Consecutive lipase immobilization and glycerol carbonate production under continuous-flow conditions

Leão, Raquel A. C.; Souza, Stefânia P. de; Nogueira, Daniel O.; Silva, Guilherme M. A.; Silva, Marcus V. M.; Gutarra, Melissa Limoeiro Estrada; Miranda, Leandro S. M.; Castro, Aline Machado de; Itabaiana, Ivaldo; Souza, Rodrigo O. M. A. de

doi:10.1039/c6cy00295a

Cited by 36 publications

(24 citation statements)

References 46 publications

(44 reference statements)

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“…Given the interest of the process, supercritical conditions [215][216][217][218][219][220][221][222] or the use of different lipases [223][224][225][226][227][228][229][230][231][232][233][234][235][236][237][238][239] have also been studied. DMC has been recently investigated in regards to the synthesis of fatty acid methyl esters via ionic liquids [240,241] or non-catalytic transesterification of vegetable oils with dimethyl carbonate and some amounts of silica loading operating as a dispersing agent [242]. [194].…”

Section: Biodiesel-like Biofuels That Integrate the Glycerol As Glycementioning

confidence: 99%

Biodiesel at the Crossroads: A Critical Review

et al. 2019

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The delay in the energy transition, focused in the replacement of fossil diesel with biodiesel, is mainly caused by the need of reducing the costs associated to the transesterification reaction of vegetable oils with methanol. This reaction, on an industrial scale, presents several problems associated with the glycerol generated during the process. The costs to eliminate this glycerol have to be added to the implicit cost of using seed oil as raw material. Recently, several alternative methods to convert vegetable oils into high quality diesel fuels, which avoid the glycerol generation, are being under development, such as Gliperol, DMC-Biod, or Ecodiesel. Besides, there are renewable diesel fuels known as “green diesel”, obtained by several catalytic processes (cracking or pyrolysis, hydrodeoxygenation and hydrotreating) of vegetable oils and which exhibit a lot of similarities with fossil fuels. Likewise, it has also been addressed as a novel strategy, the use of straight vegetable oils in blends with various plant-based sources such as alcohols, vegetable oils, and several organic compounds that are renewable and biodegradable. These plant-based sources are capable of achieving the effective reduction of the viscosity of the blends, allowing their use in combustion ignition engines. The aim of this review is to evaluate the real possibilities that conventional biodiesel has in order to success as the main biofuel for the energy transition, as well as the use of alternative biofuels that can take part in the energy transition in a successful way.

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Section: Biodiesel-like Biofuels That Integrate the Glycerol As Glycementioning

confidence: 99%

Biodiesel at the Crossroads: A Critical Review

et al. 2019

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“…Moreover, the strong shear forces and attrition experienced in a stirred tank reactor can also shorten the lifetime of an immobilised enzyme, and so a packed bed reactor represents more attractive alternative for long-term manufacturing. The use of immobilised lipase enzymes in continuous flow has been well documented and has been shown to increase productivity and reduce reaction times [30][31][32] . Herein we present several biocatalytic approaches towards the target compound ester (1R, 2R)-3 employing different enzyme systems.…”

Section: Methodsmentioning

confidence: 99%

Comparison of a Batch and Flow Approach for the Lipase-Catalyzed Resolution of a Cyclopropanecarboxylate Ester, A Key Building Block for the Synthesis of Ticagrelor

Hugentobler

Rasparini²,

Thompson

et al. 2017

Org. Process Res. Dev.

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In this study a batch reactor process is compared to a flow chemistry approach for lipase catalysed resolution of the cyclopropyl ester (±)-3. (1R, 2R)-3 is a precursor of the amine (1R, 2S)-2 which is a key building block of the API ticagrelor. For both flow and batch operation, the biocatalyst could be recycled several times, whereas in the case of the flow process the reaction time was significantly reduced.2

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“…18 Therefore, it is necessary to seek inexpensive industrial materials to develop highly active, easily reusable and non-toxic heterogeneous catalysts. 19 ________________________________________________________________________________________________________________________ Available on line at www.shd.org.rs/JSCS/ (CC) 2019 SCS.…”

Section: Introductionmentioning

confidence: 99%

Water glass derived catalyst for the synthesis of glycerol carbonate via the transesterification reaction between glycerol and dimethyl carbonate

Wang

Okoye

et al. 2019

JSCS

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Water glasses with different modulus (mole ratio of SiO 2 to Na 2 O) were applied as a raw material to prepare five solid base catalysts for the synthesis of glycerol carbonate (GC) by the transesterification reaction between glycerol and dimethyl carbonate (DMC). The structure and properties of the five water glass-derived catalysts were investigated by XRD, FT-IR, FESEM, BET and acid-base titration methods. The catalysts with relatively low modulus, including 1.0, 1.5 and 2.0, presented good catalytic abilities, among which the catalyst derived from water glass with 2.0 modulus (WG-2.0) was chosen as the optimal catalyst in the synthesis of GC. This was because WG--2.0 showed the highest BET surface area, relatively high total basicity, and needed a less amount of NaOH during the preparation process. In the optimization experiments, this catalyst exhibited good catalytic ability with the glycerol conversion of 96.3 % and GC yield of 94.1 % under the condition of glycerol to DMC mole ratio of 1:4, WG-2.0 amount of 4 wt. %, reaction temperature of 348 K and reaction time of 90 min. Furthermore, the reusability experiment of WG-2.0 was also conducted and the results indicated that WG--2.0 could be reused five times without significant reduction in its catalytic ability.

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Consecutive lipase immobilization and glycerol carbonate production under continuous-flow conditions

Abstract: Several value-added products can be produced from glycerol and among these products glycerol carbonate (GC) has received much attention in recent years because of its physical properties and wide application in the chemical, pharmaceutical and food industries.

Cited by 36 publications

References 46 publications

Biodiesel at the Crossroads: A Critical Review

Biodiesel at the Crossroads: A Critical Review

Comparison of a Batch and Flow Approach for the Lipase-Catalyzed Resolution of a Cyclopropanecarboxylate Ester, A Key Building Block for the Synthesis of Ticagrelor

Water glass derived catalyst for the synthesis of glycerol carbonate via the transesterification reaction between glycerol and dimethyl carbonate

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