Connexin 43 expression in human brain glial tumors

Abstract

The low connexin 43 expression levels may reflect both a reduction in astroglial functional gap junctions and semicanals and a decrease in the amount of the protein itself that has independently antioncogenic properties. The observed cytoplasmic and nuclear expression of connexin 43 is most likely to be associated with the aberrant activity of a number of kinases, such as proto-oncogene tyrosine-kinase Src or protein kinase C (PKC).

Calretinin and calbindin architecture of the midline thalamus associated with prefrontal–hippocampal circuitry

“…We also observed dense PV + fibers and puncta throughout much of the nearby lateral thalamus and striatum. In TRN, we saw uniformly dense populations of PV + cells with large immunonegative nuclei, which is characteristic of PV + labeling in TRN neurons (Fig 1D; (Arai et al, 1994;Celio, 1990;Csillik et al, 2005;Kirichenko et al, 2017). Likewise, the distribution of PV + cells in cortex was organized by layers and was comparatively more sparse (Fig 1E; also see Van Brederode et al, 1991;Ahn et al, 2017).…”