Connexins in Cancer, the Possible Role of Connexin46 as a Cancer Stem Cell-Determining Protein
Isidora M. León-Fuentes,
María G. Salgado-Gil,
María S. Novoa
et al.
Abstract:Cancer is a widespread and incurable disease caused by genetic mutations, leading to uncontrolled cell proliferation and metastasis. Connexins (Cx) are transmembrane proteins that facilitate intercellular communication via hemichannels and gap junction channels. Among them, Cx46 is found mostly in the eye lens. However, in pathological conditions, Cx46 has been observed in various types of cancers, such as glioblastoma, melanoma, and breast cancer. It has been demonstrated that elevated Cx46 levels in breast c… Show more
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