Consequences of congenital Zika virus infection

Platt, Derek J.; Miner, Jonathan J.

doi:10.1016/j.coviro.2017.09.005

Cited by 48 publications

(38 citation statements)

References 80 publications

(95 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Currently, this lineage still continues to spread to many countries in which the Aedes mosquito vector is prevalent, which is an efficient vector of ZIKV. Importantly, ZIKV is a flavivirus known to infect key organs such as the brain 14 and reproductive tract 15 , causing Gillian Barré syndrome and microcephaly in new-borns. ZIKV has been shown to be sexually-transmitted and to persist long after ZIKV infection in the testis and other fluids such as semen and urine 16 .…”

Section: Mainmentioning

confidence: 99%

A Zika vaccine based on chimpanzee adenovirus ChAdOx1 elicits lineage-transcending sterile immunity and prevents colonisation of brain and ovaries

López-Camacho

Dowall

Graham

et al. 2019

Preprint

View full text Add to dashboard Cite

Zika virus (ZIKV) continuous spread has affected more than 80 countries and no licenced vaccine is currently available. The Asian-lineage is the causative agent of major outbreaks across the globe and most of the current ZIKV vaccine candidates aim to provide homologous efficacy in ZIKV pre-clinical challenge models. In contrast, the African-lineage of ZIKV is mainly restricted to sylvatic transmission but not much is known about the ability of this virus to emerge from a sylvatic to human transmission. Efficacy of ZIKV vaccine in mice or macaques relies on the quantification of viraemia by RT-PCR. However, questions remain as to whether current ZIKV vaccine candidates offer lineage-transcending protection and viral clearance in key organs, such as the brain and reproductive tract. Here, we show the cross-protective capabilities of our previously reported simian adenoviral-vectored zika vaccines (ChAdOx1 ZIKV) against a heterologous African-ZIKV challenge model, in which A129 mice display a high susceptibility to ZIKV infection. Furthermore, we have assessed the ability of our vaccines to prevent infection in tissues such as the brain and ovaries, as both tissues are relevant for ZIKV pathogenesis. Finally, we describe a novel ChAdOx1 ZIKV vaccine design carrying a consensus antigen of the African-ZIKV lineage and tested its efficacy in a homologous challenge model.

show abstract

Section: Mainmentioning

confidence: 99%

A Zika vaccine based on chimpanzee adenovirus ChAdOx1 elicits lineage-transcending sterile immunity and prevents colonisation of brain and ovaries

López-Camacho

Dowall

Graham

et al. 2019

Preprint

View full text Add to dashboard Cite

show abstract

“…O surto na Polinésia Francesa, em 2013, revelou ainda uma associação entre infecção pelo ZIKV e a Síndrome de Guillain- Barré (OEHLER et al, 2014;PLATT et al, 2017), a qual se trata de uma doença autoimune, caracterizada por desmielinização periférica, resultando em paralisia ascendente e insuficiência respiratória, o que requer ventilação mecânica (PLATT et al, 2017). Nos últimos dois anos, a Síndrome de Guillain-Barré, associada ao ZIKV, foi relatada no Brasil e em diferentes países: Colômbia, Estados Unidos, Martinica e outros (NASCIMENTO et al, 2017;PROENCA-MODENA et al, 2018).…”

Section: Apresentações Clínicasunclassified

O impacto do vírus Zika no Brasil e no mundo

Tureta

Rosa

Berger

et al. 2019

View full text Add to dashboard Cite

Resumo O vírus Zika, transmitido por mosquitos do gênero Aedes, foi responsável recentemente por um grande surto de infecções e condições patológicas a ele associadas. Muitos casos de microcefalia e outras complicações neurológicas foram relacionados ao vírus, tornando-o alvo de diversas pesquisas no Brasil e no mundo. As investigações científicas, relacionadas ao Zika, em muito pouco tempo, já foram capazes de melhorar o diagnóstico, promover avanços no desenvolvimento de vacinas e outras maneiras de prevenção, bem como maior entendimento sobre as patologias associadas. Neste trabalho, todos esses aspectos foram revisados e discutidos, apresentando um panorama geral sobre o Zika e seu impacto global, especialmente no Brasil. Palavras-chave: Infecção. Zika. Microcefalia. Abstract The Zika virus, transmitted by mosquitoes of the genus Aedes, was recently responsible for a major outbreak of infections and pathological associated conditions. Several cases of microcephaly and other neurological impairments were related with the virus, making Zika a target of multiple research projects in Brazil and worldwide. Scientific investigations, related to Zika, have, in a short time, already been able to improve the diagnosis, promote advances in vaccine development and other ways of prevention, as well as a better understanding of the associated pathologies. In this article, these mentioned topics were reviewed and discussed presenting an overview towards Zika and its global impact, especially in Brazil. Keywords: Infection. Zika. Microcephaly.

show abstract

“…No obstante, se hizo una revisión de la literatura sobre la relación entre la infección por este virus y gemelos unidos, sin conseguir reportes al respecto, encontrándose sólo múltiple evidencia de anomalías neurológicas y oftálmicas producidas por el zika. 17 En el caso reportado el autosite presentó obstrucción parcial sintomática del extremo inferior del recto la cual mejoraba con la movilización de la masa parásita, por lo que al inicio se pensó que dichos síntomas desaparecerían con la cirugía, sin embargo persistieron, lo que obligó a la exploración a través de abordaje sagital posterior, momento en el que se evidenció disminución de cerca de 50% de la circunferencia del recto, 1 cm por encima de la línea pectínea. A pesar de que la estenosis rectal es un desorden del espectro de malformaciones anorectales descritas…”

Section: Figuraunclassified

Gemelo Heterópago

Fernández¹,

Marín²,

Tocuyo³

2019

Repert. Med. Cir.

View full text Add to dashboard Cite

Los gemelos parásitos o heterópagos son aquellos unidos asimétricos con partes deformes del parásito que se unen en diferentes regiones del gemelo normal (autosite), del cual depende para su soporte nutricional y crecimiento. Presentamos el caso de un gemelo heterópago con las extremidades inferiores y rudimentos de las superiores del parásito unidas al periné y glúteo derecho del autosite. Aunque no compartían órganos pélvicos, la compresión extrínseca de estructuras óseas del parásito causaron estenosis del recto, lo que obligó a la corrección quirúrgica. Los estudios por imágenes permitieron planificar la cirugía, lo cual facilitó la separación exitosa y lograr la sobrevida del paciente con muy buena calidad de vida. A pesar de ser reportados desde épocas ancestrales, aún generan gran interés debido a la variabilidad en su presentación clínica y al desconocimiento en su etiopatogénesis.

show abstract

Consequences of congenital Zika virus infection

Cited by 48 publications

References 80 publications

A Zika vaccine based on chimpanzee adenovirus ChAdOx1 elicits lineage-transcending sterile immunity and prevents colonisation of brain and ovaries

A Zika vaccine based on chimpanzee adenovirus ChAdOx1 elicits lineage-transcending sterile immunity and prevents colonisation of brain and ovaries

O impacto do vírus Zika no Brasil e no mundo

Gemelo Heterópago

Contact Info

Product

Resources

About