Consenso de la Asociación Española de Urología en el diagnóstico y manejo del síndrome de dolor vesical

Esteban, M.; Adot, J.M.; Arlandis, Salvador; Peri, L.; Prieto, Luís; Salinas, J.; Cózar, J.M.

doi:10.1016/j.acuro.2015.01.006

Cited by 12 publications

(1 citation statement)

References 29 publications

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“…Analysis of urine specimens found higher concentration of immunoglobulin and inflammatory mediators. Our current understanding is that most IC/BPS patients in the population do not present with Hunner’s lesions and therefore are classed as having non-Hunner-type IC/BPS 19 . To date, bladder wall biopsy is the only available method to detect mast cells 20 and molecular signatures of chronic inflammation in the bladder wall, but the method is limited by invasiveness and potential complications.…”

Section: Current Understanding Of the Pathologymentioning

confidence: 99%

Recent advances in imaging and understanding interstitial cystitis

et al. 2018

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Interstitial cystitis/bladder pain syndrome (IC/BPS) is a debilitating condition associated with intense pelvic pain and bladder storage symptoms. Since diagnosis is difficult, prevalence estimates vary with the methodology used. There is also a lack of proven imaging tools and biomarkers to assist in differentiation of IC/BPS from other urinary disorders (overactive bladder, vulvodynia, endometriosis, and prostatitis). Current uncertainty regarding the etiology and pathology of IC/BPS ultimately impacts its timely and successful treatment, as well as hampers future drug development. This review will cover recent developments in imaging methods, such as magnetic resonance imaging, that advance the understanding of IC/BPS and guide drug development.

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Section: Current Understanding Of the Pathologymentioning

confidence: 99%

Recent advances in imaging and understanding interstitial cystitis

et al. 2018

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Molecular pathogenesis of interstitial cystitis/bladder pain syndrome based on gene expression

Karamali

Shafabakhsh

Ghanbari

et al. 2019

Journal Cellular Physiology

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Interstitial cystitis/painful bladder syndrome (IC/PBS) is a chronic bladder inflammation that leads to chronic bladder pain and urinary urgency and frequency. The presentation of IC/PBS is heterogeneous, and it is classified as ulcerative IC/PBS and nonulcerative IC/PBS. The main cause of IC/PBS is thought to be a persistent inflammatory condition in the bladder, though the actual pathophysiology has not been identified yet. Although the underlying pathophysiology of IC/PBS is not completely understood, several theories for the etiology of this syndrome have been suggested, including deficiency of the glycosaminoglycan covering urothelium surface that results in leaky urothelium infection, immunological etiology, activated mast cells, neural changes, and inflammation. In addition, there are no gold standards for the detection of this disorder to date. So, determination of gene expression and its role in different signaling pathways in the pathogenesis of this heterogeneous disorder contribute to the more efficient cognition of the pathophysiology of this disease and to the design of effective treatments and molecular diagnostic methods for IC/PBS.

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Diet Therapy in the Context of Chronic Pelvic Pain

Shorter

Gordon

2017

Urological and Gynaecological Chronic Pelvic Pain

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Consenso de la Asociación Española de Urología en el diagnóstico y manejo del síndrome de dolor vesical

Cited by 12 publications

References 29 publications

Recent advances in imaging and understanding interstitial cystitis

Recent advances in imaging and understanding interstitial cystitis

Molecular pathogenesis of interstitial cystitis/bladder pain syndrome based on gene expression

Diet Therapy in the Context of Chronic Pelvic Pain

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