Conséquences andrologiques de l’insuffisance rénale chronique : état de l’art pour le rapport annuel de l’Association française d’urologie

Thuret, Rodolphe; Kleinclauss, F.; Timsit, Marc‐Olivier

doi:10.1016/j.purol.2016.08.013

Cited by 7 publications

(6 citation statements)

References 44 publications

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“…4,41 This results in functional hypogonadotropic hypogonadism in patients with CKD. 5 Hyperprolactinemia is a multifactorial condition in this population, and probably an increase in dialysance to increase prolactin clearance or drugs that decrease prolactin levels will help manage hyperprolactinemia; the risk-benefit ratio should be evaluated in both cases. 20 Prolactin is available in the circulation in several forms, one of which is macroprolactin, which has reduced or absent bioactivity.…”

Section: Discussionmentioning

confidence: 99%

“…A direct action of hyperprolactinemia at the level of Leydig cells is suggested, which suppresses testosterone secretion 4,41 . This results in functional hypogonadotropic hypogonadism in patients with CKD 5 . Hyperprolactinemia is a multifactorial condition in this population, and probably an increase in dialysance to increase prolactin clearance or drugs that decrease prolactin levels will help manage hyperprolactinemia; the risk–benefit ratio should be evaluated in both cases 20 .…”

Section: Discussionmentioning

confidence: 99%

“…Although hypogonadism can improve for up to 2 years after kidney transplantation, it persists in approximately 25% of CKD patients. [4][5][6] The pathophysiology of pubertal disorders (PD) in men with CKD is multifactorial. 7 One factor is the absence of an adequate pulsatile release of gonadotropin-releasing hormone (GnRH) from the hypothalamus, leading to loss of the normal pulse of luteinizing hormone (LH), with decreased testosterone secretion by the testes resulting in decreased testosterone levels.…”

mentioning

confidence: 99%

“…The reported prevalence of hypogonadism is 24–66%. Although hypogonadism can improve for up to 2 years after kidney transplantation, it persists in approximately 25% of CKD patients 4–6 …”

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confidence: 99%

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Leptin receptor and prolactin in pubertal disorders and chronic kidney disease

Villasis-Keever

Zurita‐Cruz

Serret-Montoya

et al. 2022

Pediatrics International

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Background Knowledge of chronic kidney disease (CKD) with pubertal disorders (PD) in adolescent boys is limited as few studies have explored this disorder. This study aimed to identify the usefulness of assessing hormonal parameters in male adolescents with CKD and their correlation with PD in a 12‐month follow‐up period. Methods A prospective cohort study was conducted among male adolescents with CKD (stages IV and V). Data regarding the age at puberty onset were collected from the patients’ clinical records and through interview. The patients were followed up for 12 months during their pubertal development. At the beginning, routine hormonal profile tests were performed to examine the patients’ thyroid profile, prolactin levels, luteinizing hormone, follicle‐stimulating hormone, testosterone, leptin, and receptor leptin. The hormonal profiles of patients with and without PD were compared. Comparisons between the groups were performed using the Student t‐test and Fisher's exact tests. Logistic regression analysis was also performed. Results Data of 64 patients (26/64 with PD) were analyzed. The median age was 15 years and the median time for CKD evolution was 11 months. No differences between groups were noted in the general or biochemical characteristics of the patients. The hormonal parameters, prolactin levels were higher and the free leptin and free thyroxine levels were lower in patients with PD. Leptin receptor levels of >0.90 ng/mL (risk ratio [RR], 8.6; P = 0.004) and hyperprolactinemia (RR, 21.3; P = 0.049) were the risk factors for PD. Conclusions Leptin receptor levels of >0.90 ng/mL and hyperprolactinemia are associated with the development of PD in male adolescents with CKD.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

mentioning

confidence: 99%

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Leptin receptor and prolactin in pubertal disorders and chronic kidney disease

Villasis-Keever

Zurita‐Cruz

Serret-Montoya

et al. 2022

Pediatrics International

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“…This is due to several factors that directly or indirectly compromise spermatogenesis, and consequently, the seminal quality. These factors include hypogonadism, 4 uremia, 5 infection and inflammation, 6 reactive oxygen species, 7 and immunological alterations. 8 The significance of changes in fertility in these patients is neglected due to the visible complications resulting from complete renal failure and the dependence on hemodialysis.…”

Section: Introductionmentioning

confidence: 99%

Seminal Levels of Immunoglobulins and Complements and Their Relationship with Seminal Parameters in Chronic Hemodialytic Patients

Silva¹,

Grangeiro²,

Oliveira³

2021

International Journal of Infertility &Amp; Fetal Medicine

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Aim and objective: To investigate the potential relationship between seminal complements (C3 and C4) and immunoglobulin (IgA and IgG) levels and seminal parameters (SPs) in chronic hemodialysis patients. Materials and methods: A cross-sectional study was conducted among patients aged between 18 years and 60 years. The sample comprises 60 males undergoing hemodialysis for >6 months, and 15 healthy males without clinical or laboratory signs of genitourinary and eugonadic tract infections. Spermograms and leukocytopermia, serum hormonal profiles, and seminal measurements of complement fractions (C3, C4) and immunoglobulins (IgA, IgG) were performed. Results: The hemodialysis and healthy groups were similar in age (49.47 ± 05.55 and 50.53 ± 04.24 years, p = 0.06). Average levels of seminal C fractions (C3, C4) were similar between the hemodialysis and healthy groups, between normozoospermia and oligozoospermia hemodialysis subgroups, and in the oligozoospermia hemodialysis subgroup. Average seminal levels of Igs (A and G) differed significantly between the hemodialysis and healthy groups (351.60 ± 035.80 vs 247.40 ± 39.00 mg/L), and in normozoospermia and oligozoospermia hemodialysis subgroups (361.20 ± 36.30 vs 340.60 ± 32.50 mg/L). However, they were similar (p > 0.05) between subgroups of oligozoospermia. The seminal fractions of complete (C3 and C4) and Ig (A and G) did not correlate (p > 0.05) with SPs. All participants had hormonal profiles within the normal range. Conclusion:The complement fractions (C3 and C4) and immunoglobulins (IgA and IgG) showed no relationship with SPs in chronic hemodialysis patients.

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Testicular Dysfunction in Systemic Diseases

Sartorius,

Handelsman

2023

Andrology

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Conséquences andrologiques de l’insuffisance rénale chronique : état de l’art pour le rapport annuel de l’Association française d’urologie

Cited by 7 publications

References 44 publications

Leptin receptor and prolactin in pubertal disorders and chronic kidney disease

Leptin receptor and prolactin in pubertal disorders and chronic kidney disease

Seminal Levels of Immunoglobulins and Complements and Their Relationship with Seminal Parameters in Chronic Hemodialytic Patients

Testicular Dysfunction in Systemic Diseases

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