Connexin32 ameliorates epithelial-to-mesenchymal-transition in diabetic renal tubular via inhibiting NOX4

Sun, Xiaohong; Xiao, Haipeng; Li, Shanshan; Chen, Rui; Lin, Zhiyuan; Yang, Yan; Chen, Zhiquan; Deng, Li; Huang, Heqing

doi:10.1016/j.phrs.2022.106084

Cited by 3 publications

(1 citation statement)

References 56 publications

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“…Renal tubulointerstitial fibrosis, characterized by EMT of renal tubular epithelial cells (RTEC), is a major cause of diabetic renal fibrosis ( 56 ). Important roles of different tubular responses, such as partial EMT, cell cycle arrest and metabolic defects are involved in renal fibrosis ( 57 ).…”

Section: Stem Cell Products Ameliorate Fibrosis In Renal Tubular Epit...mentioning

confidence: 99%

An overview of the efficacy and signaling pathways activated by stem cell-derived extracellular vesicles in diabetic kidney disease

et al. 2022

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Diabetic kidney disease (DKD) is one of complications of diabetes mellitus with severe microvascular lesion and the most common cause of end-stage chronic kidney disease (ESRD). Controlling serum glucose remains the primary approach to preventing and slowing the progression of DKD. Despite considerable efforts to control diabetes, people with diabetes develop not only DKD but also ESRD. The pathogenesis of DKD is very complex, and current studies indicate that mesenchymal stromal cells (MSCs) regulate complex disease processes by promoting pro-regenerative mechanisms and inhibiting multiple pathogenic pathways. Extracellular vesicles (EVs) are products of MSCs. Current data indicate that MSC-EVs-based interventions not only protect renal cells, including renal tubular epithelial cells, podocytes and mesangial cells, but also improve renal function and reduce damage in diabetic animals. As an increasing number of clinical studies have confirmed, MSC-EVs may be an effective way to treat DKD. This review explores the potential efficacy and signaling pathways of MSC-EVs in the treatment of DKD.

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Section: Stem Cell Products Ameliorate Fibrosis In Renal Tubular Epit...mentioning

confidence: 99%

An overview of the efficacy and signaling pathways activated by stem cell-derived extracellular vesicles in diabetic kidney disease

et al. 2022

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Genome-wide identification of gap junction (connexins and pannexins) genes in black rockfish (Sebastes schlegelii): Evolution and immune response mechanism following challenge

Liu

Cao

et al. 2023

Fish & Shellfish Immunology

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Connexin32 Promotes the Activation of Foxo3a to Ameliorate Diabetic Nephropathy via Inhibiting the Polyubiquitination and Degradation of Sirt1

Xiao

Sun

et al. 2023

Antioxidants & Redox Signaling

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Connexin32 ameliorates epithelial-to-mesenchymal-transition in diabetic renal tubular via inhibiting NOX4

Cited by 3 publications

References 56 publications

An overview of the efficacy and signaling pathways activated by stem cell-derived extracellular vesicles in diabetic kidney disease

An overview of the efficacy and signaling pathways activated by stem cell-derived extracellular vesicles in diabetic kidney disease

Genome-wide identification of gap junction (connexins and pannexins) genes in black rockfish (Sebastes schlegelii): Evolution and immune response mechanism following challenge

Connexin32 Promotes the Activation of Foxo3a to Ameliorate Diabetic Nephropathy via Inhibiting the Polyubiquitination and Degradation of Sirt1

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