Connectivity-based segmentation of the striatum in Huntington's disease: Vulnerability of motor pathways

Bohanna, India; Georgiou‐Karistianis, Nellie; Egan, Gary F.

doi:10.1016/j.nbd.2011.02.010

Cited by 82 publications

(82 citation statements)

References 34 publications

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“…[26][27][28] Recent studies by using fMRI, FDG-PET, and DTI have provided in vivo evidence that supports this connectivity-based parcellation of the striatum. [29][30][31][32][33][34] In this study, damage to the OFC, PFC, and motor/premotor cortices caused reduced diffusion in the anterior, central, and posterior portion of the striatum (types 1, 2, and 3), respectively. These results were consistent with the anatomy of striatocortical connections and strongly suggested that the reduced diffusion observed here represented the early phase of secondary neuronal degeneration.…”

Section: Discussionmentioning

confidence: 60%

Postoperative Transient Reduced Diffusion in the Ipsilateral Striatum and Thalamus

Kamiya

Sato²,

Nakata³

et al. 2012

AJNR Am J Neuroradiol

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Section: Discussionmentioning

confidence: 60%

Postoperative Transient Reduced Diffusion in the Ipsilateral Striatum and Thalamus

Kamiya

Sato²,

Nakata³

et al. 2012

AJNR Am J Neuroradiol

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“…However, we note that probabilistic tractography thresholds takes into account erroneous fibers in a manner similar to that of exclusion criteria when using a streamline tractography approach. Thus we, as well as others using probabilistic tractography for thalamo-cortical connection investigation, 19,58,62,63 find the use of exclusion ROI unnecessary.…”

Section: Limitationsmentioning

confidence: 82%

Altered Thalamo-Cortical White Matter Connectivity: Probabilistic Tractography Study in Clinical-High Risk for Psychosis and First-Episode Psychosis

Cho

Shenton

Kubicki

et al. 2015

SCHBUL

105

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Disrupted thalamo-cortical connectivity is regarded as a core psychopathology in patients diagnosed with schizophrenia. However, whether the thalamo-cortical white matter connectivity is disrupted before the onset of psychosis is still unknown. To determine this gap in knowledge, the strength of thalamo-cortical white matter anatomical connectivity in subjects at clinical-high risk for psychosis (CHR) was compared to that of first-episode psychosis (FEP) and healthy controls. A total of 37 CHR, 21 FEP, and 37 matched healthy controls underwent diffusion-weighted magnetic resonance imaging to examine the number of probabilistic tractography "counts" representing thalamo-cortical white matter connectivity. We also investigated the relationship with psychopathology. For FEP, the connectivity between the thalamus and parietal cortex was significantly increased (F = 5.65, P < .05) compared to that of healthy controls. However, the connectivity between thalamus and orbitofrontal cortex was significantly reduced compared to both healthy controls (F = 11.86, P < .005) and CHR (F = 6.63, P < .05). Interestingly, CHR exhibited a similar pattern as FEP, albeit with slightly reduced magnitude. Compared to healthy controls, there was a significant decrease (F = 4.16, P < .05) in CHR thalamo-orbitofrontal connectivity. Also, the strength of the thalamo-orbitofrontal connectivity was correlated with the Global Assessment of Functioning score in CHR (r = .35, P < .05). This observed pattern of white matter connectivity disruptions in FEP and in CHR suggests that this pattern of disconnectivity not only highlights the involvement of thalamus but also might be useful as an early biomarker for psychosis.

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“…The executive control network also showed impaired synchronization with the putamen and superior parietal area. Postmortem and imaging studies have shown significant neurodegeneration of the posterior putamen in patients with Huntington disease, [57][58][59] with the ventral anterior portion rela tively spared. 60 Our findings suggest that this focal neuro degeneration may result in a functional disconnection of the corticostriatal cognitive loop from the frontal executive system of the cerebral cortex.…”

Section: Discussionmentioning

confidence: 99%

Abnormal synchrony of resting state networks in premanifest and symptomatic Huntington disease: the IMAGE-HD study

Poudel

Egan

Churchyard

et al. 2014

J Psychiatry Neurosci

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Connectivity-based segmentation of the striatum in Huntington's disease: Vulnerability of motor pathways

Cited by 82 publications

References 34 publications

Postoperative Transient Reduced Diffusion in the Ipsilateral Striatum and Thalamus

Postoperative Transient Reduced Diffusion in the Ipsilateral Striatum and Thalamus

Altered Thalamo-Cortical White Matter Connectivity: Probabilistic Tractography Study in Clinical-High Risk for Psychosis and First-Episode Psychosis

Abnormal synchrony of resting state networks in premanifest and symptomatic Huntington disease: the IMAGE-HD study

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