Consensus recommendations for the treatment of basal cell carcinomas in <scp>G</scp>orlin syndrome with topical methylaminolaevulinate‐photodynamic therapy

Basset-Séguin, Nicole; Bissonnette, Robert; Girard, Christian; Hædersdal, Merete; Lear, John T.; Paul, C.; Piaserico, Stefano

doi:10.1111/jdv.12150

Cited by 45 publications

(38 citation statements)

References 42 publications

(97 reference statements)

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“…MAL-PDT is now approved in several countries for treating superficial and nodular BCC in this patient group [94]. It is also suitable for paediatric patients and the use of ropivacaine-lidocaine tumescent anaesthesia has been reported to increase tolerability [88].…”

Section: Gorlin Syndromementioning

confidence: 99%

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Photodynamic Therapy and Non-Melanoma Skin Cancer

Griffin

Lear

2016

Cancers

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Non-melanoma skin cancer (NMSC) is the most common malignancy among the Caucasian population. Photodynamic therapy (PDT) is gaining popularity for the treatment of basal cell carcinoma (BCC), Bowen’s disease (BD) and actinic keratosis (AK). A topical or systemic exogenous photosensitiser, results in selective uptake by malignant cells. Protoporphyrin IX (PpIX) is produced then activated by the introduction of a light source. Daylight-mediated MAL (methyl aminolaevulinate) PDT for AKs has the advantage of decreased pain and better patient tolerance. PDT is an effective treatment for superficial BCC, BD and both individual and field treatment of AKs. Excellent cosmesis can be achieved with high patient satisfaction. Variable results have been reported for nodular BCC, with improved outcomes following pretreatment and repeated PDT cycles. The more aggressive basisquamous, morphoeic infiltrating subtypes of BCC and invasive squamous cell carcinoma (SCC) are not suitable for PDT. Prevention of “field cancerization” in organ transplant recipients on long-term immunosuppression and patients with Gorlin syndrome (naevoid basal cell carcinoma syndrome) is a promising development. The optimisation of PDT techniques with improved photosensitiser delivery to target tissues, new generation photosensitisers and novel light sources may expand the future role of PDT in NMSC management.

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Section: Gorlin Syndromementioning

confidence: 99%

“…A European consensus on MAL-PDT in Gorlin syndrome was published in 2014. This recommended MAL-PDT as a safe and effective alternative to surgery for all superficial BCCs and nodular BCCs <2 mm thickness [94]. …”

Section: Gorlin Syndromementioning

confidence: 99%

Photodynamic Therapy and Non-Melanoma Skin Cancer

Griffin

Lear

2016

Cancers

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“…However, the treatment is painful, inducing a burning effect and often requiring the use of local anaesthesia, nerve blocks, tumescent anaesthesia and cooling before treatment. 40 Topical photodynamic therapy is suggested for lesions < 2 mm, while systemic photodynamic therapy is suggested for larger lesions. 41,42 Chemotherapeutics Chemotherapeutic agents include topical 5-fluorouracil and imiquimod.…”

Section: Destructive Treatmentmentioning

confidence: 99%

Basal cell naevus syndrome: an update on genetics and treatment

John

Schwartz

2015

Br J Dermatol

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Basal cell naevus syndrome is an autosomal dominant disorder that stems from mutations in multiple genes, most commonly patched 1 (PTCH1). The classic triad of symptoms consists of basal cell carcinomas, jaw keratocysts and cerebral calcifications, although there are many other systemic manifestations. Because of the broad range of symptoms and development of several types of tumours, early diagnosis and close monitoring are essential to preserve quality of life. Targeting treatment is often difficult because of tumour prevalence. Newer inhibitors of the hedgehog signalling pathway and proteins involved in proliferative growth have shown therapeutic promise. In addition, preventive medications are being devised. We propose a method for determining appropriate treatment for cutaneous tumours.

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“…Autorzy konsensusu zalecali, aby częstość wizyt kontrolnych była uzależniona od liczby ognisk BCC, częstości nawrotów oraz lokalizacji zmian. Jako istotną zaletę terapii fotodynamicznej podkreślono możliwość równoczesnego leczenia wielu zmian [22].…”

Section: Metoda Fotodynamicznaunclassified

Zalecenia dotyczące leczenia chorych na raka podstawnokomórkowego i na raka kolczystokomórkowego przygotowane przez Sekcję Onkologiczną Polskiego Towarzystwa Dermatologicznego i sekcję Akademia Czerniaka Polskiego Towarzystwa Chirurgii Onkologicznej

Owczarek¹,

Rutkowski²,

Słowińska³

et al. 2016

Nowotwory. Journal of Oncology

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Basal cell carcinoma (BCC) as well as the squamous cell carcinoma (SCC) are the most frequent malignant neoplasms among Caucasian patients. Despite the fact, that they seldom metastasise and are not directly fatal, they constitute a significant clinical issue. Such cancers infiltrate surrounding tissues and destroy the surrounding structures, e.g., bones and cartilages. This results in such structures developing severe defects and significantly reduces the quality of life of the patients. Those with chronic immunosuppresion or a genetic predisposition to develop UV-induced skin cancer are at risk of dying, particularly if the cancer is aggressive. The Oncology Department of the Polish Dermatology Society (Polish: Sekcja Onkologiczna Polskiego Towarzystwa Dermatologicznego-PTD) as well as the Melanoma Academy Department of the Polish Society of Oncological Surgery (Polish: sekcja Akademia Czerniaka Polskiego Towarzystwa Chirurgii Onkologicznej-PTChO), basing on the current European guidelines, American recommendations of the National Comprehensive Cancer Network (revision 1.2015) and interventional reviews of publications elaborated by the Cochrane Skin Group, attempted to systemise the diagnostic and therapeutic procedures and o determine rules for primary and secondary prevention in patients suspected/diagnosed with a basal cell or squamous cell carcinoma. The paper presents recommendations regarding diagnosis and treatment of skin cancers, taking all related benefits and challenges into consideration, as well as recommendations for post treatment patients monitoring.

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Consensus recommendations for the treatment of basal cell carcinomas in Gorlin syndrome with topical methylaminolaevulinate‐photodynamic therapy

Abstract: MAL-PDT is safe and effective in patients with Gorlin syndrome. Utilization of these recommendations may improve efficacy and clearance rates in this population.

Cited by 45 publications

References 42 publications

Photodynamic Therapy and Non-Melanoma Skin Cancer

Photodynamic Therapy and Non-Melanoma Skin Cancer

Basal cell naevus syndrome: an update on genetics and treatment

Zalecenia dotyczące leczenia chorych na raka podstawnokomórkowego i na raka kolczystokomórkowego przygotowane przez Sekcję Onkologiczną Polskiego Towarzystwa Dermatologicznego i sekcję Akademia Czerniaka Polskiego Towarzystwa Chirurgii Onkologicznej

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