Consequence of concurrent use of chloroquine and hydroalcoholic extract of Balanites aegyptiaca and leaf leatx of Aloe camperi

Abstract

Prescription and/or over the counter medications when taken together with certain foods or herbal substances, leads to either increase or decrease a drug’s therapeutic out comes or adverse effects. It has been reported that a number of plant materials alter some pharmacokinetic parameters of chloroquine when administered concurrently. In some malarious areas of Ethiopia like Tigray region where chloroquine is used as antimalarial drug, medicinal and/or food plants are commonly consumed as herbal medicines or as food items. Thus, this study was aimed to evaluate the potential consequence of oral co-administration of hydroalcoholic fruit extract of Balanites aegyptiaca and leaf latex of Aloe camperi on the antimalarial effectiveness of chloroqine. Extract alone and extract in combination with chloroquine were tested against plasmodium berghie infected mice using peters four day suppressive method. Acute toxicity study was also carried out. The present study revealed that concurrent administrations of leaf extract of Balanites aegyptiaca and leaf leatx of Aloe camperi was found to increase parasitemia suppression potential of chloroquine. From the study it can be concluded that Balanites aegyptiaca and leaf leatx of Aloe camperi can potentiate malaria suppression of chloroquine.

Herbal Medicines: A Potent Approach to Human Diseases, Their Chief Compounds, Formulations, Present Status, and Future Aspects

“…Gynostemma pentaphyllum and Moringa oleifera's extract demonstrated a promising future for development as an antimalarial combination therapy [96]. The effects of co-administration of Balanites aegyptiaca hydroalcoholic fruit extract and Aloe camperi leaf latex on the antimalarial action of chloroquine were examined [97].…”