatic GERD, dexlansoprazole MR 30 mg is signifi cantly more effi cacious than placebo in providing relief from nocturnal heartburn, in reducing GERD-related sleep disturbances and the consequent impairments in work productivity, and in improving sleep quality / quality of life.SUPPLEMENTARY MATERIAL is linked to the online version of the paper at

show abstract

“…81 Previous reports have revealed that low quality of life (QOL) was severe in patients with extra-esophageal symptoms. 82,83 The QOL of patients with GERD was associated with psychological factors, including symptoms and mental factors. 84 A recent study with 217 Korean subjects has shown that sleep dysfunction and anxiety were higher and QOL was low in patients with GERD, especially in patients with NERD.…”

Section: Psychological Factorsmentioning

confidence: 99%

Sex and Gender Differences in Gastroesophageal Reflux Disease

Kim

2016

J Neurogastroenterol Motil

122

View full text Add to dashboard Cite

It is important to understand sex and gender-related differences in gastroesophageal reflux disease (GERD) because gender-related biologic factors might lead to better prevention and therapy. Non-erosive reflux disease (NERD) affects more women than men. GERD symptoms are more frequent in patients with NERD than in those with reflux esophagitis. However, men suffer pathologic diseases such as reflux esophagitis, Barrett's esophagus (BE), and esophageal adenocarcinoma (EAC) more frequently than women. The prevalence of reflux esophagitis is significantly increased with age in women, especially after their 50s. The mean age of EAC incidence in women is higher than in men, suggesting a role of estrogen in delaying the onset of BE and EAC. In a chronic rat reflux esophagitis model, nitric oxide was found to be an aggravating factor of esophageal injury in a male-predominant way. In addition, the expression of esophageal occludin, a tight junction protein that plays an important role in the esophageal defense mechanism, was up-regulated in women. This explains the male predominance of reflux esophagitis and delayed incidence of BE or EAC in women. Moreover, the symptoms such as heartburn, regurgitation, and extra-esophageal symptoms have been more frequently reported by women than by men, suggesting that sex and gender play a role in symptom perception. Differential sensitivity with augmented symptoms in women might have diagnostic and therapeutic influence. Furthermore, recent studies have suggested that hormone replacement therapy has a protective effect against esophageal cancer. However, an anti-inflammatory role of estrogen remains compelling, which means further study is necessary in this area.

show abstract

Consequences of frequent nocturnal gastro‐oesophageal reflux disease among employed adults: symptom severity, quality of life and work productivity

Abstract: SUMMARY BackgroundEffects of frequent nocturnal symptoms of gastro-oesophageal reflux disease (GERD-FNS) on health-related quality of life (HRQOL) and work productivity are not well documented.

Cited by 85 publications

References 19 publications

Effect on Acid Reflux Symptoms Occurring during Sleep of an Oral Adhering Disc Containing only Food Ingredients

Effect on Acid Reflux Symptoms Occurring during Sleep of an Oral Adhering Disc Containing only Food Ingredients

The Effect of Dexlansoprazole MR on Nocturnal Heartburn and GERD-Related Sleep Disturbances in Patients With Symptomatic GERD

Sex and Gender Differences in Gastroesophageal Reflux Disease

Contact Info

Product

Resources

About