Conséquences à long terme des enfants nés dans un contexte de retard de croissance intra-utérin et/ou petits pour l’âge gestationnel

Gascoin, Géraldine; Flamant, Cyrille

doi:10.1016/j.jgyn.2013.09.014

Cited by 34 publications

(5 citation statements)

References 65 publications

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“…However, on the functional level, no difference was observed. This is consistent with the findings of studies conducted in HMICs, which observed that undernutrition in childhood was not associated with disabilities in carrying out daily tasks (household and professional) in adulthood [58,59]. This may be due to the benefit of nutritional rehabilitation and catch-up growth after treatment, promoting the social reintegration of malnutrition survivors by making them autonomous in daily life, despite their cognitive disabilities.…”

Section: Plos Onesupporting

confidence: 90%

Long-term effects of severe acute malnutrition during childhood on adult cognitive, academic and behavioural development in African fragile countries: The Lwiro cohort study in Democratic Republic of the Congo

et al. 2020

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Introduction Little is known about the outcomes of subjects with a history of severe acute malnutrition (SAM). We therefore sought to explore the long-term effects of SAM during childhood on human capital in adulthood in terms of education, cognition, self-esteem and health-related disabilities in daily living. Methodology We traced 524 adults (median age of 22) in the eastern Democratic Republic of the Congo, who were treated for SAM during childhood at Lwiro hospital between 1988 and 2007 (median age 41 months). We compared them with 407 community controls of comparable age and sex. Our outcomes of interest were education, cognitive function [assessed using the Mini Mental State Examination (MMSE) for literate participants, or its modified version created by Ertan et al. (MMSE-I) for uneducated participants], self-esteem (measured using the Rosenberg Self-Esteem Scale) and health-related social and functional disabilities measured using the World Health Organization Disability Assessment Schedule (WHODAS). For comparison, we used the Chi-squared test along with the Student’s t-test for the proportions and means respectively. Results Compared with the community controls, malnutrition survivors had a lower probability of attaining a high level of education (p < 0.001), of reporting a high academic performance (p = 0.014) or of having high self-esteem (p = 0.003). In addition, malnutrition survivors had an overall mean score in the cognitive test that was lower compared with the community controls [25.6 compared with 27.8, p = 0.001 (MMSE) and 22.8 compared with 26.3, p < 0.001(MMSE-I)] and a lower proportion of subjects with a normal result in this test (78.0% compared with 90.1%, p < 0.001). Lastly, in terms of health-related disabilities, unlike the community controls, malnutrition survivors had less social disability (p = 0.034), but no difference was observed as regards activities of daily living (p = 0.322). Conclusion SAM during childhood exposes survivors to low human capital as regards education, cognition and behaviour in adulthood. Policy-deciders seeking to promote economic growth and to address various psychological and medico-social disorders must take into consideration the fact that appropriate investment in child health as regards SAM is an essential means to achieve this.

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Section: Plos Onesupporting

confidence: 90%

Long-term effects of severe acute malnutrition during childhood on adult cognitive, academic and behavioural development in African fragile countries: The Lwiro cohort study in Democratic Republic of the Congo

et al. 2020

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“…If the fetus is dissociated from the uterus too early, then the lack of rhythm of the environmental sound stimuli could influence language development (Herold et al, 2008), and the earlier the gestational age, the more delayed the language development (Schirmer et al, 2006). A prospective study performed by Allin et al (2008) (Gascoin & Flamant, 2013).…”

Section: Discussionmentioning

confidence: 99%

“…PTB children are at higher risk for attention deficiency and hyperactivity disorder, which mainly manifest as learning difficulties or borderline intelligence levels in children. Attention deficiency in PTB children generally appears secondary to behavioral issues and has long‐term influences on subsequent cognitive development and social adaptability (Gascoin & Flamant, 2013 ).…”

Section: Discussionmentioning

confidence: 99%

Long‐term effects of prenatal magnesium sulfate exposure on nervous system development in preterm‐born children

Zhou,

Liu,

Yan

et al. 2023

Food Science & Nutrition

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This study used structural magnetic resonance imaging to analyze changes in the gray matter volume (GMV) of preterm‐born (PTB) and term‐born (TB) children to help elucidate the influence of magnesium sulfate treatment on the nervous system development. A total of 51 subjects were recruited, including 28 PTB and 23 TB children. The intelligence scale and MRI scan were completed at the corrected age of 10 to 16 years. A whole‐brain voxel‐wise analysis tested the main effect of the status (PTB without magnesium, PTB with magnesium, and TB) using a factorial design in SPM8. The mean volumes of the regions that showed significant group effects on the GMV after the FDR correction were extracted in the common space for each subject. Verbal and full‐scale intelligence quotient scores were significantly lower for PTB children without magnesium than for TB children; however, the scores of PTB children with magnesium and TB children were almost identical. Compared with TB children, PTB children had significantly reduced left straight gyrus and left inferior frontal gyrus GMVs; however, the volumes of PTB children with magnesium were closer to those of TB children. Changes in the GMV of the left inferior frontal gyrus were significantly correlated with full‐scale and verbal intelligence quotient scores, whereas the lower gestational age at the time of mgsou4 treatment led to a larger GMV of the left inferior frontal gyrus. Brain structural abnormalities could exist in PTB children. The GMVs of the left straight gyrus and left inferior frontal gyrus were significantly reduced in these children. The influence of magnesium sulfate treatment was not significant, but the cognitive levels of these children were significantly increased and almost identical to those of TB children. Initiation of magnesium sulfate treatment during gestation is negatively correlated with the left inferior frontal gyrus GMV.

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“…Generally, fetuses with IUGR catch up in terms of their height during the second year of life, often as early as one year [ 120 , 121 , 122 ]. A child over 3 years of age who has still not caught up to his height should be taken care of by a pediatrician endocrinologist for in-depth examinations on stature delay, with a view initiating growth hormone treatment from the age of four [ 121 , 122 , 123 , 124 ]. It should be added that in cases of IUGR, cerebral maturation is generally not affected [ 125 , 126 ].…”

Section: Discussionmentioning

confidence: 99%

Age-at-Death Estimation of Fetuses and Infants in Forensic Anthropology: A New “Coupling” Method to Detect Biases Due to Altered Growth Trajectories

Niel

Chaumoître

Adalian

2022

Biology

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The coupling between maturation and growth in the age estimation of young individuals with altered growth processes was analyzed in this study, whereby the age was determined using a geometric morphometrics method. A medical sample comprising 223 fetuses and infants was used to establish the method. The pars basilaris shapes, quantified by elliptic Fourier analysis, were grouped into consensus stages to characterize the maturation process along increasing age groups. Each pars basilaris maturation stage was “coupled” to biometry by defining an associated femur length range. The method was tested on a validation sample of 42 normal individuals and a pathological sample of 114 individuals whose pathologies were medically assessed. Couplings were present in 90.48% of the normal sample and 77.19% of the pathological sample. The method was able to detect “uncoupling” (i.e., possibly altered growth) in more than 22.8% of samples, even if there was no visible traces of pathology on bones in most cases. In conclusion, experts should be warned that living conditions may cause alterations in the development of young individuals in terms of uncoupling, and that the age-at-death estimation based on long bone biometry could be biased. In a forensic context, when age has been estimated in cases where uncoupling is present, experts should be careful to take potential inaccuracies into account when forming their conclusions.

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Conséquences à long terme des enfants nés dans un contexte de retard de croissance intra-utérin et/ou petits pour l’âge gestationnel

Cited by 34 publications

References 65 publications

Long-term effects of severe acute malnutrition during childhood on adult cognitive, academic and behavioural development in African fragile countries: The Lwiro cohort study in Democratic Republic of the Congo

Long-term effects of severe acute malnutrition during childhood on adult cognitive, academic and behavioural development in African fragile countries: The Lwiro cohort study in Democratic Republic of the Congo

Long‐term effects of prenatal magnesium sulfate exposure on nervous system development in preterm‐born children

Age-at-Death Estimation of Fetuses and Infants in Forensic Anthropology: A New “Coupling” Method to Detect Biases Due to Altered Growth Trajectories

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