Connectivity model of the anatomic substrates and network abnormalities in major depressive disorder: A coordinate meta-analysis of resting-state functional connectivity

Personalized, parcel‐guided rTMS for the treatment of major depressive disorder: Safety and proof of concept

“…Nevertheless, L8Av (within the dlPFC) and LPGs (outside of the dlPFC) were the most common targets shared by these patients. These two areas of the DMN were also common targets in the treatment of anxiety (Young, Taylor, et al, 2023). These results highlight the importance of personalized rTMS, which will account for individualized connectivity differences in treatment regiments.…”

“…Most of our patients had rTMS targets outside of the dlPFC. In previous studies, we have shown that the use of connectome-guided rTMS can induce neuroplasticity and alter functional connectivity (Yeung et al, 2021;Young, Taylor, et al, 2023). Therefore, it is likely that the effects of rTMS will remain with the patient for the long term, but longer follow-up is warranted to determine if this holds true.…”

“…The Infinitome software was used as previously described (Poologaindran et al, 2022;Yeung et al, 2021;Young, Taylor, et al, 2023). Below are the brief technical summaries involved in image processing.…”

“…To determine the normal range of correlations for each functional connectivity pair in the matrix, outlier detection was performed using a tangent space connectivity matrix; the results obtained were compared against the tangent space connectivity transformation of 200 normal subject rsfMRI samples collected from healthy controls from the OpenNeuro (https://openneuro.org/) and SchizConnect (http://schizconnect.org) datasets. To reduce the false discovery rate, abnormal connectivity from rsfMRI was determined as a threesigma outlier for that correlation after excluding the highest variance 1/3 of pairs (Poologaindran et al, 2022;Tang et al, 2022;Young, Taylor, et al, 2023).…”

“…Finally, there were no adverse effects associated with the rTMS treatment. We have previously reported the use of this personalized rTMS method in numerous studies (Dadario et al, 2022;Young, Taylor, et al, 2023;Poologaindran et al, 2022;Yeung et al, 2021), and it has been shown to be safe and able to effectively target multiple ROIs. In the original clinical trials for rTMS, scalp discomfort was identified as the 2007).…”