Consecuencias de la infección malárica gestacional en la función inmune y en la inmunomodulación de la madre y el neonato

Álvarez-Larrotta, Catalina; Carmona‐Fonseca, Jaime

doi:10.4067/s0716-10182019000300341

Cited by 3 publications

(3 citation statements)

References 59 publications

(78 reference statements)

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“…Es imprescindible tomar en consideración que las respuestas inmunológicas generadas por Plasmodium spp. dependen de la variabilidad antigénica de la cepa parasitaria; su genotipo y fenotipo; el tipo de antígeno reconocido por los receptores de las células presentadoras de antígeno; y el tipo de receptor que reconoce dicho antígeno, como los tipos Toll, basureros, Fcγ o de complemento (45).…”

Section: Epidemiologíaunclassified

“…Por lo tanto, bajas concentraciones de IL-10, asociadas a altas concentraciones de IL-17, se relacionan con bajo peso fetal. También se ha evidenciado que bajos niveles de IL-5 se asocian a mayor riesgo de presentar partos pretérmino y neonatos pequeños para su edad gestacional (43,45,46). Esta tormenta de citoquinas provoca desórdenes en el transporte de aminoácidos y glucosa, así como en la expresión y distribución de las moléculas transportadoras de nutrientes y hormonas de crecimiento (34,42).…”

Section: Epidemiologíaunclassified

“…Por último, es preponderante tomar en consideración que la mayoría de las infecciones maláricas asociadas al embarazo en países endémicos, son submicroscópicas (45,75,76). Las monoinfecciones submicroscópicas por P. falciparum se asocian a mayores índices de anemia materna.…”

Section: Manifestaciones Clínicas Y Complicaciones Maternofetalesunclassified

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Malaria asociada al embarazo: revisión narrativa

Núñez-Troconis¹,

Ruiz²,

Núñez³

2023

RSOGV

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Malaria infections increase the risk of complications in the mother-fetus binomial. In Venezuela, the casuistry of this vulnerable group has not been updated in recent years. The objective of this narrative review was to comprehensively describe what pregnancy-associated malaria is and its maternal, fetal and neonatal effects; trying to answer the following research question. All forms of pregnancy-associated malaria, including gestational, placental and congenital malaria, cause maternal-fetal and neonatal alterations that, if they progress, could lead to the death of this binomial. Physiopathology and immunopathology can explain the symptoms of pregnant women and the fetus, as well as their complications; depending on the parasitic form affecting. There are new updates in the diagnosis, prevention and treatment of this entity.

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Section: Epidemiologíaunclassified

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Malaria asociada al embarazo: revisión narrativa

Núñez-Troconis¹,

Ruiz²,

Núñez³

2023

RSOGV

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Predictors of knowledge and use of long-lasting insecticidal nets for the prevention of malaria among the pregnant women in Pakistan

Kumar

Farzeen

Ahmed

et al. 2021

Malar J

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Background Malaria is endemic to Pakistan with high prevalence among pregnant women and linked with maternal anaemia, intrauterine growth retardation, preterm birth, and low birth weight. The use of long-lasting insecticidal nets (LLINs) is a proven and cost-effective intervention preventing malaria among pregnant women. The present study aimed to explore predictors of knowledge and use of LLINs among pregnant women in Pakistan. Methods This was part of a quasi-experimental study of 200 pregnant women conducted in a rural district of Sindh province in Pakistan. Data were collected using Malaria Indicator Survey questionnaires developed by Roll Back Malaria Partnership to end Malaria Monitoring and Evaluation Reference Group. Pregnant women and mothers with newborns of six months of age were interviewed in their homes. Results The age of the women was from 18 to 45, two thirds of the respondents (72.5%) were uneducated and married (77%). Majority (92%) of the women had received antenatal care during pregnancy, and 29.5% women had received counseling on malaria during their antenatal care visits. Multiple linear regression showed that the type of latrine was the most significant (β = 0.285, p < 0.001) determinant of knowledge about malaria among pregnant women followed by the death of a newborn (β = 0.271, p < 0.001). The use of mobile phone was the most significant (β = 0.247, p < 0.001) predictor of usage of LLINs among pregnant women followed by the death of a newborn (β = 0.232, p < 0.05). Conclusions Maternal education, type of latrine, use of mobile phone, malaria during previous pregnancy and newborn death were strong predictors of knowledge and use of LLINs in pregnant women in Pakistan. There is a need to scale-up programmes that aim to create awareness regarding malaria among pregnant women. Mobile phone technology can be used to implement awareness programmes focusing on malaria prevention among women.

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Malaria and pregnancy: a Venezuelan approach. Review article

Ruiz¹,

Núñez²,

Martín-Castelli³

et al. 2022

OGIJ

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Aim: to review and describe exhaustively the implications of malaria in pregnancy, including its maternal, fetal, and neonatal clinical manifestations and effects; immunopathology and pathophysiology; advancements in its diagnostics, histopathology, and treatment options; and epidemiology, particularly in Venezuela, a country where its data is almost non-existent. Methods: the information used to write this manuscript was obtained during a three-month period, between June and September 2022, from specialized literature, written in English and Spanish, related to malaria associated with pregnancy, mainly published during the last five years, using journals found in the most relevant medical digital archives, including PubMed, SciELO, Elsevier, Google Scholar, Latindex, and Cochrane Plus. Among the keywords used for obtaining this updated information were malaria; malaria in pregnancy; gestational malaria; placental malaria; congenital malaria. Results: all the clinical forms related to malaria in pregnancy, including gestational, placental, and congenital malaria, can cause maternal-fetal alterations, that, in case of progressing, could lead to the death of this binomial. Their pathophysiology and immunopathology can explain the gestational and fetal symptomatology, as well as their complications, depending on the parasite form that affected them. There are new updates regarding the diagnostics, prevention, and treatment of this medical entity. Conclusion: it is imperative to exalt the relevance of studying this disease in pregnant patients, especially in the Venezuelan topography, a focus of infection with a plethora of cases of said entity, whose lack of updated epidemiological data, regarding its prevalence and incidence, is profoundly preoccupying. Pregnant patients are not only one of the most vulnerable risk groups of this parasitosis, but also have the capacity of duplicating the risk of infecting the fetus.

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Consecuencias de la infección malárica gestacional en la función inmune y en la inmunomodulación de la madre y el neonato

Abstract: Los autores declaramos que no hay conflicto de intereses.

Cited by 3 publications

References 59 publications

Malaria asociada al embarazo: revisión narrativa

Malaria asociada al embarazo: revisión narrativa

Predictors of knowledge and use of long-lasting insecticidal nets for the prevention of malaria among the pregnant women in Pakistan

Malaria and pregnancy: a Venezuelan approach. Review article

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