“…The fronto-polar cortex (BA 10) -a structurally and functionally heterogeneous region (Kringelbach and Rolls, 2004;Gilbert et al, 2010a) has been consistently subdivided based on cytoarchitectonic features, on anatomical and functional resting state connectivity patterns, and on meta-analyses of fMRI activation experiments, in two distinct interconnected subdivisions -a medial one as part of a network underlying affective processing and social cognition and a lateral one implicated in working memory, cognition and perception (Blundau et al, 2014;Moayedi et al, 2014;Kringelbach and Rolls 2004;Gilbert et al, 2006;Gilbert et al, 2010). Some studies distinguished three subdomains (Ongür et al, 2003;Liu H. et al 2013; although less evident in some subjects, see Moayedi et al, 2014), the medial part being further subdivided (Liu H. et al, 2013) in the orbital region (FPo) showing greater connection probability to social-emotional network (OFC, temporal pole, amygdala) and more medial part (FPm) showing stronger connection with midline regions of the default mode network (ACC, PCC/precuneus, MPFC) involved in internally focused tasks such as self-referential thought (Gusnard et al, 2001) and autobiographical memory retrieval and prospecting the future (Schacter et al, 2007). The meta-analysis showed that high NE-trait individuals tend to exhibit a lower GM within the medial OFC part overlapping mainly the above-mentioned orbital subdivision and increased GM in the left amygdala/ anterior parahippocampal regions (i.e.…”