2014
DOI: 10.1093/neuonc/not321
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Consequences of cancer treatments on adult hippocampal neurogenesis: implications for cognitive function and depressive symptoms

Abstract: The human brain is capable of generating new functional neurons throughout life, a phenomenon known as adult neurogenesis. The generation of new neurons is sustained throughout adulthood due to the proliferation and differentiation of adult neural stem cells. This process in humans is uniquely located in the subgranular zone of the dentate gyrus in the hippocampus. Adult hippocampal neurogenesis (AHN) is thought to play a major role in hippocampus-dependent functions, such as spatial awareness, long-term memor… Show more

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Cited by 68 publications
(39 citation statements)
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“…Neurogenesis which has been shown to be involved in cognitive impairment and depression in humans and in a variety of rodent models, is a function of serotonergic regulation and may affect the response to antidepressants in both cognitive and affective behavioral domains (Adeosun et al, 2014;Alenina and Klempin, 2015;Anacker, 2014;Biscaro et al, 2012;Braun and Jessberger, 2014;Chadwick et al, 2011;Cho et al, 2015;Dimitrov et al, 2014;Gundersen et al, 2013;Hill et al, 2015;Jiang et al, 2015;Lin and Wang, 2014;Mendez-David et al, 2013;Morais et al, 2014;O'Leary and Cryan, 2014;Parihar et al, 2013;Pereira Dias et al, 2014;Ransome et al, 2012;Rotheneichner et al, 2014;Schoenfeld and Cameron, 2015;Seib et al, 2013;Serafini et al, 2014;Shetty, 2014;Suarez-Pereira et al, 2015;Yau et al, 2014). In young adult mice, antidepressants increase stem cell proliferation (Hodes et al, 2010;Santarelli et al, 2003;Tanti et al, 2013).…”
Section: Discussionmentioning
confidence: 99%
“…Neurogenesis which has been shown to be involved in cognitive impairment and depression in humans and in a variety of rodent models, is a function of serotonergic regulation and may affect the response to antidepressants in both cognitive and affective behavioral domains (Adeosun et al, 2014;Alenina and Klempin, 2015;Anacker, 2014;Biscaro et al, 2012;Braun and Jessberger, 2014;Chadwick et al, 2011;Cho et al, 2015;Dimitrov et al, 2014;Gundersen et al, 2013;Hill et al, 2015;Jiang et al, 2015;Lin and Wang, 2014;Mendez-David et al, 2013;Morais et al, 2014;O'Leary and Cryan, 2014;Parihar et al, 2013;Pereira Dias et al, 2014;Ransome et al, 2012;Rotheneichner et al, 2014;Schoenfeld and Cameron, 2015;Seib et al, 2013;Serafini et al, 2014;Shetty, 2014;Suarez-Pereira et al, 2015;Yau et al, 2014). In young adult mice, antidepressants increase stem cell proliferation (Hodes et al, 2010;Santarelli et al, 2003;Tanti et al, 2013).…”
Section: Discussionmentioning
confidence: 99%
“…In humans, many cancer therapies impair the survival of dividing cells indiscriminately and likely ablate AHN [45]. Following cancer treatment, patients often have impairment in hippocampus dependent memory, and depression and anxiety is common among patients undergoing treatment for cancer [45,46].…”
Section: Evidence That Impaired Ahn Is Sufficient To Induce Depressiomentioning
confidence: 99%
“…Following cancer treatment, patients often have impairment in hippocampus dependent memory, and depression and anxiety is common among patients undergoing treatment for cancer [45,46]. These effects following cancer treatments may be due to impaired AHN, but there are clearly too many confounding factors to draw a causal link.…”
Section: Evidence That Impaired Ahn Is Sufficient To Induce Depressiomentioning
confidence: 99%
“…Together, these findings suggest that hippocampal neurogenesis plays a critical role in hippocampal-dependent domains of cognition. Chemotherapy drugs suppress cell proliferation, including newly generated hippocampal neurons in both human and animal models (Pereira Dias, Hollywood, Bevilaqua, da Luz, Hindges, Nardi, and Thuret, 2014; Winocur, Wojtowicz, and Tannock, 2015). Decreased hippocampal neurogenesis has been documented following treatment with multiple chemotherapy drugs both individually (Janelsins, Roscoe, Berg, Thompson, Gallagher, Morrow, Heckler, Jean-Pierre, Opanashuk, and Gross, 2010) and when treated in combination (Briones and Woods, 2011; Christie, Acharya, Parihar, Nguyen, Martirosian, and Limoli, 2012; Winocur et al, 2015) and may accompany CICI induced by paclitaxel.…”
Section: Introductionmentioning
confidence: 99%