Connectivity and synaptic features of hilar mossy cells and their effects on granule cell activity along the hippocampal longitudinal axis

Abdulmajeed, Wahab Imam; Wang, Kai Yi; Wu, Jei‐Wei; Ajibola, Musa Iyiola; Cheng, Irene Han‐Juo; Lien, Cheng Chang

doi:10.1113/jp282804

Cited by 3 publications

(11 citation statements)

References 61 publications

(141 reference statements)

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“…The activation of ventral MCs suppressed the spiking of ventral GCs (see Fig. 2 A and B of the paper by Abdulmajeed et al., 2022), whereas ventral (local) INs or dorsal (distal) GCs and INs increased their firing rate. This suggested a differential effect of ventral MC activation on ventral and dorsal GCs.…”

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confidence: 79%

“…In a recent article in The Journal of Physiology , Abdulmajeed et al. (2022) coupled optogenetics and electrophysiology to investigate the functional impact of MCs on dentate GCs along the longitudinal axis of the hippocampus. To this end, the authors performed unilateral injections of Cre‐dependent adeno‐associated virus type 5 into the hilus of the ventral DG of calcitonin receptor‐like receptor (Crlr‐Cre) mice.…”

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confidence: 99%

“…Abdulmajeed et al. (2022) also made field potential recordings in ventral and dorsal slices to test the effect of ventral MC axons on GC responses to activation of perforant pathway axons from the entorhinal cortex, the main cortical input to GCs. The population spike area from GCs was reduced when MC axons were activated in ventral slices before perforant pathway stimulation, suggesting the activation of an inhibitory conductance in ventral GCs.…”

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confidence: 99%

“…After showing that MCs and their axons could be activated readily by flashing blue light both in vivo and in vitro , Abdulmajeed et al. (2022) performed in vivo juxtacellular recordings of both GCs and INs located in the ventral (local) or dorsal (distal) DG while illuminating ChR2‐eYFP‐expressing axons from ventral MCs. The activation of ventral MCs suppressed the spiking of ventral GCs (see Fig.…”

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confidence: 99%

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Beyond the trisynaptic circuit: hilar mossy cells orchestrate the longitudinal control of dentate granule cell activity

Mateos‐Aparicio

2022

The Journal of Physiology

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confidence: 79%

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confidence: 99%

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confidence: 99%

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confidence: 99%

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Beyond the trisynaptic circuit: hilar mossy cells orchestrate the longitudinal control of dentate granule cell activity

Mateos‐Aparicio

2022

The Journal of Physiology

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“…The distinct physiological functions of MCs and CA3PCs are not surprising owing to some of their distinct morphologic, cellular and network organizational properties ( Scharfman, 2016 ). Notably, in contrast to the recurrent network between CA3PCs, the main output of MCs is an excitatory feedback to DG granule cells, which extends the entire axis of both ipsilateral and contralateral hippocampi ( Frotscher et al, 1991 ; Scharfman, 2016 ; Abdulmajeed et al, 2022 ). Thus, CA3PCs and MCs exert excitatory effects on distinct neuronal populations and the origin of some of their synaptic inputs is also different.…”

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confidence: 99%

Similar Presynaptic Action Potential-Calcium Influx Coupling in Two Types of Large Mossy Fiber Terminals Innervating CA3 Pyramidal Cells and Hilar Mossy Cells

Marosi

Arszovszki

Brunner

et al. 2023

eNeuro

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Morphologically similar axon boutons form synaptic contacts with diverse types of postsynaptic cells. However, it is less known to what extent the local axonal excitability, presynaptic action potentials and AP-evoked calcium influx contribute to the functional diversity of synapses and neuronal activity. This is particularly interesting in synapses that contact cell types that show only subtle cellular differences but fulfill completely different physiological functions. Here we tested these questions in two synapses that are formed by rat hippocampal granule cells onto hilar mossy cells and CA3 pyramidal cells, which albeit share several morphological and synaptic properties but contribute to distinct physiological functions. We were interested in the deterministic steps of the action potential-calcium ion influx coupling as these complex modules may underlie the functional segregation between and within the two cell types. Our systematic comparison using direct axonal recordings showed that AP shapes, Ca2+currents and their plasticity are indistinguishable in synapses onto these two cell types. These suggest that the complete module that couples granule cell activity to synaptic release is shared by hilar mossy cells and CA3 pyramidal cells. Thus, our findings present an outstanding example for the modular composition of distinct cell types, by which cells employ different components only for those functions that are deterministic for their specialized functions, while many of their main properties are shared.Significance statementHow different neurons should be for distinct functionality? Several examples showed that distinct neuron types use identical ion channels or synaptic proteins in various combinations to achieve cell type-specific excitability or synaptic properties. But what about complete modules, in which mechanisms cooperate for fundamental functions, such as the AP-ICacoupling that translates presynaptic activity to Ca2+influx that triggers synaptic release. Do cell type-specific functions determine the operation of modules? Here we examined AP-ICacoupling in the common synaptic drive to CA3 pyramidal cells and hilar mossy cells, which contribute to distinct hippocampal functions. We revealed that their main excitatory synapses from granule cells share all components of AP-ICacoupling, demonstrating that distinct cell types can utilize identical synaptic modules.

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Comparative Anatomy of the Dentate Mossy Cells in Nonhuman Primates: Their Spatial Distributions and Axonal Projections Compared With Mouse Mossy Cells

Jeong,

Won,

Lim

et al. 2024

eNeuro

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Glutamatergic mossy cells (MCs) mediate associational and commissural connectivity, exhibiting significant heterogeneity along the septotemporal axis of the mouse dentate gyrus (DG). However, it remains unclear whether the neuronal features of MCs are conserved across mammals. This study compares the neuroanatomy of MCs in the DG of mice and monkeys. The MC marker, calretinin, distinguishes two subpopulations: septal and temporal. Dual-colored fluorescence labeling is utilized to compare the axonal projection patterns of these subpopulations. In both mice and monkeys, septal and temporal MCs project axons across the longitudinal axis of the ipsilateral DG, indicating conserved associational projections. However, unlike in mice, no MC subpopulations in monkeys make commissural projections to the contralateral DG. In monkeys, temporal MCs send associational fibers exclusively to the inner molecular layer, while septal MCs give rise to wide axonal projections spanning multiple molecular layers, akin to equivalent MC subpopulations in mice. Despite conserved septotemporal heterogeneity, interspecies differences are observed in the topological organization of septal MCs, particularly in the relative axonal density in each molecular layer along the septotemporal axis of the DG. In summary, this comparative analysis sheds light on both conserved and divergent features of MCs in the DG of mice and monkeys. These findings have implications for understanding functional differentiation along the septotemporal axis of the DG and contribute to our knowledge of the anatomical evolution of the DG circuit in mammals.Significance StatementThis study investigates glutamatergic mossy cells (MCs) in the dentate gyrus (DG) of mice and monkeys, revealing both conserved and species-specific features. While associational projections are consistent across species, monkeys lack the commissural projections of MCs seen in mice. Additionally, the topological organization of septal MC axons differs, particularly in relative axonal density along the septotemporal axis. These findings provide insights into the anatomical evolution of the DG circuit in mammals, shedding light on potential functional distinctions. The study enhances our understanding of neural circuitry, offering a platform for further exploration into the intricate relationship between structure and function in the mammalian brain

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Connectivity and synaptic features of hilar mossy cells and their effects on granule cell activity along the hippocampal longitudinal axis

Abstract: support-information-section).

Cited by 3 publications

References 61 publications

Beyond the trisynaptic circuit: hilar mossy cells orchestrate the longitudinal control of dentate granule cell activity

Beyond the trisynaptic circuit: hilar mossy cells orchestrate the longitudinal control of dentate granule cell activity

Similar Presynaptic Action Potential-Calcium Influx Coupling in Two Types of Large Mossy Fiber Terminals Innervating CA3 Pyramidal Cells and Hilar Mossy Cells

Comparative Anatomy of the Dentate Mossy Cells in Nonhuman Primates: Their Spatial Distributions and Axonal Projections Compared With Mouse Mossy Cells

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