Consequences of Electron Attachment to Modified Nucleosides Incorporated into DNA

Chomicz-Mańka, Lidia; Wityk, Paweł; Golon, Łukasz; Zdrowowicz, Magdalena; Wiczk, Justyna; Westphal, Kinga; Żyndul, Michał; Makurat, Samanta; Rak, Janusz

doi:10.1007/978-94-007-6169-8_48-1

Cited by 2 publications

(2 citation statements)

References 55 publications

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“…The analysis of the spin multiplicity of the parent anion indicates a quintet electronic structure. The vertical attachment energy (VAE) (also named vertical electron affinity VEA 37 ) is calculated to be positive by 0.39 eV. The relaxed [Mn(II)-(acac) 2 ]* − anion is found lower in energy by 0.05 eV, providing a positive adiabatic electron affinity (AEA) of 0.44 eV (Figure 2b).…”

Section: ■ Results and Discussionmentioning

confidence: 99%

Interaction of Slow Electrons with Thermally Evaporated Manganese(II) Acetylacetonate Complexes

2020

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Complexes of metal acetylacetonate are used as general precursors for the synthesis of metal oxide nanomaterials. In the present work, we study the interaction of low-energy (<10 eV) electrons, produced abundantly as secondary electrons during the bombardment of the substrate by the primary particles, with thermally evaporated manganese(II) acetylacetonate complexes. We found that the acetylacetonate anion ([acac]−) is the major anionic species produced, while the second most abundant is the parent anion [Mn(II)(acac)2]−. This observation differs from those reported from electron attachment to Cu(acac)2, for which [Cu(II)(acac)2]− is the predominant anion [Phys. Chem. Chem. Phys.2018207746]. The experimental data are supported by theory to provide information on the physical-chemistry processes initiated by slow electrons to the organometallic precursor and to interpret the different behavior of Mn(acac)2 compared to Cu(acac)2.

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Section: ■ Results and Discussionmentioning

confidence: 99%

Interaction of Slow Electrons with Thermally Evaporated Manganese(II) Acetylacetonate Complexes

2020

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“…Reactions of radiation-produced electrons with DNA-models have been extensively studied using pulse radiolysis, electron spin resonance (ESR), and theory [3,5,6,7,13,14,15,16,17]. The reactivity of radiation-produced electrons is very dependent on the medium and their energies and these are defined as: (i) Electrons with kinetic energy between 0 and 20 eV are termed low-energy electrons (LEE) [1,2,3,4,5,6,7,8] and are produced in large numbers (~4 × 10 4 electrons per MeV energy deposited) along the tracks of the ionizing radiation [11].…”

Section: Various States Of Radiation-produced Electronsmentioning

confidence: 99%

Reaction of Electrons with DNA: Radiation Damage to Radiosensitization

Kumar

Becker

Adhikary

et al. 2019

IJMS

117

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This review article provides a concise overview of electron involvement in DNA radiation damage. The review begins with the various states of radiation-produced electrons: Secondary electrons (SE), low energy electrons (LEE), electrons at near zero kinetic energy in water (quasi-free electrons, (e−qf)) electrons in the process of solvation in water (presolvated electrons, e−pre), and fully solvated electrons (e−aq). A current summary of the structure of e−aq, and its reactions with DNA-model systems is presented. Theoretical works on reduction potentials of DNA-bases were found to be in agreement with experiments. This review points out the proposed role of LEE-induced frank DNA-strand breaks in ion-beam irradiated DNA. The final section presents radiation-produced electron-mediated site-specific formation of oxidative neutral aminyl radicals from azidonucleosides and the evidence of radiosensitization provided by these aminyl radicals in azidonucleoside-incorporated breast cancer cells.

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Consequences of Electron Attachment to Modified Nucleosides Incorporated into DNA

Cited by 2 publications

References 55 publications

Interaction of Slow Electrons with Thermally Evaporated Manganese(II) Acetylacetonate Complexes

Interaction of Slow Electrons with Thermally Evaporated Manganese(II) Acetylacetonate Complexes

Reaction of Electrons with DNA: Radiation Damage to Radiosensitization

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