Consensus on the tertiary prevention of primary liver cancer

Xu, Xiaoyuan; Dong, Shiming; Yang, Min; Li, Ling; Zhao, Suxian; Jia, Ji-dong; Wei, Lai; Zhang, Hui; Chen, Hongsong; Ding, Huiguo; Duan, Zhongping; Fan, Jian‐Gao; Gao, Yanhang; Hu, He; Huang, Jianrong; Li, Jun; Li, Wencong; Li, Wengang; Liu, Jingfeng; Liu, Lingdi; Nan, Yuemin; Ren, Wei; Shang, Jia; Wang, Maorong; Xie, Wei; Zeng, Meng Su; Zhang, Yuguo; Zhao, Jingmin; Zhao, Suisheng; Zhao, Wenjie; Zhou, Jian

doi:10.1007/s12072-023-10549-2

Cited by 3 publications

(5 citation statements)

References 96 publications

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“…Recurrence is consistently a crucial concern in curative treatment for HCC, prompting studies aimed at predicting the likelihood of recurrence. The ERASL model that included over 3000 cases showed that the male sex, ALBI grade, microscopic invasion, AFP, tumor size, and number of lesions could be incorporated to predict the possibility at a cut-off value; furthermore, the model indicated that risk factors could be stratified from low- to high-risk groups [ 19 , 20 , 21 ]. Higher serologic factors, such as AFP and des-γ-carboxyprothrombin (DCP), tumor volume, multiple nodules, microvascular invasion, and poorly differentiated types have been assumed to be aggressive tumor factors.…”

Section: Discussionmentioning

confidence: 99%

Recurrence Pattern Is an Independent Surgical Prognostic Factor for Long-Term Oncological Outcomes in Patients with Hepatocellular Carcinoma

Hsu,

Tang,

Huang

et al. 2024

Biomedicines

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Background: The perioperative outcomes of a partial hepatectomy for hepatocellular carcinoma (HCC) have improved. However, high recurrence rates after a curative hepatectomy for HCC is still an issue. This study aimed to analyze the difference between various recurrence patterns. Methods: We retrospectively reviewed 754 patients with HCC who underwent a curative hepatectomy between January 2012 and March 2021. Patients with recurrent events were categorized into three types: regional recurrence (type I), multiple intrahepatic recurrence (type II), or presence of any distant metastasis (type III). Results: The median follow-up period was 51.2 months. Regarding recurrence, 375 (49.7%) patients developed recurrence, with 244 (32.4%), 51 (6.8%), and 80 (10.6%) patients having type I, II, and III recurrence, respectively. Type III recurrence appeared to be more common in male patients and those with major liver resection, vascular invasion, a large tumor size (>5 cm), a higher tumor grade, and higher levels of AST and AFP (p < 0.05). Patients who had distant metastasis at recurrence had the shortest recurrence time and the worst overall survival (p < 0.001 and p < 0.001). Conclusions: our study demonstrated that recurrence with distant metastasis occurred earliest and had the worst outcome compared to regional or multiple intrahepatic recurrences.

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Section: Discussionmentioning

confidence: 99%

Recurrence Pattern Is an Independent Surgical Prognostic Factor for Long-Term Oncological Outcomes in Patients with Hepatocellular Carcinoma

Hsu,

Tang,

Huang

et al. 2024

Biomedicines

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“…The inclusion criteria were as follows: [ 1 ] cohort studies; [ 2 ] studies involving adult participants (aged ≥ 18 years); [ 3 ] studies clearly stating liver cancer as the outcome of interest; [ 4 ] studies providing explicit reports on the effect size of serum TC, TG, HDL-C, or LDL-C levels; and [ 5 ] studies reporting effect size measurements as hazard ratios (HRs) or relative risks (RRs) with corresponding 95% confidence intervals (95% CIs).…”

Section: Methodsmentioning

confidence: 99%

“…The exclusion criteria were as follows: [ 1 ] study design: studies with small sample sizes or significant selection bias; [ 2 ] age range: studies that did not cover the age range of the target participants; [ 3 ] outcome clarity: studies that did not explicitly state the study outcome or relevant indicators; [ 4 ] missing data: studies with substantial missing data or for which valid data could not be obtained; and [ 5 ] duplicate publications: studies that had been previously published in other literature.…”

Section: Methodsmentioning

confidence: 99%

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Association between blood lipid levels and the risk of liver cancer: a systematic review and meta-analysis

Zhang,

Xu,

Song

et al. 2024

Cancer Causes Control

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Purpose The association between blood lipid levels and the risk of developing liver cancer remains a subject of ongoing debate. To elucidate this association, we conducted a meta-analysis by systematically incorporating data from all relevant prospective cohort studies. Methods We conducted a systematic search of the PubMed, Embase, Web of Science, and Cochrane Library databases covering studies published from database inception through July 2023. This study included prospective cohort studies related to lipid profiles (e.g., total cholesterol (TC), triglyceride (TG), high-density lipoprotein cholesterol (HDL-C), and low-density lipoprotein cholesterol (LDL-C) levels) that reported hazard ratios (HRs) or relative risks (RRs) with corresponding 95% confidence intervals (95% CIs) to investigate their association with the risk of liver cancer. During the analysis process, we used fixed-effects or random-effects models based on the level of heterogeneity among the studies and obtained pooled risk ratios using these models. To ensure the robustness and reliability of the study findings, we also conducted sensitivity analyses and publication bias analyses. Results After conducting a systematic search, 12 studies were identified from a total of 11,904 articles and were included in the meta-analysis. These studies included a combined population of 10,765,221 participants, among whom 31,055 cases of liver cancer were reported. The analysis revealed that the pooled HR for the serum TC concentration (highest versus lowest) was 0.45 (95% CI = 0.35–0.58, I2 = 78%). For TGs, the HR was 0.67 (95% CI = 0.46–0.96, I2 = 86%), while for HDL-C, the HR was 0.72 (95% CI = 0.58–0.90, I2 = 65%). The HR for LDL-C was 0.51 (95% CI = 0.23–1.13, I2 = 93%). Conclusion The findings of this study indicate that serum TC, TG, and HDL-C levels are negatively associated with liver cancer risk, suggesting that higher concentrations of these lipids are associated with a reduced risk of liver cancer. However, no significant association has been found between LDL-C levels and liver cancer risk.

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“…Therefore, the poor long-term clinical prognosis of HCC poses a serious public health problem in countries around the world 14 . Therefore, it is particularly necessary to explore the underlying mechanisms of the development of NALFD, liver cirrhosis and HCC, as well as new therapeutic strategies.…”

Section: Introductionmentioning

confidence: 99%

Assessing the causal relationship between mitochondria-associated proteins and chronic liver diseases：a comprehensive Mendelian randomisation study

guo,

Ye,

Wang

et al. 2023

Preprint

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Mitochondria-related proteins (MRPs) and chronic liver diseases have been linked in various studies, although their causal relationship has not been elucidated. In this study, we investigated the causal associations between MRPs and non-alcoholic fatty liver disease (NALFD), liver cirrhosis and hepatocellular carcinoma (HCC) by two-sample bidirectional Mendelian randomisation(MR) analysis.The random-effect Inverse variance weighted (IVW) is the primary analysis for causality analysis while MR-Egger and Weighted Median (WM) as complementary analyses. Cochran Q test, MR-Egger intercept test, MR-PRESSO and leave-one-out analysis were used for sensitivity analyses. In addition, we performed bonferroni correction,multivariable MR analysis(MVMR),reverse causality detection and protein–protein interaction(PPI) network to enrich the results of this study.After rigorous genetic variant selection, IVW, sensitivity analysis, 3 genetically determined MRPs were significantly associated with NAFLD [MRPL33 (OR: 1.06, 95% CI: 1.00-1.11, p = 0.0284), MRPL34 (OR: 0.88, 95% CI: 0.78–0.98, p = 0.0294) and FARS2 (OR : 0.90, 95% CI: 0.84–0.97, p = 0.0120)], 2 MRPs were significantly associated with liver cirrhosis[MICU1 (OR: 1.11, 95% CI: 1.00-1.22, p = 0.0337) and NUDT8 (OR: 1.16, 95% CI: 1.03–1.30, p = 0.0096)], and 4 MRPs were significantly correlated with HCC [MRPL32 (OR: 0.62, 95% CI: 0.39–0.99, p = 0. 0492), MRPL33 (OR:1.29, 95% CI: 1.07–1.55, p = 0.0063), SCO1 (OR:0.56, 95% CI. 0.38–0.83, p = 0.0036) and SIRT5 (OR:0.71, 95% CI: 0.53–0.96, p = 0.0283)].Our findings provide a new perspective on the exploration of the underlying mechanisms of chronic liver diseases. However, further studies are still needed to explore the mechanisms of possible potential causal associations between MRPs and chronic liver diseases.

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Consensus on the tertiary prevention of primary liver cancer

Cited by 3 publications

References 96 publications

Recurrence Pattern Is an Independent Surgical Prognostic Factor for Long-Term Oncological Outcomes in Patients with Hepatocellular Carcinoma

Recurrence Pattern Is an Independent Surgical Prognostic Factor for Long-Term Oncological Outcomes in Patients with Hepatocellular Carcinoma

Association between blood lipid levels and the risk of liver cancer: a systematic review and meta-analysis

Assessing the causal relationship between mitochondria-associated proteins and chronic liver diseases：a comprehensive Mendelian randomisation study

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