Consequences of axonal transport blockade induced by batrachotoxin on mammalian neuromuscular junction I. early pre- and postsynaptic changes

Boegman, R.J.; Deshpande, Shripad B.; Albuquerque, Edson X.

doi:10.1016/0006-8993(80)90503-x

Cited by 40 publications

(2 citation statements)

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“…1 ). Our basic strategy was to use a condition-test approach, in a combination of in vivo and ex vivo paradigms and in vitro physiological and morphological measurements, which has proved successful in exploring modifiers and their mechanisms in other contexts, for instance, axonal degeneration and regeneration ( McQuarrie et al, 1977; Boegman et al, 1980; Deshpande et al, 1981; Hudson et al, 1984; Lund et al, 2002; Beirowski et al, 2004; Beirowski et al, 2005; Wong et al, 2009; Oyebode et al, 2012 ). Our assays were conducted on isolated nerve-muscle preparations of hind toe muscles: specifically flexor digitorum brevis (FDB) or one of the four deep lumbrical muscles (1–4DL).…”

Section: Methodsmentioning

confidence: 99%

Activity-dependent degeneration of axotomized neuromuscular synapses in WldS mice

et al. 2015

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Section: Methodsmentioning

confidence: 99%

Activity-dependent degeneration of axotomized neuromuscular synapses in WldS mice

et al. 2015

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“…3). Because tetrodotoxin causes disuse with no effect on axonal transport (Boegman et al, 1980;Drachman et al,…”

Section: P a Bernard Et Almentioning

confidence: 99%

Increased Cytosolic Androgen Receptor Binding in Rat Striated Muscle Following Denervation and Disuse

Bernard

Ranee

Fishman

et al. 1984

Journal of Neurochemistry

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We investigated the effects of denervation and disuse on cytosolic androgen receptor binding by rat striated muscle. Denervation of the extensor digitorum longus and tibialis anterior muscles caused a 40-50% increase in cytosolic androgen receptor concentration with no change in apparent binding affinity. This effect was evident at 6 h postdenervation, maximal at 24 h, and declined to 120% of the control level 72 h after denervation. A 40% increase in cytosolic androgen receptor concentration was also noted 24 hr after denervation of the hormone-sensitive levator ani muscle. The effect of denervation on androgen receptors was not blocked by in vivo injection of cycloheximide; therefore, de novo receptor synthesis probably is not involved in the observed increase. Disuse, produced by subperineurial injection of tetrodotoxin into the tibial and common peroneal branches of the sciatic nerve, mimicked the effect of denervation on androgen receptor binding, suggesting that neuromuscular activity is important in regulation of receptor concentration. Possible mechanisms subserving this effect are discussed.

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The role of axonal transport and impulse conduction on the uptake and retrograde transport of nerve growth factor and bovine serum albumin in peripheral nerve

Boegman

Riopelle

1980

J. Neurobiol.

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Consequences of axonal transport blockade induced by batrachotoxin on mammalian neuromuscular junction I. early pre- and postsynaptic changes

Cited by 40 publications

References 39 publications

Activity-dependent degeneration of axotomized neuromuscular synapses in WldS mice

Activity-dependent degeneration of axotomized neuromuscular synapses in WldS mice

Increased Cytosolic Androgen Receptor Binding in Rat Striated Muscle Following Denervation and Disuse

The role of axonal transport and impulse conduction on the uptake and retrograde transport of nerve growth factor and bovine serum albumin in peripheral nerve

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