Consensus statement * on the treatment of allergic rhinitis

Cauwenberge, Paul Van; Bachert, Claus; Passalacqua, G.; Bousquet, Jean; Canonica, Giorgio Walter; Durham, Stephen R.; Fokkens, Wytske J.; Howarth, Peter H.; Lund, VJ; Malling, Hans‐Jørgen; Mygind, Niels; Passàli, Desiderio; Scadding, Glenis; Wang, D Y

doi:10.1034/j.1398-9995.2000.00526.x

Cited by 576 publications

(390 citation statements)

References 147 publications

Supporting

Mentioning

353

Contrasting

Unclassified

Order By: Relevance

“…21 Serum IgE levels and eosinophil count have a secondary importance in the diagnosis of atopy in this study, since neither of them was significant after the multivariate analysis. Levels of specific IgE antibodies to inhalant allergens, albeit more reliable for the diagnosis of atopy, 5 were not determined in this study due to the high cost of this test.…”

Section: Methodsmentioning

confidence: 99%

“…The skin prick test is quick, inexpensive and easy to perform and standardize, being an important tool in the diagnosis of IgE-mediated sensitivity. 5,6,8 Its results…”

Section: Methodsmentioning

confidence: 99%

“…5,6 Only 13.6% of mouth-breathers in our study used mattress and pillow covers. As this is an important measure, 5,6 it was recommended for all those patients with a positive ST. On the other hand, the fact that atopic patients had a significantly lower number of smokers at home and a smaller number of people sleeping in the same room, compared to nonatopic patients, may represent intervention measures by the family.…”

Section: Methodsmentioning

confidence: 99%

“…1,4 Among inflammatory disorders, allergic rhinitis plays a key role, since it affects approximately 10 to 30% of the general population, 1 and its incidence has been increasing in the last decades all over the world. 5,6 The aim of this study was to assess the presence of atopy among mouth-breathing patients referred to a tertiary care center in the metropolitan region of Belo Horizonte, Brazil, and to determine the prevalence and sensitization to aeroallergens, as well as to identify clinical and laboratory factors related to the presence of atopy in these patients.…”

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Avaliação de atopia em crianças respiradoras bucais atendidas em centro de referência

Barros¹,

Becker²,

Pinto³

2006

J. Pediatr. (Rio J.)

View full text Add to dashboard Cite

Objective: A mouth breather is someone who uses his/her oral cavity as main airway during breathing. This is a syndrome with several etiologies, but allergic rhinitis plays a key role due to its high prevalence. The aim of this study was to assess the presence of atopy among mouth-breathing patients referred to a tertiary care center in the metropolitan region of Belo Horizonte, Brazil.Methods: Cross-sectional, descriptive study carried out at Hospital das Clínicas of Universidade Federal de Minas Gerais. Patients aged 2 to 12 years, admitted between November 2002 and April 2004, were included. Parents or surrogates completed a comprehensive questionnaire, and patients were submitted to a skin test for inhalant allergens. A total of 140 patients participated in the study. Those with a positive result for at least one allergen were regarded as atopic. The statistical analyses were made using SPSS, with univariate analyses followed by logistic regression.Results: Of 140 patients, 44.3% (62/140) obtained positive results on the allergic test. Mites were the most predominant allergens, with a positive rate of 100% among atopic patients. In the multivariate analysis, atopy was significantly associated with the male sex (p = 0.05), presence of asthma (p = 0.014), lower number of people sleeping in the same room with the patient (p = 0.005), absence of passive smoking (p = 0.005) and absence of sleep apnea (p = 0.003). Conclusion:The high prevalence of positive results on the allergic test highlights the importance of allergologic investigation in mouth-breathers, since allergy has specific treatments that may reduce morbidity in these patients when properly used.J Pediatr (Rio J). 2006;82(6):458-64: Atopy, allergic rhinitis, mouth-breathers, allergen, dust mites.

show abstract

Section: Methodsmentioning

confidence: 99%

“…The skin prick test is quick, inexpensive and easy to perform and standardize, being an important tool in the diagnosis of IgE-mediated sensitivity. 5,6,8 Its results…”

Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Avaliação de atopia em crianças respiradoras bucais atendidas em centro de referência

Barros¹,

Becker²,

Pinto³

2006

J. Pediatr. (Rio J.)

View full text Add to dashboard Cite

show abstract

“…In patients with allergic rhinitis, antihistamines relieve symptoms such as rhinorrhoea, sneezing and itching but are generally less effective against nasal congestion (21). They are also effective at reducing the symptoms of urticaria, such as wheals and itching (5).…”

Section: Role Of Antihistaminesmentioning

confidence: 99%

Ebastine in allergic rhinitis and chronic idiopathic urticaria

Sastre

2008

Allergy

View full text Add to dashboard Cite

Histamine is a key mediator in the development of allergy symptoms, and oral H1‐antihistamines are among the most widely used treatments for symptomatic relief in conditions such as allergic rhinitis and chronic urticaria. Ebastine is a second‐generation antihistamine which has been shown to be an effective treatment for both seasonal and perennial allergic rhinitis. In controlled clinical trials in adult and adolescent patients with allergic rhinitis, ebastine 10 mg once‐daily improved symptoms to a significantly greater extent than placebo and to a similar extent as loratadine 10 mg and cetirizine 10 mg (both once‐daily), while ebastine 20 mg proved to be more effective than these two comparator antihistamines. In addition, ebastine was significantly more effective than placebo at relieving the symptoms of chronic idiopathic urticaria. Ebastine provides efficacy throughout the 24‐h dosing interval with once‐daily administration and clinical benefit is seen from the first day of treatment. Small studies have found beneficial effects for ebastine in patients with other disorders, including cold urticaria, dermographic urticaria, atopic asthma, mosquito bites and (in combination with pseudoephedrine) the common cold. In addition to the regular ebastine tablet, a fast‐dissolving tablet (FDT) formulation, which disintegrates in the mouth without the aid of a drink, is also available. It has been shown to be bioequivalent to the regular tablet, and to be significantly more effective than desloratadine at reducing histamine‐induced cutaneous wheals. A number of patient surveys demonstrated that the majority of individuals who tried the fast‐dissolving formulation reported it to be convenient for use, fast‐acting and preferred it to their previous antihistamine medication. Perhaps most importantly, a large proportion of patients indicated that they would prefer to use this new formulation in the future. Ebastine has a rapid onset of action and it can be administered once‐daily, with or without food. Dose modifications are not needed in elderly patients, or in those with renal or mild to moderate hepatic impairment. Ebastine is generally well‐tolerated, and clinical studies showed that at usual therapeutic doses of 10 and 20 mg once‐daily, it had no clinically relevant adverse effects on cognitive function and psychomotor performance or on cardiovascular function. In conclusion, ebastine is an effective and generally well‐tolerated treatment for allergic rhinitis and chronic idiopathic urticaria. In addition to the regular tablet formulation, ebastine is available as a FDT, providing a treatment option that is particularly convenient for patients.

show abstract