Connexin 32 and 43 mutations: Do they play a role in chronic rhinosinusitis?

Sedaghat, Ahmad R.; Cunningham, Michael J.; Busaba, Nicholas Y.

doi:10.1016/j.amjoto.2013.08.008

Cited by 2 publications

(2 citation statements)

References 24 publications

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“…Cx26 was identified in human fetal tissue, and Cx43 in whole nasal tissue . Mutations of some connexin channels have been investigated as a potential cause for dysfunction of sinonasal epithelium, but were found to be rare . Other research examining the potential role of connexin gap junctions in the rhinologic literature include a group that reported suppressed Cx26 levels in primary human nasal epithelial cells of patients with allergic rhinitis, and concluded that aeroallergens may have a direct effect on the suppression .…”

Section: Discussionmentioning

confidence: 99%

Connexin gap junction channels and chronic rhinosinusitis

Kim

Chang

et al. 2016

Int Forum Allergy Rhinol

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Section: Discussionmentioning

confidence: 99%

Connexin gap junction channels and chronic rhinosinusitis

Kim

Chang

et al. 2016

Int Forum Allergy Rhinol

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“…A recent report revealed that 16 connexin genes are expressed in the human sinus mucosa [ 3 ]. One report found that connexin-43 is significantly upregulated in CRS patients compared to healthy controls at both the mRNA and protein levels, whereas other reports searching for a potential cause of dysfunction in the sinonasal epithelium failed to find a significant difference in the expressions of connexin-26, -30, -32, or -43 [ 3 – 5 ]. Although the relationship between CRS and connexin expression is still controversial, those reports have consistently shown that connexin-43 is expressed in human nasal epithelial cells.…”

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confidence: 99%

Synchronized roles of pannexin and connexin in nasal mucosal epithelia

Ohbuchi

Suzuki

2018

Eur Arch Otorhinolaryngol

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BackgroundNasal mucosal epithelial cells express connexins, the prototypical gap junction proteins, and pannexins, a new family of channel proteins homologous to the invertebrate gap junction proteins. The physiological and pathophysiological roles of these transmembrane proteins in nasal mucosa are largely still unknown.PurposePannexins participate in ATP release into the extracellular space in various tissues, and ATP plays important roles in mucociliary clearance, especially by regulating ciliary beat activity. Therefore, we focused on the functional relationship between connexins, pannexin-1, ATP release, and mucociliary clearance in nasal epithelia.Results and ConclusionsConnexins participate in the generation of intercellular calcium waves, in which calcium-mediated signaling responses spread to contiguous cells through the gap junction formed by connexins to transmit calcium signaling throughout the airway epithelium. Pannexins in the nasal mucosa may contribute to not only ciliary beat modulation via ATP release, but also regulation of mucus blanket components via H2O efflux. The synchronized roles of pannexin and connexin may provide a new insight into effective mucociliary clearance systems in nasal mucosa.

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Connexin 32 and 43 mutations: Do they play a role in chronic rhinosinusitis?

Cited by 2 publications

References 24 publications

Connexin gap junction channels and chronic rhinosinusitis

Connexin gap junction channels and chronic rhinosinusitis

Synchronized roles of pannexin and connexin in nasal mucosal epithelia

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