Consensus on the Role of Antibiotic Use in SSI Following Spinal Surgery

Kepler, Christopher K.; Divi, Srikanth N.; Russo, Glenn S.; Segar, Anand; Boody, Barrett; Bronson, Wesley H.; Tarazona, Daniel; Cifuentes, Elizabeth; Asma, Ali; Galetta, Matthew S.; Goyal, Dhruv K.C.; Fang, Taolin; Schroeder, Gregory D.; Vaccaro, Alexander R.

doi:10.1097/bsd.0000000000000856

Cited by 2 publications

(1 citation statement)

References 100 publications

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“…The Second International Consensus Meeting (ICM) on Musculoskeletal Infection convened in July 2018 to discuss issues regarding infection in orthopaedic patients 43 . One subspecialty group that was focused on the spine recommended that the optimal prophylactic antibiotic be a first or second-generation cephalosporin given intravenously within 60 minutes prior to the first incision.…”

Section: Resultsmentioning

confidence: 99%

Current Guidelines and Practice Recommendations to Prevent Hospital-Acquired Conditions After Major Orthopaedic Surgeries

et al. 2022

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In 2016, a total of 48,771 hospital-acquired conditions (HACs) were reported in U.S. hospitals. These incidents resulted in an excess cost of >$2 billion, which translates to roughly $40,000 per patient with an HAC.Current guidelines for the prevention of venous thromboembolism and surgical site infection consist primarily of antithrombotic prophylaxis and antiseptic technique, respectively.The prevention of catheter-associated urinary tract infection (CA-UTI) and in-hospital falls and trauma is done best via education. In the case of CA-UTI, this consists of training staff about the indications for catheters and their timely removal when they are no longer necessary, and in the case of in-hospital falls and trauma, advising the patient and family about the patient’s fall risk and communicating the fall risk to the health-care team.Blood incompatibility is best prevented by implementation of a pretransfusion testing protocol. Pressure ulcers can be prevented via patient positioning, especially during surgery, and via postoperative skin checks.

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Section: Resultsmentioning

confidence: 99%

Current Guidelines and Practice Recommendations to Prevent Hospital-Acquired Conditions After Major Orthopaedic Surgeries

et al. 2022

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Infections after spine instrumentation: effectiveness of short antibiotic treatment in a large multicentre cohort

Benavent

Rodríguez-Pardo

Ulldemolins

et al. 2021

Journal of Antimicrobial Chemotherapy

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Background and objectives Available information about infection after spine instrumentation (IASI) and its management are scarce. We aimed to analyse DAIR (debridement, antibiotics and implant retention) prognosis and evaluate effectiveness of short antibiotic courses on early forms. Methods Multicentre retrospective study of patients with IASI managed surgically (January 2010–December 2016). Risk factors for failure were analysed by multivariate Cox regression and differences between short and long antibiotic treatment were evaluated with a propensity score-matched analysis. Results Of the 411 IASI cases, 300 (73%) presented in the first month after surgery, 48 in the second month, 22 in the third and 41 thereafter. Infections within the first 2 months (early cases) occurred mainly to older patients, with local inflammatory signs and predominance of Enterobacteriaceae, unlike those in the later periods. When managed with DAIR, prognosis of early cases was better than later ones (failure rate 10.4% versus 26.1%, respectively; P = 0.02). Risk factors for DAIR failure in early cases were female sex, Charlson Score, large fusions (>6 levels) and polymicrobial infections (adjusted HRs of 2.4, 1.3, 2.6 and 2.26, respectively). Propensity score matching proved shorter courses of antibiotics (4–6 weeks) as effective as longer courses (failure rates 11.4% and 10.5%, respectively; P = 0.870). Conclusions IASIs within the first 2 months could be managed effectively with DAIR and shorter antibiotic courses. Clinicians should be cautious when faced with patients with comorbidities, large fusions and/or polymicrobial infections.

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Consensus on the Role of Antibiotic Use in SSI Following Spinal Surgery

Cited by 2 publications

References 100 publications

Current Guidelines and Practice Recommendations to Prevent Hospital-Acquired Conditions After Major Orthopaedic Surgeries

Current Guidelines and Practice Recommendations to Prevent Hospital-Acquired Conditions After Major Orthopaedic Surgeries

Infections after spine instrumentation: effectiveness of short antibiotic treatment in a large multicentre cohort

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